Mikkel Østergaard1,2, Iris Eshed3,4, Christian E Althoff3,4, Rene P Poggenborg3,4, Torsten Diekhoff3,4, Simon Krabbe3,4, Sabine Weckbach3,4, Robert G W Lambert3,4, Susanne J Pedersen3,4, Walter P Maksymowych3,4, Charles G Peterfy3,4, Jane Freeston3,4, Paul Bird3,4, Philip G Conaghan3,4, Kay-Geert A Hermann3,4. 1. From the Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Diagnostic Imaging, The Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Arthritis Imaging Research Group, Department of Radiology, Charité Medical School, Berlin; Radiology, Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Department of Radiology and Diagnostic Imaging, and Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; Spire Sciences Inc., Boca Raton, Florida, USA; St. James' University and Chapel Allerton Hospitals; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; University of New South Wales (NSW), Sydney, Australia. mo@dadlnet.dk. 2. M. Østergaard, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen; I. Eshed, MD, Associate Professor, Department of Diagnostic Imaging, The Sheba Medical Center, Sackler School of Medicine; C.E. Althoff, MD, Senior Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School; R.P. Poggenborg, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; T. Diekhoff, MD, Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School; S. Krabbe, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; S. Weckbach, MD, Professor of Radiology, Diagnostic and Interventional Radiology, University Hospital Heidelberg; R.G. Lambert, MB, BCh, FRCR, FRCPC, Professor, Department of Radiology and Diagnostic Imaging, University of Alberta; S.J. Pedersen, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; W.P. Maksymowych, MB, ChB, FRCP(C), Professor, FACP, Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta; C.G. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; J. Freeston, MD, PhD, Consultant Rheumatologist and Honorary Clinical Associate Professor, St. James' University and Chapel Allerton Hospitals; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, University of NSW; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; K.G. Hermann, MD, PhD, Senior Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School. mo@dadlnet.dk. 3. From the Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Rigshospitalet, Glostrup; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark; Department of Diagnostic Imaging, The Sheba Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Arthritis Imaging Research Group, Department of Radiology, Charité Medical School, Berlin; Radiology, Diagnostic and Interventional Radiology, University Hospital Heidelberg, Heidelberg, Germany; Department of Radiology and Diagnostic Imaging, and Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada; Spire Sciences Inc., Boca Raton, Florida, USA; St. James' University and Chapel Allerton Hospitals; Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds; UK National Institute for Health Research (NIHR) Leeds Musculoskeletal Biomedical Research Unit, Leeds, UK; University of New South Wales (NSW), Sydney, Australia. 4. M. Østergaard, MD, PhD, DMSc, Professor, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet, and Department of Clinical Medicine, University of Copenhagen; I. Eshed, MD, Associate Professor, Department of Diagnostic Imaging, The Sheba Medical Center, Sackler School of Medicine; C.E. Althoff, MD, Senior Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School; R.P. Poggenborg, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; T. Diekhoff, MD, Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School; S. Krabbe, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; S. Weckbach, MD, Professor of Radiology, Diagnostic and Interventional Radiology, University Hospital Heidelberg; R.G. Lambert, MB, BCh, FRCR, FRCPC, Professor, Department of Radiology and Diagnostic Imaging, University of Alberta; S.J. Pedersen, MD, PhD, COPECARE, Center for Rheumatology and Spine Diseases, Rigshospitalet; W.P. Maksymowych, MB, ChB, FRCP(C), Professor, FACP, Division of Rheumatology, Faculty of Medicine and Dentistry, University of Alberta; C.G. Peterfy, MD, PhD, FRCP, Chief Executive Officer, Spire Sciences Inc.; J. Freeston, MD, PhD, Consultant Rheumatologist and Honorary Clinical Associate Professor, St. James' University and Chapel Allerton Hospitals; P. Bird, BMed (Hons), FRACP, PhD, Grad Dip MRI, Associate Professor, University of NSW; P.G. Conaghan, MB, BS, PhD, FRACP, FRCP, Professor of Musculoskeletal Medicine, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Leeds Musculoskeletal Biomedical Research Unit; K.G. Hermann, MD, PhD, Senior Consultant, Arthritis Imaging Research Group, Department of Radiology, Charité Medical School.
Abstract
OBJECTIVE: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. METHODS: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. RESULTS: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. CONCLUSION: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement.
OBJECTIVE: Whole-body magnetic resonance imaging (WB-MRI) is a relatively new technique that can enable assessment of the overall inflammatory status of people with arthritis, but standards for image acquisition, definitions of key pathologies, and a quantification system are required. Our aim was to perform a systematic literature review (SLR) and to develop consensus definitions of key pathologies, anatomical locations for assessment, a set of MRI sequences and imaging planes for the different body regions, and a preliminary scoring system for WB-MRI in inflammatory arthritis. METHODS: An SLR was initially performed, searching for WB-MRI studies in arthritis, osteoarthritis, spondyloarthritis, or enthesitis. These results were presented to a meeting of the MRI in Arthritis Working Group together with an MR image review. Following this, preliminary standards for WB-MRI in inflammatory arthritides were developed with further iteration at the Working Group meetings at the Outcome Measures in Rheumatology (OMERACT) 2016. RESULTS: The SLR identified 10 relevant original articles (7 cross-sectional and 3 longitudinal, mostly focusing on synovitis and/or enthesitis in spondyloarthritis, 4 with reproducibility data). The Working Group decided on inflammation in peripheral joints and entheses as primary focus areas, and then developed consensus MRI definitions for these pathologies, selected anatomical locations for assessment, agreed on a core set of MRI sequences and imaging planes for the different regions, and proposed a preliminary scoring system. It was decided to test and further develop the system by iterative multireader exercises. CONCLUSION: These first steps in developing an OMERACT WB-MRI scoring system for use in inflammatory arthritides offer a framework for further testing and refinement.
Entities:
Keywords:
ARTHRITIS; ENTHESITIS; MAGNETIC RESONANCE IMAGING; OMERACT; SYNOVITIS
Authors: Alessia Alunno; Francesco Carubbi; Simon Stones; Roberto Gerli; Roberto Giacomelli; Xenofon Baraliakos Journal: Front Med (Lausanne) Date: 2018-10-24
Authors: Ernest Choy; Xenofon Baraliakos; Frank Behrens; Salvatore D'Angelo; Kurt de Vlam; Bruce W Kirkham; Mikkel Østergaard; Georg A Schett; Michael Rissler; Kamel Chaouche-Teyara; Chiara Perella Journal: Arthritis Res Ther Date: 2019-01-22 Impact factor: 5.156
Authors: Xenofon Baraliakos; Philip G Conaghan; Maria-Antonietta D'Agostino; Walter Maksymowych; Esperanza Naredo; Mikkel Ostergaard; Georg Schett; Paul Emery Journal: Eur J Rheumatol Date: 2019-01