Nina Roswall1, Sven-Eric Stangerup2, Per Cayé-Thomasen2,3, Joachim Schüz4, Christoffer Johansen1,5, Steen Solvang Jensen6, Ole Raaschou-Nielsen1,6, Mette Sørensen1. 1. a Danish Cancer Society Research Center , Copenhagen , Denmark. 2. b Department of Oto-rhino-laryngology, Head and Neck Surgery, and Audiology , Copenhagen University Hospital, Rigshospitalet , Copenhagen , Denmark. 3. c Faculty of Health and Medical Sciences , University of Copenhagen , Copenhagen , Denmark. 4. d Section of Environment and Radiation , International Agency for Research on Cancer (IARC), World Health Organization , Lyon , France. 5. e Oncology, Finsen Centre, Rigshospitalet , University of Copenhagen , Copenhagen , Denmark. 6. f Department of Environmental Science , Aarhus University , Roskilde , Denmark.
Abstract
BACKGROUND: Few risk factors for sporadic vestibular schwannoma (VS) are known. Several studies have proposed an increased risk with occupational noise exposure, whereas no studies have investigated residential traffic noise exposure as a risk factor. The present study investigated if residential traffic noise was associated with vestibular schwannoma in a large, population-based Danish case-control study. MATERIAL AND METHODS: We identified 1454 VS cases, age above 30 years at diagnosis, between 1990 and 2007. For each case, we selected two random population controls, matched on sex and year of birth. Road and railway traffic noise at the residence was calculated for all present and historical addresses between 1987 and index date. Associations between traffic noise and risk for VS were estimated using conditional logistic regression, adjusted for education, disposable personal income, cohabitation status, railway noise exposure, municipal population density, and municipal income. RESULTS: A two-year time-weighted mean road traffic noise exposure was associated with an adjusted odds ratio of 0.92 (0.82-1.03) for developing VS, per 10 dB increment. There was no clear trend in categorical analyses. Similarly, linear and categorical analyses of residential railway noise did not suggest an association. We found no interaction with demographics, year of diagnosis, individual and municipal socioeconomic variables, and railway noise exposure. The results did not differ by tumor side, spread or size. CONCLUSIONS: The present study does not suggest an association between residential traffic noise and VS.
BACKGROUND: Few risk factors for sporadic vestibular schwannoma (VS) are known. Several studies have proposed an increased risk with occupational noise exposure, whereas no studies have investigated residential traffic noise exposure as a risk factor. The present study investigated if residential traffic noise was associated with vestibular schwannoma in a large, population-based Danish case-control study. MATERIAL AND METHODS: We identified 1454 VS cases, age above 30 years at diagnosis, between 1990 and 2007. For each case, we selected two random population controls, matched on sex and year of birth. Road and railway traffic noise at the residence was calculated for all present and historical addresses between 1987 and index date. Associations between traffic noise and risk for VS were estimated using conditional logistic regression, adjusted for education, disposable personal income, cohabitation status, railway noise exposure, municipal population density, and municipal income. RESULTS: A two-year time-weighted mean road traffic noise exposure was associated with an adjusted odds ratio of 0.92 (0.82-1.03) for developing VS, per 10 dB increment. There was no clear trend in categorical analyses. Similarly, linear and categorical analyses of residential railway noise did not suggest an association. We found no interaction with demographics, year of diagnosis, individual and municipal socioeconomic variables, and railway noise exposure. The results did not differ by tumor side, spread or size. CONCLUSIONS: The present study does not suggest an association between residential traffic noise and VS.
Authors: John P Marinelli; Christine M Lohse; Brandon R Grossardt; John I Lane; Matthew L Carlson Journal: Otol Neurotol Date: 2020-07 Impact factor: 2.619
Authors: Robert J Macielak; John P Marinelli; Douglas J Totten; Christine M Lohse; Brandon R Grossardt; Matthew L Carlson Journal: Otolaryngol Head Neck Surg Date: 2020-10-27 Impact factor: 5.591