| Literature DB >> 28623654 |
Karen W Phinney1, Johanna E Camara1, Susan S-C Tai1, Lane C Sander1, Stephen A Wise1, Linde A C De Grande2, Linda M Thienpont2, Antonio M Possolo3, Blaza Toman3, Christopher T Sempos4, Joseph M Betz4, Paul M Coates4.
Abstract
Assay variability has been cited as an obstacle to establishing optimal vitamin D exposure. As part of the Vitamin D Standardization Program (VDSP) effort to standardize the measurement of total 25-hydroxyvitamin D [25(OH)D], the value assignment of total 25(OH)D in 50 single-donor serum samples was performed using two isotope-dilution LC with tandem MS methods. Both methods are recognized as reference measurement procedures (RMPs) by the Joint Committee for Traceability in Laboratory Medicine. These samples and their assigned values serve as the foundation for several aspects of the VDSP. To our knowledge, this is the first time that two RMPs have been used to assign 25(OH)D values to such a large number of serum samples.Entities:
Mesh：
Substances：
Year: 2017 PMID： 28623654 PMCID： PMC5601309 DOI： 10.5740/jaoacint.17-0204
Source DB: PubMed Journal: J AOAC Int ISSN： 1060-3271 Impact factor: 1.913