Literature DB >> 28620742

Multireflection propagation of conformational kinks in a two-component model of DNA as the transfer mode of the transcriptional replication fork.

E S Shikhovtseva1, V N Nazarov2.   

Abstract

The propagation, or movement, of a conformational kink along a linear structure can occur in capture, transfer, or multireflection modes. Here we use a model for two-component bistable polymer molecules with energetically non-equivalent stable states to model the propagation of the DNA transcription bubble via movement of a non-linear longitudinal stretching region along the DNA chain. We show that under certain conditions the longitudinal excitation can act as a reflector for a conformational kink and, furthermore, that conformational switching may propagate in a multireflection mode alongside conformational kink transition and conformational kink trapping.

Entities:  

Keywords:  DNA; Kink multireflection; Longitudinal stretching; Perturbed sine–Gordon equation; Replication bubble

Mesh:

Substances:

Year:  2017        PMID: 28620742     DOI: 10.1007/s00249-017-1230-x

Source DB:  PubMed          Journal:  Eur Biophys J        ISSN: 0175-7571            Impact factor:   1.733


  6 in total

1.  Anharmonic longitudinal motion of bases and dynamics of nonlinear excitation in DNA.

Authors:  Angelo Di Garbo
Journal:  Biophys Chem       Date:  2015-09-28       Impact factor: 2.352

2.  Two-dimensional discrete model for DNA dynamics: Longitudinal wave propagation and denaturation.

Authors: 
Journal:  Phys Rev A       Date:  1990-12-15       Impact factor: 3.140

3.  Longitudinal displacements of base pairs in DNA and effects on the dynamics of nonlinear excitations.

Authors:  Angelo Di Garbo
Journal:  Math Biosci       Date:  2013-04-06       Impact factor: 2.144

4.  Non-linear longitudinal compression effect on dynamics of the transcription bubble in DNA.

Authors:  E S Shikhovtseva; V N Nazarov
Journal:  Biophys Chem       Date:  2016-05-16       Impact factor: 2.352

5.  Simulation of interactions between nucleic acid bases by refined atom-atom potential functions.

Authors:  V I Poltev; N V Shulyupina
Journal:  J Biomol Struct Dyn       Date:  1986-02

6.  Nature of the open state in long polynucleotide double helices: possibility of soliton excitations.

Authors:  S W Englander; N R Kallenbach; A J Heeger; J A Krumhansl; S Litwin
Journal:  Proc Natl Acad Sci U S A       Date:  1980-12       Impact factor: 11.205

  6 in total

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