Literature DB >> 28608681

Activated Ion-Electron Transfer Dissociation Enables Comprehensive Top-Down Protein Fragmentation.

Nicholas M Riley, Michael S Westphall, Joshua J Coon1.   

Abstract

Here we report the first demonstration of near-complete sequence coverage of intact proteins using activated ion-electron transfer dissociation (AI-ETD), a method that leverages concurrent infrared photoactivation to enhance electron-driven dissociation. AI-ETD produces mainly c/z-type product ions and provides comprehensive (77-97%) protein sequence coverage, outperforming HCD, ETD, and EThcD for all proteins investigated. AI-ETD also maintains this performance across precursor ion charge states, mitigating charge-state dependence that limits traditional approaches.

Entities:  

Keywords:  activated-ion; electron-transfer dissociation; infrared photons; intact proteins; photoactivation; top-down proteomics

Mesh：

Substances：

Year:  2017        PMID： 28608681      PMCID： PMC5555583          DOI： 10.1021/acs.jproteome.7b00249

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  45 in total

1.  Electron capture dissociation for structural characterization of multiply charged protein cations.

Authors:  R A Zubarev; D M Horn; E K Fridriksson; N L Kelleher; N A Kruger; M A Lewis; B K Carpenter; F W McLafferty
Journal:  Anal Chem       Date:  2000-02-01       Impact factor: 6.986

2.  Activated ion electron capture dissociation for mass spectral sequencing of larger (42 kDa) proteins.

Authors:  D M Horn; Y Ge; F W McLafferty
Journal:  Anal Chem       Date:  2000-10-15       Impact factor: 6.986

3.  Top-down mass spectrometry of a 29-kDa protein for characterization of any posttranslational modification to within one residue.

Authors:  Siu Kwan Sze; Ying Ge; HanBin Oh; Fred W McLafferty
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

4.  Kinetic intermediates in the folding of gaseous protein ions characterized by electron capture dissociation mass spectrometry.

Authors:  D M Horn; K Breuker; A J Frank; F W McLafferty
Journal:  J Am Chem Soc       Date:  2001-10-10       Impact factor: 15.419

5.  Detailed unfolding and folding of gaseous ubiquitin ions characterized by electron capture dissociation.

Authors:  Kathrin Breuker; HanBin Oh; David M Horn; Blas A Cerda; Fred W McLafferty
Journal:  J Am Chem Soc       Date:  2002-06-05       Impact factor: 15.419

6.  Plasma electron capture dissociation for the characterization of large proteins by top down mass spectrometry.

Authors:  Siu Kwan Sze; Ying Ge; HanBin Oh; Fred W McLafferty
Journal:  Anal Chem       Date:  2003-04-01       Impact factor: 6.986

7.  Combined infrared multiphoton dissociation and electron capture dissociation with a hollow electron beam in Fourier transform ion cyclotron resonance mass spectrometry.

Authors:  Youri O Tsybin; Matthias Witt; Gökhan Baykut; Frank Kjeldsen; Per Håkansson
Journal:  Rapid Commun Mass Spectrom       Date:  2003       Impact factor: 2.419

8.  Peptide and protein sequence analysis by electron transfer dissociation mass spectrometry.

Authors:  John E P Syka; Joshua J Coon; Melanie J Schroeder; Jeffrey Shabanowitz; Donald F Hunt
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-21       Impact factor: 11.205

Review 9.  Mobile and localized protons: a framework for understanding peptide dissociation.

Authors:  V H Wysocki; G Tsaprailis; L L Smith; L A Breci
Journal:  J Mass Spectrom       Date:  2000-12       Impact factor: 1.982

Review 10.  Electron-capture dissociation tandem mass spectrometry.

Authors:  Roman A Zubarev
Journal:  Curr Opin Biotechnol       Date:  2004-02       Impact factor: 9.740
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  32 in total

1.  The Value of Activated Ion Electron Transfer Dissociation for High-Throughput Top-Down Characterization of Intact Proteins.

Authors:  Nicholas M Riley; Jacek W Sikora; Henrique S Seckler; Joseph B Greer; Ryan T Fellers; Richard D LeDuc; Michael S Westphall; Paul M Thomas; Neil L Kelleher; Joshua J Coon
Journal:  Anal Chem       Date:  2018-07-05       Impact factor: 6.986

2.  Extensive Characterization of Heavily Modified Histone Tails by 193 nm Ultraviolet Photodissociation Mass Spectrometry via a Middle-Down Strategy.

Authors:  Sylvester M Greer; Simone Sidoli; Mariel Coradin; Malena Schack Jespersen; Veit Schwämmle; Ole N Jensen; Benjamin A Garcia; Jennifer S Brodbelt
Journal:  Anal Chem       Date:  2018-08-16       Impact factor: 6.986

3.  Top-Down Analysis of Branched Proteins Using Mass Spectrometry.

Authors:  Dapeng Chen; Fabio Gomes; Dulith Abeykoon; Betsegaw Lemma; Yan Wang; David Fushman; Catherine Fenselau
Journal:  Anal Chem       Date:  2018-03-07       Impact factor: 6.986

4.  Analysis of the topology of ubiquitin chains.

Authors:  Lucia Geis-Asteggiante; Amanda E Lee; Catherine Fenselau
Journal:  Methods Enzymol       Date:  2019-07-13       Impact factor: 1.600

5.  The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics.

Authors:  Yana A Lyon; Dylan Riggs; Luca Fornelli; Philip D Compton; Ryan R Julian
Journal:  J Am Soc Mass Spectrom       Date:  2017-10-16       Impact factor: 3.109

6.  Capillary Zone Electrophoresis-Tandem Mass Spectrometry with Activated Ion Electron Transfer Dissociation for Large-scale Top-down Proteomics.

Authors:  Elijah N McCool; Jean M Lodge; Abdul Rehman Basharat; Xiaowen Liu; Joshua J Coon; Liangliang Sun
Journal:  J Am Soc Mass Spectrom       Date:  2019-05-09       Impact factor: 3.109

Review 7.  Mass Spectrometry Approaches to Glycomic and Glycoproteomic Analyses.

Authors:  L Renee Ruhaak; Gege Xu; Qiongyu Li; Elisha Goonatilleke; Carlito B Lebrilla
Journal:  Chem Rev       Date:  2018-03-19       Impact factor: 60.622

Review 8.  Top-Down Proteomics: Ready for Prime Time?

Authors:  Bifan Chen; Kyle A Brown; Ziqing Lin; Ying Ge
Journal:  Anal Chem       Date:  2017-12-15       Impact factor: 6.986

Review 9.  A Perspective on the Confident Comparison of Glycoprotein Site-Specific Glycosylation in Sample Cohorts.

Authors:  Joshua A Klein; Joseph Zaia
Journal:  Biochemistry       Date:  2019-12-31       Impact factor: 3.162

10.  PEPPI-MS: Polyacrylamide-Gel-Based Prefractionation for Analysis of Intact Proteoforms and Protein Complexes by Mass Spectrometry.

Authors:  Ayako Takemori; David S Butcher; Victoria M Harman; Philip Brownridge; Keisuke Shima; Daisuke Higo; Jun Ishizaki; Hitoshi Hasegawa; Junpei Suzuki; Masakatsu Yamashita; Joseph A Loo; Rachel R Ogorzalek Loo; Robert J Beynon; Lissa C Anderson; Nobuaki Takemori
Journal:  J Proteome Res       Date:  2020-07-11       Impact factor: 4.466
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