Sree Kanthaswamy1,2,3,4, Jillian Ng4, Robert F Oldt1,3, Kathrine Phillippi-Falkenstein5, H Michael Kubisch5. 1. School of Mathematics and Natural Sciences, Arizona State University (ASU) at the West Campus, Glendale, AZ, USA. 2. Julie Ann Wrigley Global Institute of Sustainability, Arizona State University, Tempe, AZ, USA. 3. Evolutionary Biology PhD program, School of Life Sciences, Arizona State University, Tempe, AZ, USA. 4. California National Primate Research Center, University of California, Davis, CA, USA. 5. Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA, USA.
Abstract
BACKGROUND: The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center (TNPRC) has one of the largest rhesus macaque breeding colonies in the United States. METHODS: SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry. RESULTS: Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation. CONCLUSIONS: The TNPRC colony managers have successfully minimized loss in genetic variation across generations. Although founder effects and bottlenecks among the Indian animals have been successfully curtailed, the Chinese subpopulation still show some influences from these events.
BACKGROUND: The rhesus macaque is an important biomedical model organism, and the Tulane National Primate Research Center (TNPRC) has one of the largest rhesus macaque breeding colonies in the United States. METHODS: SNP profiles from 3266 rhesus macaques were used to examine the TNPRC colony genetic composition over time and across conventional or SPF animals of Chinese and Indian ancestry. RESULTS: Chinese origin animals were the least genetically diverse and the most inbred; however, since their derivation from their conventional forebearers, neither the Chinese nor the Indian SPF animals exhibit any significant loss of genetic diversity or differentiation. CONCLUSIONS: The TNPRC colony managers have successfully minimized loss in genetic variation across generations. Although founder effects and bottlenecks among the Indian animals have been successfully curtailed, the Chinese subpopulation still show some influences from these events.
Authors: S Kanthaswamy; J P Capitanio; C J Dubay; B Ferguson; T Folks; J C Ha; C E Hotchkiss; Z P Johnson; M G Katze; L S Kean; H Michael Kubisch; S Lank; L A Lyons; G M Miller; J Nylander; D H O'Connor; R E Palermo; D G Smith; E J Vallender; R W Wiseman; J Rogers Journal: J Med Primatol Date: 2009-10 Impact factor: 0.667
Authors: Sree Kanthaswamy; Alex Kou; Jessica Satkoski; Maria Cecilia T Penedo; Thea Ward; Jillian Ng; Leanne Gill; Nicholas W Lerche; Bethany J-A Erickson; David Glenn Smith Journal: Am J Primatol Date: 2010-06 Impact factor: 2.371
Authors: Bapi Pahar; Andrew A Lackner; Michael Piatak; Jeffrey D Lifson; Xiaolei Wang; Arpita Das; Binhua Ling; David C Montefiori; Ronald S Veazey Journal: Virology Date: 2009-03-18 Impact factor: 3.616
Authors: Cheng Xue; Muthuswamy Raveendran; R Alan Harris; Gloria L Fawcett; Xiaoming Liu; Simon White; Mahmoud Dahdouli; David Rio Deiros; Jennifer E Below; William Salerno; Laura Cox; Guoping Fan; Betsy Ferguson; Julie Horvath; Zach Johnson; Sree Kanthaswamy; H Michael Kubisch; Dahai Liu; Michael Platt; David G Smith; Binghua Sun; Eric J Vallender; Feng Wang; Roger W Wiseman; Rui Chen; Donna M Muzny; Richard A Gibbs; Fuli Yu; Jeffrey Rogers Journal: Genome Res Date: 2016-10-17 Impact factor: 9.043
Authors: Betsy Ferguson; Summer L Street; Hollis Wright; Carlo Pearson; Yibing Jia; Shaun L Thompson; Patrick Allibone; Christopher J Dubay; Eliot Spindel; Robert B Norgren Journal: BMC Genomics Date: 2007-02-07 Impact factor: 3.969