Literature DB >> 28616575

Multiple functions of protein phosphatases in receptor tyrosine kinase signaling revealed by interactome analysis.

Zhong Yao1, Igor Stagljar1,2,3.   

Abstract

To obtain a global picture of how protein phosphatases are involved in receptor tyrosine kinase (RTK) signaling, we mapped the RTK-phosphatase interactome. Analyses of selected interactions revealed detailed mechanisms of their actions. This study provides new knowledge to better understand cancer development and to identify novel therapeutic targets.

Entities:  

Keywords:  Dephosphorylation; MYTH; MaMTH; PTP; RTK; phosphorylation; protein phosphatase; protein-protein interaction; signaling

Year:  2017        PMID： 28616575      PMCID： PMC5462513          DOI： 10.1080/23723556.2017.1297101

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

1.  Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase.

Authors:  X M Zheng; Y Wang; C J Pallen
Journal:  Nature       Date:  1992-09-24       Impact factor: 49.962

2.  The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

Authors:  Julia Petschnigg; Bella Groisman; Max Kotlyar; Mikko Taipale; Yong Zheng; Christoph F Kurat; Azin Sayad; J Rafael Sierra; Mojca Mattiazzi Usaj; Jamie Snider; Alex Nachman; Irina Krykbaeva; Ming-Sound Tsao; Jason Moffat; Tony Pawson; Susan Lindquist; Igor Jurisica; Igor Stagljar
Journal:  Nat Methods       Date:  2014-03-23       Impact factor: 28.547

3.  Application guide for omics approaches to cell signaling.

Authors:  Zhong Yao; Julia Petschnigg; Robin Ketteler; Igor Stagljar
Journal:  Nat Chem Biol       Date:  2015-05-15       Impact factor: 15.040

4.  A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

Authors:  Zhong Yao; Katelyn Darowski; Nicole St-Denis; Victoria Wong; Fabian Offensperger; Annabel Villedieu; Shahreen Amin; Ramy Malty; Hiroyuki Aoki; Hongbo Guo; Yang Xu; Caterina Iorio; Max Kotlyar; Andrew Emili; Igor Jurisica; Benjamin G Neel; Mohan Babu; Anne-Claude Gingras; Igor Stagljar
Journal:  Mol Cell       Date:  2017-01-05       Impact factor: 17.970

5.  A genetic system based on split-ubiquitin for the analysis of interactions between membrane proteins in vivo.

Authors:  I Stagljar; C Korostensky; N Johnsson; S te Heesen
Journal:  Proc Natl Acad Sci U S A       Date:  1998-04-28       Impact factor: 11.205

Review 6.  Cell signaling by receptor tyrosine kinases.

Authors:  Mark A Lemmon; Joseph Schlessinger
Journal:  Cell       Date:  2010-06-25       Impact factor: 41.582

7.  Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells.

Authors:  Hava Gil-Henn; Ari Elson
Journal:  J Biol Chem       Date:  2003-02-21       Impact factor: 5.157

8.  An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis.

Authors:  Gabi Tarcic; Shlomit K Boguslavsky; Jean Wakim; Tai Kiuchi; Angela Liu; Felicia Reinitz; David Nathanson; Takamune Takahashi; Paul S Mischel; Tony Ng; Yosef Yarden
Journal:  Curr Biol       Date:  2009-11-17       Impact factor: 10.834

Review 9.  A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage.

Authors:  Jannik N Andersen; Peter G Jansen; Søren M Echwald; Ole H Mortensen; Toshiyuki Fukada; Robert Del Vecchio; Nicholas K Tonks; Niels Peter H Møller
Journal:  FASEB J       Date:  2004-01       Impact factor: 5.191

Review 10.  Fundamentals of protein interaction network mapping.

Authors:  Jamie Snider; Max Kotlyar; Punit Saraon; Zhong Yao; Igor Jurisica; Igor Stagljar
Journal:  Mol Syst Biol       Date:  2015-12-17       Impact factor: 11.429
  10 in total

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