Literature DB >> 28609

Phenobarbital increases spontaneous transmitter release at the frog neuromuscular junction.

J H Pincus, N F Insler.   

Abstract

Phenobarbital (1-2 × 10(-4)M) markedly increases the frequency of miniature end-plate potentials at the neuromuscular synapse of the frog. This effect was seen in calcium free media containing EGTA. The drug probably acts presynaptically at an intracellular locus to increase the presynaptic free calcium concentration.

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Year:  1978        PMID： 28609      PMCID： PMC2595670     

Source DB:  PubMed          Journal:  Yale J Biol Med        ISSN： 0044-0086


  7 in total

1.  The effect of anesthetic agents on skeletal muscle membrane.

Authors:  S THESLEFF
Journal:  Acta Physiol Scand       Date:  1956-11-05

2.  Mechanism of blockade of neuromuscular transmission by pentobarbital.

Authors:  I Seyama; T Narahashi
Journal:  J Pharmacol Exp Ther       Date:  1975-01       Impact factor: 4.030

3.  Barbiturate-induced changes in transmitter release independent of terminal spike configuration in the frog neuromuscular junction.

Authors:  J N Weakly; W R Proctor
Journal:  Neuropharmacology       Date:  1977 Jul-Aug       Impact factor: 5.250

4.  The release of acetylcholine from nerve endings by graded electric pulses.

Authors:  B Katz; R Miledi
Journal:  Proc R Soc Lond B Biol Sci       Date:  1967-01-31

5.  Tetrodotoxin and neuromuscular transmission.

Authors:  B Katz; R Miledi
Journal:  Proc R Soc Lond B Biol Sci       Date:  1967-01-31

6.  Barbiturate-induced transmitter release at a frog neuromuscular junction.

Authors:  T D Thomson; S A Turkanis
Journal:  Br J Pharmacol       Date:  1973-05       Impact factor: 8.739

7.  A comparison of the presynaptic and post-synaptic actions of pentobarbitone and phenobarbitone in the neuromuscular junction of the frog.

Authors:  W R Proctor; J N Weakly
Journal:  J Physiol       Date:  1976-06       Impact factor: 5.182
  7 in total

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