Literature DB >> 28646533

Palladium-Catalyzed Fluoroarylation of gem-Difluoroalkenes.

Hai-Jun Tang1, Ling-Zhi Lin1, Chao Feng1, Teck-Peng Loh2.   

Abstract

A Pd-catalyzed fluoroarylation of gem-difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α-CF3 -benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem-difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non-symmetric α,α-disubstituted trifluoroethane derivatives.
© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  arylation; cross-coupling; fluorination; gem-difluoroalkenes; palladium

Year:  2017        PMID： 28646533     DOI： 10.1002/anie.201705321

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  7 in total

1.  Recent Advances in Transition Metal-Catalyzed Functionalization of gem-Difluoroalkenes.

Authors:  Suvajit Koley; Ryan A Altman
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Authors:  Steven J Malcolmson; Kangnan Li; Xinxin Shao
Journal:  Synlett       Date:  2019-03-26       Impact factor: 2.454

3.  Cu(II)-Catalyzed Unsymmetrical Dioxidation of gem-Difluoroalkenes to Generate α,α-Difluorinated-α-phenoxyketones.

Authors:  Suvajit Koley; Kaylee T Cayton; Gisela A González-Montiel; M Ramu Yadav; Douglas L Orsi; Andrew J Intelli; Paul Ha-Yeon Cheong; Ryan A Altman
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4.  Cobalt-Catalyzed Selective Unsymmetrical Dioxidation of gem-Difluoroalkenes.

Authors:  Douglas L Orsi; Justin T Douglas; Jacob P Sorrentino; Ryan A Altman
Journal:  J Org Chem       Date:  2020-08-05       Impact factor: 4.354

5.  Synthesis of bioactive fluoropyrrolidines via copper(i)-catalysed asymmetric 1,3-dipolar cycloaddition of azomethine ylides.

Authors:  Xiao Xu; Longzhu Bao; Lu Ran; Zhenyan Yang; Dingce Yan; Chun-Jiang Wang; Huailong Teng
Journal:  Chem Sci       Date:  2021-12-07       Impact factor: 9.825

6.  A novel type of donor-acceptor cyclopropane with fluorine as the donor: (3 + 2)-cycloadditions with carbonyls.

Authors:  Haidong Liu; Lifang Tian; Hui Wang; Zhi-Qiang Li; Chi Zhang; Fei Xue; Chao Feng
Journal:  Chem Sci       Date:  2022-02-15       Impact factor: 9.825

7.  Arylation of gem-difluoroalkenes using a Pd/Cu Co-catalytic system that avoids β-fluoride elimination.

Authors:  Kedong Yuan; Taisiia Feoktistova; Paul Ha-Yeon Cheong; Ryan A Altman
Journal:  Chem Sci       Date:  2020-11-25       Impact factor: 9.825
  7 in total

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