Literature DB >> 28609652

Paradoxical Effects of MLL Paralogs in MLL-Rearranged Leukemia.

Michael J Thirman1.   

Abstract

Conflicting data exist on the requirement for wild-type MLL1 in MLL-rearranged leukemia. In this issue of Cancer Cell, Chen et al. describe complementary approaches demonstrating that MLL1 is dispensable for MLL-fusion-mediated leukemogenesis. They also observe an unexpected role for MLL2 in MLL-rearranged leukemia cells and identify potential therapeutic targets.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2017        PMID： 28609652      PMCID： PMC5783294          DOI： 10.1016/j.ccell.2017.05.014

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2.

Authors:  C Bach; D Mueller; S Buhl; M P Garcia-Cuellar; R K Slany
Journal:  Oncogene       Date:  2008-12-08       Impact factor: 9.867

2.  Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia.

Authors:  Fang Cao; Elizabeth C Townsend; Hacer Karatas; Jing Xu; Li Li; Shirley Lee; Liu Liu; Yong Chen; Peter Ouillette; Jidong Zhu; Jay L Hess; Peter Atadja; Ming Lei; Zhaohui S Qin; Sami Malek; Shaomeng Wang; Yali Dou
Journal:  Mol Cell       Date:  2014-01-02       Impact factor: 17.970

3.  MLL2: A new mammalian member of the trx/MLL family of genes.

Authors:  K T FitzGerald; M O Diaz
Journal:  Genomics       Date:  1999-07-15       Impact factor: 5.736

4.  MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

Authors:  Yufei Chen; Konstantinos Anastassiadis; Andrea Kranz; A Francis Stewart; Kathrin Arndt; Claudia Waskow; Akihiko Yokoyama; Kenneth Jones; Tobias Neff; Yoo Lee; Patricia Ernst
Journal:  Cancer Cell       Date:  2017-06-12       Impact factor: 31.743

5.  MLL-AF9-induced leukemogenesis requires coexpression of the wild-type Mll allele.

Authors:  Austin T Thiel; Peter Blessington; Tao Zou; Danielle Feather; Xinjiang Wu; Jizhou Yan; Hui Zhang; Zuguo Liu; Patricia Ernst; Gary A Koretzky; Xianxin Hua
Journal:  Cancer Cell       Date:  2010-02-17       Impact factor: 31.743

6.  AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia.

Authors:  Chengqi Lin; Edwin R Smith; Hidehisa Takahashi; Ka Chun Lai; Skylar Martin-Brown; Laurence Florens; Michael P Washburn; Joan W Conaway; Ronald C Conaway; Ali Shilatifard
Journal:  Mol Cell       Date:  2010-02-12       Impact factor: 17.970

7.  Altered Hox expression and segmental identity in Mll-mutant mice.

Authors:  B D Yu; J L Hess; S E Horning; G A Brown; S J Korsmeyer
Journal:  Nature       Date:  1995-11-30       Impact factor: 49.962

8.  Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors.

Authors:  Craig D Jude; Leslie Climer; Diyong Xu; Erika Artinger; Jill K Fisher; Patricia Ernst
Journal:  Cell Stem Cell       Date:  2007-09-13       Impact factor: 24.633

9.  The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis.

Authors:  Stefan Glaser; Sandra Lubitz; Kate L Loveland; Kazu Ohbo; Lorraine Robb; Frieder Schwenk; Jost Seibler; Daniela Roellig; Andrea Kranz; Konstantinos Anastassiadis; A Francis Stewart
Journal:  Epigenetics Chromatin       Date:  2009-04-06       Impact factor: 4.954

10.  The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis.

Authors:  Bibhu P Mishra; Kristin M Zaffuto; Erika L Artinger; Tonis Org; Hanna K A Mikkola; Chao Cheng; Malek Djabali; Patricia Ernst
Journal:  Cell Rep       Date:  2014-05-09       Impact factor: 9.423
  10 in total
  2 in total

Review 1.  Inotuzumab: from preclinical development to success in B-cell acute lymphoblastic leukemia.

Authors:  Joseph Wynne; David Wright; Wendy Stock
Journal:  Blood Adv       Date:  2019-01-08

2.  Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.

Authors:  Heng Zhang; Bo Zhou; Su Qin; Jing Xu; Rachel Harding; Wolfram Tempel; Vinod Nayak; Yanjun Li; Peter Loppnau; Yali Dou; Jinrong Min
Journal:  Genes Dev       Date:  2018-03-21       Impact factor: 11.361
  2 in total

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