BACKGROUND: Acute infections with Mycoplasma pneumoniae (Mp) have been associated with worsening asthma in children. Mp can be present in the respiratory tract for extended periods; it is unknown whether the long-term persistence of Mp in the respiratory tract affects long-term asthma control. OBJECTIVE: To determine the effect of Mp on asthma control. METHODS: We enrolled 31 pediatric subjects 3 to 10 years of age with persistent asthma who completed up to 8 visits over a 24-month period. We detected Mp by antigen capture and polymerase chain reaction. Primary outcome measurements included symptom scores, quality of life, medication scores, oral corticosteroid use, health care usage, school absences, and exhaled breath condensate pH. RESULTS: Low levels of Mp community-acquired respiratory distress syndrome toxin were detected in 20 subjects (64.5%) at enrollment. Subjects with Mp positivity at a given visit had a .579 probability of remaining Mp positive at the subsequent visit, whereas those with Mp negativity had a .348 probability of becoming Mp positive at the following visit. The incidence of Mp overall was higher in the spring and summer months. Overall, we found no significant relation between the detection of Mp and worse outcome measurements at the same visit or at subsequent visits. CONCLUSION: The long-term persistence of Mp in the respiratory tract is common in children with asthma. However, the detection of Mp was not associated significantly with worse asthma symptoms, quality of life, health care usage, school absences, or exhaled breath condensate pH in this pediatric asthma cohort.
BACKGROUND:Acute infections with Mycoplasma pneumoniae (Mp) have been associated with worsening asthma in children. Mp can be present in the respiratory tract for extended periods; it is unknown whether the long-term persistence of Mp in the respiratory tract affects long-term asthma control. OBJECTIVE: To determine the effect of Mp on asthma control. METHODS: We enrolled 31 pediatric subjects 3 to 10 years of age with persistent asthma who completed up to 8 visits over a 24-month period. We detected Mp by antigen capture and polymerase chain reaction. Primary outcome measurements included symptom scores, quality of life, medication scores, oral corticosteroid use, health care usage, school absences, and exhaled breath condensate pH. RESULTS: Low levels of Mp community-acquired respiratory distress syndrome toxin were detected in 20 subjects (64.5%) at enrollment. Subjects with Mp positivity at a given visit had a .579 probability of remaining Mp positive at the subsequent visit, whereas those with Mp negativity had a .348 probability of becoming Mp positive at the following visit. The incidence of Mp overall was higher in the spring and summer months. Overall, we found no significant relation between the detection of Mp and worse outcome measurements at the same visit or at subsequent visits. CONCLUSION: The long-term persistence of Mp in the respiratory tract is common in children with asthma. However, the detection of Mp was not associated significantly with worse asthma symptoms, quality of life, health care usage, school absences, or exhaled breath condensate pH in this pediatric asthma cohort.
Authors: R Evans; P J Gergen; H Mitchell; M Kattan; C Kercsmar; E Crain; J Anderson; P Eggleston; F J Malveaux; H J Wedner Journal: J Pediatr Date: 1999-09 Impact factor: 4.406
Authors: Seema Jain; Derek J Williams; Sandra R Arnold; Krow Ampofo; Anna M Bramley; Carrie Reed; Chris Stockmann; Evan J Anderson; Carlos G Grijalva; Wesley H Self; Yuwei Zhu; Anami Patel; Weston Hymas; James D Chappell; Robert A Kaufman; J Herman Kan; David Dansie; Noel Lenny; David R Hillyard; Lia M Haynes; Min Levine; Stephen Lindstrom; Jonas M Winchell; Jacqueline M Katz; Dean Erdman; Eileen Schneider; Lauri A Hicks; Richard G Wunderink; Kathryn M Edwards; Andrew T Pavia; Jonathan A McCullers; Lyn Finelli Journal: N Engl J Med Date: 2015-02-26 Impact factor: 91.245
Authors: J W Dorigo-Zetsma; B Wilbrink; H van der Nat; A I Bartelds; M L Heijnen; J Dankert Journal: J Infect Dis Date: 2000-12-27 Impact factor: 5.226
Authors: Andrew H Liu; Denise C Babineau; Rebecca Z Krouse; Edward M Zoratti; Jacqueline A Pongracic; George T O'Connor; Robert A Wood; Gurjit K Khurana Hershey; Carolyn M Kercsmar; Rebecca S Gruchalla; Meyer Kattan; Stephen J Teach; Melanie Makhija; Dinesh Pillai; Carin I Lamm; James E Gern; Steven M Sigelman; Peter J Gergen; Alkis Togias; Cynthia M Visness; William W Busse Journal: J Allergy Clin Immunol Date: 2016-10 Impact factor: 10.793
Authors: T R Kannan; Oxana Musatovova; Sowmya Balasubramanian; Marianna Cagle; Jarrat L Jordan; Thomas M Krunkosky; Alan Davis; Robert D Hardy; Joel B Baseman Journal: Mol Microbiol Date: 2010-02-28 Impact factor: 3.501
Authors: Jill S Halterman; Maria Fagnano; Paul J Tremblay; Susan G Fisher; Hongyue Wang; Cynthia Rand; Peter Szilagyi; Arlene Butz Journal: JAMA Pediatr Date: 2014-10-06 Impact factor: 16.193
Authors: Hongbo Wu; Shu Li; Linlin Wang; Jun Liang; Lei Yan; Jianjiang Dong Journal: Evid Based Complement Alternat Med Date: 2022-04-21 Impact factor: 2.650