Hiroyuki Agatsuma1, Kazuo Yoshida2, Ichiro Yoshino3, Meinoshin Okumura4, Masahiko Higashiyama5, Kenji Suzuki6, Masanori Tsuchida7, Jitsuo Usuda8, Hiroshi Niwa9. 1. Department of Thoracic Surgery, Shinshu University School of Medicine, Matsumoto, Japan. 2. Department of Thoracic Surgery, Shinshu University School of Medicine, Matsumoto, Japan. Electronic address: kxy13@yahoo.co.jp. 3. Department of General Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan. 4. Department of General Thoracic Surgery, Osaka University, Graduate School of Medicine, Osaka, Japan. 5. Department of Thoracic Surgery, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka, Japan. 6. Division of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan. 7. Division of Thoracic and Cardiovascular Surgery, Niigata University Graduate School of Medical and Dental Science, Niigata, Japan. 8. Department of Thoracic Surgery, Nippon Medical School, Tokyo, Japan. 9. Division of Thoracic Surgery, Respiratory Disease Center, Seirei Mikatahara General Hospital, Hamamatsu, Japan.
Abstract
BACKGROUND: This study was designed to evaluate the feasibility of video-assisted thoracoscopic surgery (VATS) and to compare the oncologic outcomes of VATS with those of sternotomy in patients with thymoma. METHODS: The clinical outcomes of 2,835 patients with thymic epithelial tumors treated between 1991 and 2010 in 32 Japanese institutions were collected retrospectively. The study compared postoperative complications, positive surgical margins, location of recurrence, and survival in 140 of 142 VATS-treated patients (VATS group) matched with 140 of 1,294 sternotomy-treated patients (ST group) by using propensity scores. RESULTS: Postoperative complications were observed in 8 patients in the VATS group. The morbidity rate in the VATS group was not different from that of the ST group (p = 0.25). Positive surgical margins were noted in 4 patients (3 in the VATS group; 1 in the ST group). There was no statistically significant difference in the recurrence rate between groups (median follow-up period: 3.7 years in the VATS group; 5.2 years in the ST group). In total the most frequent site of recurrence was pleural dissemination. In the VATS group, the 5-year recurrence-free survival rate was 93.8%, and the 5-year overall survival rate was 97.9%. There was no difference in the recurrence-free survival and overall survival rates between the VATS group and the ST group (p = 0.91 and p = 0.74, respectively). CONCLUSIONS: VATS thymectomy was feasible and comparable to sternotomy for the treatment of patients with thymoma with regard to morbidity, incomplete resection rate, and prognosis. However, additional follow-up is required to evaluate long-term outcomes.
BACKGROUND: This study was designed to evaluate the feasibility of video-assisted thoracoscopic surgery (VATS) and to compare the oncologic outcomes of VATS with those of sternotomy in patients with thymoma. METHODS: The clinical outcomes of 2,835 patients with thymic epithelial tumors treated between 1991 and 2010 in 32 Japanese institutions were collected retrospectively. The study compared postoperative complications, positive surgical margins, location of recurrence, and survival in 140 of 142 VATS-treated patients (VATS group) matched with 140 of 1,294 sternotomy-treated patients (ST group) by using propensity scores. RESULTS: Postoperative complications were observed in 8 patients in the VATS group. The morbidity rate in the VATS group was not different from that of the ST group (p = 0.25). Positive surgical margins were noted in 4 patients (3 in the VATS group; 1 in the ST group). There was no statistically significant difference in the recurrence rate between groups (median follow-up period: 3.7 years in the VATS group; 5.2 years in the ST group). In total the most frequent site of recurrence was pleural dissemination. In the VATS group, the 5-year recurrence-free survival rate was 93.8%, and the 5-year overall survival rate was 97.9%. There was no difference in the recurrence-free survival and overall survival rates between the VATS group and the ST group (p = 0.91 and p = 0.74, respectively). CONCLUSIONS: VATS thymectomy was feasible and comparable to sternotomy for the treatment of patients with thymoma with regard to morbidity, incomplete resection rate, and prognosis. However, additional follow-up is required to evaluate long-term outcomes.
Authors: Christian Galata; Stefan Porubsky; Daniel Sebastian Dohle; Ioannis Karampinis; Davor Stamenovic; Eric Dominic Roessner Journal: Mediastinum Date: 2022-03-25