Alice Hoeller1, Laura Ehrlich1, Michaela Golic1,2, Florian Herse2, Frank H Perschel3, Monika Siwetz4, Wolfgang Henrich1, Ralf Dechend2, Berthold Huppertz4, Stefan Verlohren1. 1. a Department of Obstetrics , Charité University Medicine , Berlin , Germany. 2. b HELIOS Clinic, Experimental and Clinical Research Center, Max-Delbrueck Center , Berlin-Buch , Germany. 3. c Laboratory Medicine and Toxicology , Charité University Medicine Berlin und Labor Berlin - Charité, Vivantes GmbH , Berlin , Germany. 4. d Institute of Cell Biology, Histology and Embryology, Medical University of Graz , Graz , Austria.
Abstract
OBJECTIVE: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. METHODS: Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction. CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
OBJECTIVE: To investigate whether differences between early preeclampsia and early fetal growth restriction can be explained by differential placental expression patterns of sFlt-1, Flt-1, and PlGF. METHODS: Placental tissues and maternal blood samples from six cases of preeclampsia, seven IUGR, and six age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. RESULTS: Neither placental PlGF mRNA and protein expression nor placental villous trophoblast expression intensity of PlGF was altered by placental dysfunction. CONCLUSION: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
Authors: Barbara Fuenzalida; Sampada Kallol; Jonas Zaugg; Martin Mueller; Hiten D Mistry; Jaime Gutierrez; Andrea Leiva; Christiane Albrecht Journal: Cells Date: 2022-06-11 Impact factor: 7.666
Authors: Kristin Thiele; Alexandra Maximiliane Hierweger; Julia Isabel Amambay Riquelme; María Emilia Solano; John P Lydon; Petra Clara Arck Journal: Front Endocrinol (Lausanne) Date: 2019-02-25 Impact factor: 5.555
Authors: Nirav Barapatre; Eva Haeussner; David Grynspan; Christoph Schmitz; Franz Edler von Koch; Hans-Georg Frank Journal: Sci Rep Date: 2019-02-20 Impact factor: 4.379
Authors: Jacqueline Bangma; John Szilagyi; Bevin E Blake; Cinthya Plazas; Stewart Kepper; Suzanne E Fenton; Rebecca C Fry Journal: Environ Toxicol Date: 2020-08-13 Impact factor: 4.109
Authors: Pierre-Yves Robillard; Gustaaf Dekker; Marco Scioscia; Francesco Bonsante; Silvia Iacobelli; Malik Boukerrou; Thomas C Hulsey Journal: PLoS One Date: 2019-10-17 Impact factor: 3.240
Authors: Sandra G Heil; Emilie M Herzog; Pieter H Griffioen; Bertrand van Zelst; Sten P Willemsen; Yolanda B de Rijke; Regine P M Steegers-Theunissen; Eric A P Steegers Journal: PLoS One Date: 2019-12-30 Impact factor: 3.240