Tope Olufade1, Amanda M Kong2, Nicole Princic3, Paul Juneau4, Rucha Kulkarni5, Kui Zhang6, Catherine Datto7. 1. Director, Health Economics & Outcomes Research, AstraZeneca, Wilmington, DE. 2. Research Leader, Truven Health Analytics, an IBM Company, Bethesda, MD. 3. Manager Research Analyst, Truven Health Analytics, an IBM Company, Bethesda, MD. 4. Senior Statistician, Truven Health Analytics, an IBM Company, Bethesda, MD. 5. Research Analyst at the time of this study, Truven Health Analytics, an IBM Company, Bethesda, MD. 6. Senior Programmer/Analyst, Truven Health Analytics, an IBM Company, Bethesda, MD. 7. US Medical Lead, AstraZeneca.
Abstract
BACKGROUND: Constipation is a common adverse effect of opioid use and has been associated with increased healthcare utilization and costs among patients receiving opioids for pain management. OBJECTIVE: To compare the healthcare utilization and costs of Medicaid patients with chronic noncancer pain with and without constipation who were receiving opioids. METHODS: This retrospective, claims-based study was conducted using data from the Truven Health MarketScan Medicaid Multi-State database. Patients with no evidence of cancer who initiated opioid therapy between January 1, 2009, and June 30, 2013, were eligible for the study. Patients had to have continuous enrollment in the database in the 6 months before and 12 months after opioid initiation, with no evidence of substance abuse or functional or inflammatory bowel disease. Medical and pharmacy claims during the 12 months after opioid initiation were evaluated for a diagnosis of constipation or for prescription or over-the-counter medications indicative of constipation. All-cause healthcare utilization and costs were measured over the same period and were compared between propensity score-matched cohorts of patients with evidence of constipation and patients without constipation. RESULTS: Of the 25,744 patients meeting the study inclusion criteria, 2716 (10.5%) had evidence of constipation. After 1:1 propensity score matching, the 2 cohorts had similar demographic and clinical characteristics (ie, mean age, 47 years; 26%-27% male). During the 12-month follow-up period, healthcare utilization was more frequent among patients with constipation, including inpatient admissions and emergency department visits, than in the matched patients without constipation. The total all-cause mean healthcare costs were substantially higher among the patients with constipation ($28,234; 95% confidence interval [CI], $24,307-$32,160) than in the patients without constipation ($13,709; 95% CI, $12,618-$14,801), with a median cost difference of $4166 per patient (P <.001). CONCLUSION: Among Medicaid enrollees who receive opioids for chronic noncancer pain, constipation is associated with increased all-cause healthcare utilization and costs.
BACKGROUND:Constipation is a common adverse effect of opioid use and has been associated with increased healthcare utilization and costs among patients receiving opioids for pain management. OBJECTIVE: To compare the healthcare utilization and costs of Medicaid patients with chronic noncancer pain with and without constipation who were receiving opioids. METHODS: This retrospective, claims-based study was conducted using data from the Truven Health MarketScan Medicaid Multi-State database. Patients with no evidence of cancer who initiated opioid therapy between January 1, 2009, and June 30, 2013, were eligible for the study. Patients had to have continuous enrollment in the database in the 6 months before and 12 months after opioid initiation, with no evidence of substance abuse or functional or inflammatory bowel disease. Medical and pharmacy claims during the 12 months after opioid initiation were evaluated for a diagnosis of constipation or for prescription or over-the-counter medications indicative of constipation. All-cause healthcare utilization and costs were measured over the same period and were compared between propensity score-matched cohorts of patients with evidence of constipation and patients without constipation. RESULTS: Of the 25,744 patients meeting the study inclusion criteria, 2716 (10.5%) had evidence of constipation. After 1:1 propensity score matching, the 2 cohorts had similar demographic and clinical characteristics (ie, mean age, 47 years; 26%-27% male). During the 12-month follow-up period, healthcare utilization was more frequent among patients with constipation, including inpatient admissions and emergency department visits, than in the matched patients without constipation. The total all-cause mean healthcare costs were substantially higher among the patients with constipation ($28,234; 95% confidence interval [CI], $24,307-$32,160) than in the patients without constipation ($13,709; 95% CI, $12,618-$14,801), with a median cost difference of $4166 per patient (P <.001). CONCLUSION: Among Medicaid enrollees who receive opioids for chronic noncancer pain, constipation is associated with increased all-cause healthcare utilization and costs.
Authors: Tope Olufade; Amanda M Kong; Nicole Princic; Paul Juneau; Rucha Kulkarni; Kui Zhang; Catherine Datto Journal: Am Health Drug Benefits Date: 2017-04
Authors: Ancilla W Fernandes; David M Kern; Catherine Datto; Yen-Wen Chen; Charles McLeskey; Ozgur Tunceli Journal: Am Health Drug Benefits Date: 2016-05
Authors: Tope Olufade; Amanda M Kong; Nicole Princic; Paul Juneau; Rucha Kulkarni; Kui Zhang; Catherine Datto Journal: Am Health Drug Benefits Date: 2017-04
Authors: W Frank Peacock; Neal Slatkin; Patrick Gagnon-Sanschagrin; Jessica Maitland; Annie Guérin; George Joseph Journal: Adv Ther Date: 2022-03-17 Impact factor: 3.845