Christof Karmonik1, Jeff R Anderson2, Saba Elias2, Richard Klucznik3, Orlando Diaz3, Yi Jonathan Zhang4, Robert G Grossman4, Gavin W Britz4. 1. Cerebrovascular Center, Department of Neurosurgery, Houston Methodist Hospital, Houston, Texas, USA; MRI Core, Houston Methodist Research Institute, Houston, Texas, USA. Electronic address: ckarmonik@houstonmethodist.org. 2. MRI Core, Houston Methodist Research Institute, Houston, Texas, USA. 3. Cerebrovascular Center, Department of Neurosurgery, Houston Methodist Hospital, Houston, Texas, USA; Department of Radiology, Houston Methodist Hospital, Houston, Texas, USA. 4. Cerebrovascular Center, Department of Neurosurgery, Houston Methodist Hospital, Houston, Texas, USA.
Abstract
OBJECTIVE: Hemodynamics in cerebral aneurysms are currently investigated toward clinical efficacy using nonstandardized computational simulation techniques. At the same time, flow patterns and velocities are accessible by 4-dimensional phase contrast magnetic resonance imaging (4D pcMRI). Complexity of protocol design and imaging duration has limited the use of this technique in clinical imaging. A new approach is presented to overcome these limitations. METHODS: Three-dimensional (3D) replicas of 2 cerebral aneurysms were fabricated by fused deposition prototyping (3D printing) and imaged using 4D pcMRI while connected to a magnetic resonance imaging-compatible continuous flow loop. Acquisition parameters were optimized with imaging times not to exceed 10 minutes. Six patients harboring cerebral aneurysms with sizes ranging from 4.7 to 13.8 mm were imaged with the optimized 4D pcMRI protocol. After treatment with the pipeline embolization device (PED), 4D pcMRI examinations were repeated in 3 patients. RESULTS: In all cases, major flow patterns were visualized well; smaller aneurysms posed a challenge because of limited spatial resolution, whereas larger aneurysms contained regions of low velocity resulting in limited contrast in the flow-sensitive images. After PED placement, ordered aneurysmal flow was disrupted and intra-aneurysmal velocity was reduced on average by 24.5% (range, 12.9-31.5%). Exploratory statistical analysis yielded a positive significant correlation (P < 0.01) between changes in inflow velocity and posttreatment intra-aneurysmal flow velocity. CONCLUSIONS: 4D pcMRI flow imaging in cerebral aneurysms within a time frame suitable for clinical imaging applications is feasible with optimized acquisition parameters, thereby enabling quantification of intra-aneurysmal flow changes after flow diverter device treatment.
OBJECTIVE: Hemodynamics in cerebral aneurysms are currently investigated toward clinical efficacy using nonstandardized computational simulation techniques. At the same time, flow patterns and velocities are accessible by 4-dimensional phase contrast magnetic resonance imaging (4D pcMRI). Complexity of protocol design and imaging duration has limited the use of this technique in clinical imaging. A new approach is presented to overcome these limitations. METHODS: Three-dimensional (3D) replicas of 2 cerebral aneurysms were fabricated by fused deposition prototyping (3D printing) and imaged using 4D pcMRI while connected to a magnetic resonance imaging-compatible continuous flow loop. Acquisition parameters were optimized with imaging times not to exceed 10 minutes. Six patients harboring cerebral aneurysms with sizes ranging from 4.7 to 13.8 mm were imaged with the optimized 4D pcMRI protocol. After treatment with the pipeline embolization device (PED), 4D pcMRI examinations were repeated in 3 patients. RESULTS: In all cases, major flow patterns were visualized well; smaller aneurysms posed a challenge because of limited spatial resolution, whereas larger aneurysms contained regions of low velocity resulting in limited contrast in the flow-sensitive images. After PED placement, ordered aneurysmal flow was disrupted and intra-aneurysmal velocity was reduced on average by 24.5% (range, 12.9-31.5%). Exploratory statistical analysis yielded a positive significant correlation (P < 0.01) between changes in inflow velocity and posttreatment intra-aneurysmal flow velocity. CONCLUSIONS: 4D pcMRI flow imaging in cerebral aneurysms within a time frame suitable for clinical imaging applications is feasible with optimized acquisition parameters, thereby enabling quantification of intra-aneurysmal flow changes after flow diverter device treatment.
Authors: T Su; P Reymond; O Brina; P Bouillot; P Machi; B M A Delattre; L Jin; K O Lövblad; M I Vargas Journal: AJNR Am J Neuroradiol Date: 2020-02-13 Impact factor: 3.825
Authors: O Brina; P Bouillot; P Reymond; A S Luthman; C Santarosa; M Fahrat; K O Lovblad; P Machi; B M A Delattre; V M Pereira; M I Vargas Journal: AJNR Am J Neuroradiol Date: 2019-11-14 Impact factor: 3.825