Literature DB >> 2861456

Calcitonin gene-related peptide: potent vasodilator and major product of calcitonin gene.

S I Girgis, D W Macdonald, J C Stevenson, P J Bevis, C Lynch, S J Wimalawansa, C H Self, H R Morris, I MacIntyre.   

Abstract

In addition to calcitonin and katacalcin, the human calcitonin gene encodes a novel peptide--calcitonin gene-related peptide (CGRP)--a potent vasodilator. A sensitive and specific radioimmunoassay was developed to study plasma levels of CGRP in normal subjects. CGRP circulates at five times the concentration of calcitonin, suggesting that it may be an important physiological regulator of vascular tone and blood flow.

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Year:  1985        PMID： 2861456     DOI： 10.1016/s0140-6736(85)90059-5

Source DB:  PubMed          Journal:  Lancet        ISSN： 0140-6736            Impact factor:   79.321


  22 in total

1.  Calcitonin and bone formation: a knockout full of surprises.

Authors:  Mone Zaidi; Baljit S Moonga; Etsuko Abe
Journal:  J Clin Invest       Date:  2002-12       Impact factor: 14.808

2.  Calcitonin gene-related peptide immunoreactivity in the biliary pathway and liver of the guinea-pig: distribution and colocalization with substance P.

Authors:  L E Goehler; C Sternini; N C Brecha
Journal:  Cell Tissue Res       Date:  1988-07       Impact factor: 5.249

Review 3.  Amylin, amyloid and age-related disease.

Authors:  G J Cooper; C A Tse
Journal:  Drugs Aging       Date:  1996-09       Impact factor: 3.923

4.  Release of calcitonin gene-related peptide from a human medullary carcinoma of the thyroid in vitro.

Authors:  M Ohashi; N Fujio; H Ibayashi
Journal:  Experientia       Date:  1986-07-15

5.  Calcitonin gene-related peptide (CGRP) is a potent non-endothelium-dependent inhibitor of coronary vasomotor tone.

Authors:  B Greenberg; K Rhoden; P Barnes
Journal:  Br J Pharmacol       Date:  1987-12       Impact factor: 8.739

6.  Failure to detect plasma neuropeptide release during trigeminal thermocoagulation.

Authors:  H Schon; D T Thomas; D A Jewkes; M A Ghatei; P K Mulderry; S R Bloom
Journal:  J Neurol Neurosurg Psychiatry       Date:  1987-05       Impact factor: 10.154

7.  Human alpha-calcitonin gene-related peptide (CGRP) is a potent vasodilator in human mesenteric vasculature.

Authors:  I Marshall; S J Al-Kazwini; J J Holman; R K Craig
Journal:  Br J Clin Pharmacol       Date:  1988-12       Impact factor: 4.335

8.  Hypothalamic amenorrhea and cardiovascular hormones: changes of plasma calcitonin gene-related peptide and atrial natriuretic peptide levels.

Authors:  F Bernardi; A Valentini; A Margutti; M Santuz; E C Degli Uberti; F Petraglia; A R Genazzani
Journal:  J Endocrinol Invest       Date:  1998-04       Impact factor: 4.256

9.  Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage.

Authors:  X Wang; T L Yue; F C Barone; R F White; R K Clark; R N Willette; A C Sulpizio; N V Aiyar; R R Ruffolo; G Z Feuerstein
Journal:  Proc Natl Acad Sci U S A       Date:  1995-12-05       Impact factor: 11.205

10.  Sumatriptan does not change calcitonin gene-related peptide in the cephalic and extracephalic circulation in healthy volunteers.

Authors:  Jakob Møller Hansen; Jesper Petersen; Troels Wienecke; Karsten Skovgaard Olsen; Lars Thorbjørn Jensen; Messoud Ashina
Journal:  J Headache Pain       Date:  2009-03-06       Impact factor: 7.277
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