| Literature DB >> 28620742 |
E S Shikhovtseva1, V N Nazarov2.
Abstract
The propagation, or movement, of a conformational kink along a linear structure can occur in capture, transfer, or multireflection modes. Here we use a model for two-component bistable polymer molecules with energetically non-equivalent stable states to model the propagation of the DNA transcription bubble via movement of a non-linear longitudinal stretching region along the DNA chain. We show that under certain conditions the longitudinal excitation can act as a reflector for a conformational kink and, furthermore, that conformational switching may propagate in a multireflection mode alongside conformational kink transition and conformational kink trapping.Entities:
Keywords: DNA; Kink multireflection; Longitudinal stretching; Perturbed sine–Gordon equation; Replication bubble
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Year: 2017 PMID: 28620742 DOI: 10.1007/s00249-017-1230-x
Source DB: PubMed Journal: Eur Biophys J ISSN: 0175-7571 Impact factor: 1.733