Literature DB >> 28616574

Therapeutic arginine starvation in ASS1-deficient cancers inhibits the Warburg effect.

Jeff C Kremer1, Brian A Van Tine1,2.   

Abstract

Argininosuccinate Synthetase 1 deficiency induces dependence on extracellular arginine for continued cellular growth and survival. Arginine starvation inhibits the Warburg effect and diverts glucose into serine biosynthesis, while simultaneously increasing glutamine metabolism via the tricarboxylic acid cycle. Simultaneous arginine deprivation and inhibition of the subsequent metabolic adaptations induce synthetic lethality.

Entities:  

Keywords:  ADI-PEG20; ASS1; GLS; PHGDH; Warburg; arginine deiminase; argininosuccinate synthetase 1; glucose; glutaminase; glutamine; metabolism

Year:  2017        PMID： 28616574      PMCID： PMC5462516          DOI： 10.1080/23723556.2017.1295131

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  Yan Long; Wen-Bin Tsai; Medhi Wangpaichitr; Takashi Tsukamoto; Niramol Savaraj; Lynn G Feun; Macus Tien Kuo
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7.  A metabolic synthetic lethal strategy with arginine deprivation and chloroquine leads to cell death in ASS1-deficient sarcomas.

Authors:  Gregory R Bean; Jeff C Kremer; Bethany C Prudner; Aaron D Schenone; Juo-Chin Yao; Matthew B Schultze; David Y Chen; Munir R Tanas; Douglas R Adkins; John Bomalaski; Brian P Rubin; Loren S Michel; Brian A Van Tine
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8.  Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers.

Authors:  Jeff Charles Kremer; Bethany Cheree Prudner; Sara Elaine Stubbs Lange; Gregory Richard Bean; Matthew Bailey Schultze; Caitlyn Brook Brashears; Megan DeAnna Radyk; Nathan Redlich; Shin-Cheng Tzeng; Kenjiro Kami; Laura Shelton; Aixiao Li; Zack Morgan; John Stephen Bomalaski; Takashi Tsukamoto; Jon McConathy; Loren Scott Michel; Jason Matthew Held; Brian Andrew Van Tine
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9.  Monitoring phosphorylation of the pyruvate dehydrogenase complex.

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  10 in total
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5.  A Liquid Chromatography with Tandem Mass Spectrometry-Based Proteomic Analysis of Cells Cultured in DMEM 10% FBS and Chemically Defined Medium Using Human Adipose-Derived Mesenchymal Stem Cells.

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