Claudio Maurizio Pacella1, Giovanni Mauri2, Roberto Cesareo3, Valerio Paqualini3, Roberto Cianni3, Pierpaolo De Feo4, Giovanni Gambelunghe4, Bruno Raggiunti5, Doris Tina5, Maurilio Deandrea6, Pier Paolo Limone6, Alberto Mormile6, Massimo Giusti7, Silvia Oddo7, Gaetano Achille8, Enrico Di Stasio9, Irene Misischi10, Enrico Papini10. 1. a Department of Diagnostic Imaging , "Regina Apostolorum" Hospital , Albano Laziale , Italy. 2. b Department of Interventional Radiology , European Institute of Oncology , Milan , Italy. 3. c Thyroid Disease Center "S.M. Goretti" Hospital , Latina , Italy. 4. d Department of Internal Medicine , University of Perugia , Perugia , Italy. 5. e Endocrinology Unit, Atri Hospital , Atri , Italy. 6. f Thyroid Disease Center "A. Costa" Mauriziano Hospital , Turin , Italy. 7. g Endocrinology Department , AOU-IST IRCSS San Martino University of Genoa , Genoa , Italy. 8. h Cervico-Facial Ultrasound Diagnostic and Interventional Unit , Institute of Oncology of Bari , Bari , Italy. 9. i Institute of Biochemistry and Clinical Biochemistry , Rome Catholic University "Sacro Cuore" , Rome , Italy. 10. j Department of Endocrinology , "Regina Apostolorum" Hospital , Albano Laziale , Italy.
Abstract
PURPOSE: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. MATERIALS AND METHODS: Institutional review board approval was obtained, and patients' consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching. Factors influencing volume reduction at 6 and 12 months and complications were evaluated. RESULTS: No significant differences were observed in the baseline characteristics between groups after propensity score matching adjustment. Mean nodule reduction at 6 and 12 months was -67 ± 19% vs. -57 ± 21% (p < 0.001) - 70 ± 19% vs. -62 ± 22% (p = 0.001) in LA group and in RFA group, respectively. Nodules with volume >30 mL had significantly higher percentage volume reduction at 6 and 12 months (-69 ± 19 vs. -50 ± 21, p = 0.001) and (-73 ± 18 vs. -54 ± 23 8, p = 0.001) in the LA group than in the RFA group, respectively. In both groups, operator's skills affected the results. Major complications occurred in 4 cases in each group (p = 0.116) Conclusions: LA and RFA showed nearly similar outcome but LA was slightly more effective than RFA in large nodules. Operator's skills could be crucial in determining the extent of nodule volume reduction regardless of the used technique.
PURPOSE: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. MATERIALS AND METHODS: Institutional review board approval was obtained, and patients' consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching. Factors influencing volume reduction at 6 and 12 months and complications were evaluated. RESULTS: No significant differences were observed in the baseline characteristics between groups after propensity score matching adjustment. Mean nodule reduction at 6 and 12 months was -67 ± 19% vs. -57 ± 21% (p < 0.001) - 70 ± 19% vs. -62 ± 22% (p = 0.001) in LA group and in RFA group, respectively. Nodules with volume >30 mL had significantly higher percentage volume reduction at 6 and 12 months (-69 ± 19 vs. -50 ± 21, p = 0.001) and (-73 ± 18 vs. -54 ± 23 8, p = 0.001) in the LA group than in the RFA group, respectively. In both groups, operator's skills affected the results. Major complications occurred in 4 cases in each group (p = 0.116) Conclusions: LA and RFA showed nearly similar outcome but LA was slightly more effective than RFA in large nodules. Operator's skills could be crucial in determining the extent of nodule volume reduction regardless of the used technique.
Authors: Pierpaolo Trimboli; Marco Castellana; Luca Maria Sconfienza; Camilla Virili; Lorenzo Carlo Pescatori; Roberto Cesareo; Francesco Giorgino; Roberto Negro; Luca Giovanella; Giovanni Mauri Journal: Endocrine Date: 2019-07-20 Impact factor: 3.633
Authors: Salvatore Gitto; Sotirios Bisdas; Ilaria Emili; Luca Nicosia; Lorenzo Carlo Pescatori; Kunwar Bhatia; Ravi K Lingam; Francesco Sardanelli; Luca Maria Sconfienza; Giovanni Mauri Journal: Endocrine Date: 2019-03-22 Impact factor: 3.633
Authors: Antonio Barile; Simone Quarchioni; Federico Bruno; Anna Maria Ierardi; Francesco Arrigoni; Aldo Victor Giordano; Sergio Carducci; Marco Varrassi; Giampaolo Carrafiello; Ferdinando Caranci; Alessandra Splendiani; Ernesto Di Cesare; Carlo Masciocchi Journal: Gland Surg Date: 2018-04
Authors: Salvatore Gitto; Giorgia Grassi; Chiara De Angelis; Cristian Giuseppe Monaco; Silvana Sdao; Francesco Sardanelli; Luca Maria Sconfienza; Giovanni Mauri Journal: Radiol Med Date: 2018-09-22 Impact factor: 3.469