Nian-Sheng Tzeng1,2, Chi-Hsiang Chung3,4,5, Fu-Huang Lin3, Chin-Bin Yeh1, San-Yuan Huang1, Ru-Band Lu1,6, Hsin-An Chang1,2, Yu-Chen Kao1,7, Hui-Wen Yeh1,8,9, Wei-Shan Chiang1,10, Yu-Ching Chou3, Chang-Huei Tsao4,11, Yung-Fu Wu4, Wu-Chien Chien3,4. 1. 1 Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China. 2. 2 Student Counseling Center, National Defense Medical Center, Taipei, Taiwan, Republic of China. 3. 3 School of Public Health, National Defense Medical Center, Taipei, Taiwan, Republic of China. 4. 4 Department of Medical Research, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China. 5. 5 Taiwanese Injury Prevention and Safety Promotion Association, Taipei, Taiwan, Republic of China. 6. 6 Department of Psychiatry, College of Medicine & Hospital, National Cheng Kung University, Tainan, Taiwan, Republic of China. 7. 7 Department of Psychiatry, Tri-Service General Hospital, Song-Shan Branch, National Defense Medical Center, Taipei, Taiwan, Republic of China. 8. 8 Institute of Bioinformatics and System Biology, National Chiao Tung University, Hsin-Chu, Taiwan, Republic of China. 9. 9 Department of Nursing, Kang-Ning University (Taipei Campus), Taipei, Taiwan, Republic of China. 10. 10 Department and Institute of Mathematics, Tamkang University, New Taipei City, Taiwan, Republic of China. 11. 11 Department and Institute of Microbiology and Immunology, School of Medicine, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Abstract
OBJECTIVE: This study aimed to investigate the association between adults with ADHD and the risk of developing dementia. METHOD: Utilizing National Health Insurance Research Database of Taiwan, ADHD patients were identified and compared with age- and gender-matched controls (1:3). RESULTS: Of the study participants, 37 (5.48%) developed dementia compared with 81 (4.0%) in the control group. Cox proportional hazards regression analysis revealed that the study participants were more likely to develop dementia. The crude hazard ratio (HR) is 3.418 (95% confidence interval [CI] = [2.289, 5.106], p < .001), and adjusted HR is 4.008 (95% CI = [2.526, 6.361], p < .001) in risk of developing dementia after adjusted for age, gender, comorbidities, geographical area of residence, urbanization level of residence, and monthly income. CONCLUSION: Adults with ADHD have a 3.4-fold risk of developing dementia, and other large or national data sets should be explored to support the current findings.
OBJECTIVE: This study aimed to investigate the association between adults with ADHD and the risk of developing dementia. METHOD: Utilizing National Health Insurance Research Database of Taiwan, ADHDpatients were identified and compared with age- and gender-matched controls (1:3). RESULTS: Of the study participants, 37 (5.48%) developed dementia compared with 81 (4.0%) in the control group. Cox proportional hazards regression analysis revealed that the study participants were more likely to develop dementia. The crude hazard ratio (HR) is 3.418 (95% confidence interval [CI] = [2.289, 5.106], p < .001), and adjusted HR is 4.008 (95% CI = [2.526, 6.361], p < .001) in risk of developing dementia after adjusted for age, gender, comorbidities, geographical area of residence, urbanization level of residence, and monthly income. CONCLUSION: Adults with ADHD have a 3.4-fold risk of developing dementia, and other large or national data sets should be explored to support the current findings.
Entities:
Keywords:
ADHD adults; Longitudinal Health Insurance Database; National Health Insurance Research Database; adults; cohort study; dementia
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