| Literature DB >> 28625064 |
Beatriz Lozano-Torres1,2,3,4, Irene Galiana1,2,3,4, Miguel Rovira5, Eva Garrido1,2,3,4, Selim Chaib5, Andrea Bernardos1,2,3,4, Daniel Muñoz-Espín5,6, Manuel Serrano5, Ramón Martínez-Máñez1,2,3,4, Félix Sancenón1,2,3,4.
Abstract
A naphthalimide-based two-photon probe (AHGa) for the detection of cell senescence is designed. The probe contains a naphthalimide core, an l-histidine methyl ester linker, and an acetylated galactose bonded to one of the aromatic nitrogen atoms of the l-histidine through a hydrolyzable N-glycosidic bond. Probe AHGa is transformed into AH in senescent cells resulting in an enhanced fluorescent emission intensity. In vivo detection of senescence is validated in mice bearing tumor xenografts treated with senescence-inducing chemotherapy.Entities:
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Year: 2017 PMID： 28625064 DOI： 10.1021/jacs.7b04985
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419