Francis Char DeCroos1, David Reed2, Murtaza K Adam2, David Salz2, Omesh P Gupta2, Allen C Ho2, Carl D Regillo3. 1. Retina Service, Wills Eye Hospital/Mid Atlantic Retina, Philadelphia, Pennslyvania; Southeastern Retina Associates, Chattanooga, Tennessee. 2. Retina Service, Wills Eye Hospital/Mid Atlantic Retina, Philadelphia, Pennslyvania. 3. Retina Service, Wills Eye Hospital/Mid Atlantic Retina, Philadelphia, Pennslyvania. Electronic address: cregillo@midatanticretina.com.
Abstract
PURPOSE: To determine the efficacy and durability of aflibercept used in a treat-and-extend (TAE) regimen for neovascular age-related macular degeneration (NVAMD). DESIGN: Multicenter, prospective, open label, noncomparative, interventional study. METHODS: Forty eyes of 40 patients with treatment-naïve NVAMD were managed with a TAE regimen of intravitreal aflibercept. The main endpoints were the change in mean and median best-corrected visual acuity from baseline at years 1 and 2. Other endpoints included mean number of annual injections and treatment intervals. RESULTS: Thirty-five (87.5%) and 31 patients (77.5%) completed year 1 and year 2, respectively. The mean letter gain was 7.2 (P < .001) and 2.4 (P = .269) letters at 1 and 2 years, respectively, from a mean baseline of 58.9 letters (20/63 Snellen equivalent). The median visual gain was 11.5 and 7.5 letters at 1 and 2 years, respectively, from a median baseline of 59.0 letters (20/63 Snellen equivalent). The mean number of injections was 8.0 and 6.5 during the first and second year, respectively. Twelve-week or longer treatment intervals were used in 35% and 38% of patients during the first- and second-year time points, respectively. CONCLUSION: Intravitreal aflibercept TAE therapy led to significant visual improvement in eyes with NVAMD at 1 year, with some loss in the visual gains at the end of year 2 that was not related to loss of exudative control. TAE therapy with aflibercept is a rational strategy to reduce treatments and clinic evaluations over 2 years with satisfactory outcomes.
PURPOSE: To determine the efficacy and durability of aflibercept used in a treat-and-extend (TAE) regimen for neovascular age-related macular degeneration (NVAMD). DESIGN: Multicenter, prospective, open label, noncomparative, interventional study. METHODS: Forty eyes of 40 patients with treatment-naïve NVAMD were managed with a TAE regimen of intravitreal aflibercept. The main endpoints were the change in mean and median best-corrected visual acuity from baseline at years 1 and 2. Other endpoints included mean number of annual injections and treatment intervals. RESULTS: Thirty-five (87.5%) and 31 patients (77.5%) completed year 1 and year 2, respectively. The mean letter gain was 7.2 (P < .001) and 2.4 (P = .269) letters at 1 and 2 years, respectively, from a mean baseline of 58.9 letters (20/63 Snellen equivalent). The median visual gain was 11.5 and 7.5 letters at 1 and 2 years, respectively, from a median baseline of 59.0 letters (20/63 Snellen equivalent). The mean number of injections was 8.0 and 6.5 during the first and second year, respectively. Twelve-week or longer treatment intervals were used in 35% and 38% of patients during the first- and second-year time points, respectively. CONCLUSION: Intravitreal aflibercept TAE therapy led to significant visual improvement in eyes with NVAMD at 1 year, with some loss in the visual gains at the end of year 2 that was not related to loss of exudative control. TAE therapy with aflibercept is a rational strategy to reduce treatments and clinic evaluations over 2 years with satisfactory outcomes.
Authors: Peter K Kaiser; Charles C Wykoff; Rishi P Singh; Arshad M Khanani; Diana V Do; Hersh Patel; Nikhil Patel Journal: Retina Date: 2021-08-01 Impact factor: 3.975
Authors: Praveen J Patel; Helen Devonport; Sobha Sivaprasad; Adam H Ross; Gavin Walters; Richard P Gale; Andrew J Lotery; Sajjad Mahmood; James S Talks; Jackie Napier Journal: Clin Ophthalmol Date: 2017-11-06
Authors: Praveen J Patel; Hari Jayaram; Maria Eleftheriadou; Clara Vazquez-Alfageme; Niaz Islam; Gary S Rubin; Bishwanath Pal; Peter K Addison; Robin Hamilton; Simona Degli Esposti Journal: Ophthalmol Ther Date: 2020-06-18
Authors: A García-Layana; J García-Arumí; M S Figueroa; L Arias Barquet; J M Ruíz-Moreno; L Monclús-Arbona Journal: J Ophthalmol Date: 2019-09-30 Impact factor: 1.909