| Literature DB >> 28643857 |
Min Soh1,2, Dong-Wan Kang3,4, Han-Gil Jeong3,4, Dokyoon Kim1,2, Do Yeon Kim3,4, Wookjin Yang3,4, Changyeong Song1,2, Seungmin Baik1,2, In-Young Choi3,4, Seul-Ki Ki3,4, Hyek Jin Kwon1,2, Taeho Kim1,2, Chi Kyung Kim3,5, Seung-Hoon Lee3,4, Taeghwan Hyeon1,2.
Abstract
The two oxidation states of ceria nanoparticles, Ce3+ and Ce4+ , play a pivotal role in scavenging reactive oxygen species (ROS). In particular, Ce3+ is largely responsible for removing O2- and . OH that are associated with inflammatory response and cell death. The synthesis is reported of 2 nm ceria-zirconia nanoparticles (CZ NPs) that possess a higher Ce3+ /Ce4+ ratio and faster conversion from Ce4+ to Ce3+ than those exhibited by ceria nanoparticles. The obtained Ce0.7 Zr0.3 O2 (7CZ) NPs greatly improve ROS scavenging performance, thus regulating inflammatory cells in a very low dose. Moreover, 7CZ NPs are demonstrated to be effective in reducing mortality and systemic inflammation in two representative sepsis models. These findings suggest that 7CZ NPs have the potential as a therapeutic nanomedicine for treating ROS-related inflammatory diseases.Entities:
Keywords: ceria-zirconia nanoparticles; inflammation; reactive oxygen species; sepsis; therapeutic nanomedicine
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Year: 2017 PMID： 28643857 DOI： 10.1002/anie.201704904
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336