Catherine Kim1, James C Slaughter2, Erica T Wang3, Duke Appiah4, Pamela Schreiner5, Benjamin Leader6, Ronit Calderon-Margalit7, Barbara Sternfeld8, David Siscovick9, Melissa Wellons10. 1. Departments of Medicine and Obstetrics & Gynecology, University of Michigan, USA. Electronic address: cathkim@umich.edu. 2. Department of Biostatistics, Vanderbilt University Medical Center, 2525 West End Avenue, Suite 1100, Nashville, TN 37203-1738, USA. Electronic address: james.c.slaughter@vanderbilt.edu. 3. Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, 444 S. San Vicente Avenue, Suite 1002, Los Angeles, CA 90048, USA. Electronic address: Erica.wang@cshs.org. 4. Division of Epidemiology & Community Health, University of Minnesota, 1300 S, 2nd Street, Suite 300, Minneapolis, MN 55454, USA. 5. Division of Epidemiology & Community Health, University of Minnesota, 1300 S, 2nd Street, Suite 300, Minneapolis, MN 55454, USA. Electronic address: schre012@umn.edu. 6. ReproSource, 300 Trade Center, Suite 6540, Woburn, MA 01801, USA. Electronic address: leader@reprosource.com. 7. Hadassah-Hebrew University Braun School of Public Health, Hadassah Medical Center, PO Box 12272, Jerusalem 91120, Israel. Electronic address: ronitcm@gmail.com. 8. Division of Research, Kaiser Permanente Northern California, 2000 Broadway, Oakland, CA 94612, USA. Electronic address: bsternfeld@gmail.com. 9. New York Academy of Medicine, 1216 5th Ave, New York City, NY 10029, USA. Electronic address: dsiskovick@nyam.org. 10. Department of Medicine, Vanderbilt University, 1215 21st Avenue South MCE-South Tower, Suite 8210, Nashville, TN 37232, USA. Electronic address: Melissa.wellons@vanderbilt.edu.
Abstract
OBJECTIVE: To evaluate the ability of concentration of anti-Müllerian hormone (AMH), antral follicle count (AFC), and concentration of follicle stimulating hormone (FSH) to predict the onset of menopause. STUDY DESIGN: The Coronary Artery Risk Development in Young Adults Study (CARDIA) Women's Study was an ancillary study to CARDIA, a population-based study of adults aged 18-30 years followed for 3 decades. For this report, participants were women (n=426) who had attended the CARDIA year 15-16 (2000-2001) examination, had at least one ovary, were not pregnant, and underwent serum AMH and FSH measurement and transvaginal ultrasonography in 2002-2003. MAIN OUTCOME MEASURES: The probability of menopause in 5 years based upon AMH, FSH, and AFC. RESULTS: The mean age of the women at the time of AMH, FSH, and AFC assessment was 43 years. The cumulative incidence of menopause at 25 years (or follow-up) was 27% (n=426), and the incidence within 5 years was 13% (n=55). Among women aged 45-49 years, undetectable AMH concentrations were associated with a greater than 60% probability of menopause within 5 years, whereas approximately 1/3 of women with no or just one antral follicle experienced menopause within 5 years. Both low and high concentrations of FSH were associated with greater odds of menopause than intermediate concentrations. Models with multiple markers did not improve the prediction of menopause over that afforded by models with single markers. CONCLUSION: The ability to predict onset of menopause was improved with any of the three menopausal markers in addition to age. AMH concentrations were more closely associated with menopause than AFC or FSH.
OBJECTIVE: To evaluate the ability of concentration of anti-Müllerian hormone (AMH), antral follicle count (AFC), and concentration of follicle stimulating hormone (FSH) to predict the onset of menopause. STUDY DESIGN: The Coronary Artery Risk Development in Young Adults Study (CARDIA) Women's Study was an ancillary study to CARDIA, a population-based study of adults aged 18-30 years followed for 3 decades. For this report, participants were women (n=426) who had attended the CARDIA year 15-16 (2000-2001) examination, had at least one ovary, were not pregnant, and underwent serum AMH and FSH measurement and transvaginal ultrasonography in 2002-2003. MAIN OUTCOME MEASURES: The probability of menopause in 5 years based upon AMH, FSH, and AFC. RESULTS: The mean age of the women at the time of AMH, FSH, and AFC assessment was 43 years. The cumulative incidence of menopause at 25 years (or follow-up) was 27% (n=426), and the incidence within 5 years was 13% (n=55). Among women aged 45-49 years, undetectable AMH concentrations were associated with a greater than 60% probability of menopause within 5 years, whereas approximately 1/3 of women with no or just one antral follicle experienced menopause within 5 years. Both low and high concentrations of FSH were associated with greater odds of menopause than intermediate concentrations. Models with multiple markers did not improve the prediction of menopause over that afforded by models with single markers. CONCLUSION: The ability to predict onset of menopause was improved with any of the three menopausal markers in addition to age. AMH concentrations were more closely associated with menopause than AFC or FSH.
Authors: John F Randolph; Sybil Crawford; Lorraine Dennerstein; Kevin Cain; Siobán D Harlow; Roderick Little; Ellen S Mitchell; Bin Nan; John Taffe; Matheos Yosef Journal: J Clin Endocrinol Metab Date: 2006-05-23 Impact factor: 5.958
Authors: MaryFran R Sowers; Huiyong Zheng; Gail A Greendale; Robert M Neer; Jane A Cauley; Jayne Ellis; Sarah Johnson; Joel S Finkelstein Journal: J Clin Endocrinol Metab Date: 2013-05-10 Impact factor: 5.958
Authors: Melissa F Wellons; Gordon Wright Bates; Pamela J Schreiner; David S Siscovick; Barbara Sternfeld; Cora E Lewis Journal: Menopause Date: 2013-08 Impact factor: 2.953
Authors: MaryFran R Sowers; Aimee D Eyvazzadeh; Daniel McConnell; Matheos Yosef; Mary L Jannausch; Daowen Zhang; Sioban Harlow; John F Randolph Journal: J Clin Endocrinol Metab Date: 2008-07-01 Impact factor: 5.958
Authors: MaryFran R Sowers; Huiyong Zheng; Daniel McConnell; Bin Nan; Sioban Harlow; John F Randolph Journal: J Clin Endocrinol Metab Date: 2008-07-22 Impact factor: 5.958
Authors: Candice Y Johnson; Lauren J Tanz; Christina C Lawson; Penelope P Howards; Elizabeth R Bertone-Johnson; A Heather Eliassen; Eva S Schernhammer; Janet W Rich-Edwards Journal: Arch Environ Occup Health Date: 2019-04-04 Impact factor: 1.663
Authors: Catherine Kim; James C Slaughter; James G Terry; David R Jacobs; Nisha Parikh; Duke Appiah; Benjamin Leader; Molly B Moravek; Melissa F Wellons Journal: Fertil Steril Date: 2020-07-16 Impact factor: 7.490
Authors: Joel S Finkelstein; Hang Lee; Arun Karlamangla; Robert M Neer; Patrick M Sluss; Sherri-Ann M Burnett-Bowie; Karin Darakananda; Patricia K Donahoe; Sioban D Harlow; Sarah H Prizand; Hadine Joffe; Ajay Kumar; Deborah E Martin; Daniel McConnell; Steffenie Merrilat; Anthony Morrison; Lisa M Pastore; John F Randolph; Gail A Greendale; Nanette Santoro Journal: J Clin Endocrinol Metab Date: 2020-04-01 Impact factor: 6.134