Literature DB >> 10409430

MLL2: A new mammalian member of the trx/MLL family of genes.

K T FitzGerald1, M O Diaz.   

Abstract

We have identified a gene at chromosome band 19q13.1, which is closely related to MLL. MLL is located in a region of chromosome 11q23 that has partial synteny with chromosome 19q. We have named this gene at 19q13.1, MLL2. MLL2 encodes a protein that exhibits a high level of similarity to MLL over several important protein domains. MLL2 is also ubiquitously expressed among adult human tissues, as is MLL. MLL is a homologue of the Drosophila gene trithorax (trx), which encodes a regulator of homeotic gene expression. MLL is involved in chromosome rearrangements associated with leukemia in mammals. However, no MLL2 rearrangements associated with leukemia have been recorded. Copyright 1999 Academic Press.

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Year:  1999        PMID： 10409430     DOI： 10.1006/geno.1999.5860

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  38 in total

1.  Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

Authors:  Venkatasubramanian Dharmarajan; Jeong-Heon Lee; Anamika Patel; David G Skalnik; Michael S Cosgrove
Journal:  J Biol Chem       Date:  2012-06-03       Impact factor: 5.157

2.  Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.

Authors:  Paul M Ayton; Everett H Chen; Michael L Cleary
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

3.  Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

Authors:  Irina Issaeva; Yulia Zonis; Tanya Rozovskaia; Kira Orlovsky; Carlo M Croce; Tatsuya Nakamura; Alex Mazo; Lea Eisenbach; Eli Canaani
Journal:  Mol Cell Biol       Date:  2006-12-18       Impact factor: 4.272

4.  Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Authors:  Celina Demers; Chandra-Prakash Chaturvedi; Jeffrey A Ranish; Gaetan Juban; Patrick Lai; Francois Morle; Ruedi Aebersold; F Jeffrey Dilworth; Mark Groudine; Marjorie Brand
Journal:  Mol Cell       Date:  2007-08-17       Impact factor: 17.970

5.  Mirror-image asymmetry in monozygotic twins with kabuki syndrome.

Authors:  A Riess; A Dufke; O Riess; S Beck-Woedl; B Fode; H Skladny; R Klaes; A Tzschach
Journal:  Mol Syndromol       Date:  2012-07-25

6.  CpG binding protein is crucial for early embryonic development.

Authors:  D L Carlone; D G Skalnik
Journal:  Mol Cell Biol       Date:  2001-11       Impact factor: 4.272

Review 7.  Molecular pathogenesis of MLL-associated leukemias.

Authors:  Mariko Eguchi; Minenori Eguchi-Ishimae; Mel Greaves
Journal:  Int J Hematol       Date:  2005-07       Impact factor: 2.490

8.  Epigenetic regulator MLL2 shows altered expression in cancer cell lines and tumors from human breast and colon.

Authors:  Thanemozhi G Natarajan; Bhaskar V Kallakury; Christine E Sheehan; Margaret B Bartlett; Natarajan Ganesan; Anju Preet; Jeffrey S Ross; Kevin T FitzGerald
Journal:  Cancer Cell Int       Date:  2010-04-30       Impact factor: 5.722

9.  Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome.

Authors:  Sarah B Ng; Abigail W Bigham; Kati J Buckingham; Mark C Hannibal; Margaret J McMillin; Heidi I Gildersleeve; Anita E Beck; Holly K Tabor; Gregory M Cooper; Heather C Mefford; Choli Lee; Emily H Turner; Joshua D Smith; Mark J Rieder; Koh-Ichiro Yoshiura; Naomichi Matsumoto; Tohru Ohta; Norio Niikawa; Deborah A Nickerson; Michael J Bamshad; Jay Shendure
Journal:  Nat Genet       Date:  2010-08-15       Impact factor: 38.330

10.  Identification of the RGG box motif in Shadoo: RNA-binding and signaling roles?

Authors:  Susan M Corley; Jill E Gready
Journal:  Bioinform Biol Insights       Date:  2008-11-19
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