Simultaneous monitoring of voltammetric and ion-selective electrodes in mammalian brain.

A new technique of simultaneously recording from ion-selective and voltammetric microelectrodes in vivo allows one to measure concomitant ionic and monoamine neurotransmitter fluxes in the extracellular fluid space of the brain. Examples are presented of the results obtained with various drug and stimulus applications. The time correlations of the ionic and neurotransmitter fluxes are especially useful in attempting to better understand the possible interactions of these chemical dynamics with neuronal functioning.