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Literature DB >> 4353318

Barbiturate-induced transmitter release at a frog neuromuscular junction.

Abstract

1. The influence of barbiturates on neuromuscular transmission at end-plates of frog sartorius muscles was investigated electrophysiologically on preparations bathed in Ringer solution containing a low concentration of calcium and a high concentration of magnesium.2. Effects of a convulsant barbiturate, 5-(2-cyclohexylideneëthyl)-5-ethyl barbituric acid (CHEB), were compared with those of phenobarbitone.3. CHEB and phenobarbitone increased the mean quantum content of the end-plate potentials and decreased the mean amplitude of the miniature end-plate potentials.4. Both barbiturates enhanced the duration of the nerve-terminal action potential and had little or no effect on the effective resistance of the skeletal muscle membrane.

Entities: Chemical

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Year: 1973 PMID： 4353318 PMCID： PMC1776099 DOI： 10.1111/j.1476-5381.1973.tb08221.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

19 in total

Review 5. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.

Authors: R L Macdonald; A B Young
Journal: Mol Cell Biochem Date: 1981-08-11 Impact factor: 3.396

Barbiturate-induced transmitter release at a frog neuromuscular junction.

1. A further study of the statistical composition on the end-plate potential.

2. On the factors which determine the amplitude of the miniature end-plate potential.

3. The distribution and excretion of phenobarbital.

4. The effect of anesthetic agents on skeletal muscle membrane.

5. Effect of barbiturates on 'quantal' synaptic transmission in spinal motoneurones.

6. Effects of a convulsant barbiturate on dorsal root ganglion cells and dorsal root discharges.

7. Modification of transmitter release by electrical interference with motor nerve endings.

8. A study of the excitatory effects of barbiturates.

9. Extrinsic and intrinsic acetylcholine and barbiturate effects on frog skeletal muscle.

10. Modification of transmitter release by ions which prolong the presynaptic action potential.

1. The effects of inert gases and other general anaesthetics on the release of acetylcholine from the guinea-pig ileum.

2. Facilitation of synaptic transmission by general anaesthetics.

3. Input-output relation of transmission through cuneate nucleus.

4. Contractures elicited by tetraethylammonium in avian muscle treated with methohexitone.

Review 5. Pharmacology of GABA-mediated inhibition of spinal cord neurons in vivo and in primary dissociated cell culture.

6. Influence of delta9-tetrahydrocannabinol and cannabidiol on photically evoked after-discharge potentials.

7. Presynaptic and postsynaptic depressant effects of phenytoin sodium at the neuromuscular junction.

8. Drug blockade of open end-plate channels.

9. Pentobarbitone pharmacology of mammalian central neurones grown in tissue culture.

10. Presynaptic action of barbiturates in the frog spinal cord.