Vishnu Parthasarathy1, Darvis T Frazier2, Brianne M Bettcher3, Laura Jastrzab2, Linda Chao4, Bruce Reed5, Dan Mungas5, Michael Weiner6, Charles DeCarli5, Helena Chui7, Joel H Kramer2. 1. Department of Emergency Medicine, University of California, San Diego. 2. Memory and Aging Center, University of California, San Francisco. 3. Anschutz School of Medicine, University of Colorado. 4. Department of Radiology, University of California, San Francisco. 5. Alzheimer's Disease Research Center, University of California, Davis. 6. Center for Imaging of Neurodegenerative Diseases, University of California, San Francisco. 7. Department of Neurology, University of Southern California.
Abstract
OBJECTIVE: Vascular risk factors like hyperlipidemia may adversely affect brain function. We hypothesized that increased serum triglycerides are associated with decreased executive function and memory in nondemented elderly subjects. We also researched possible vascular mediators and white matter microstructure as assessed with diffusion tensor imaging (DTI). DESIGN/ METHOD: Participants were 251 nondemented elderly adults (54% male) with a mean age of 78 (SD = 6.4; range: 62-94) years and a mean education of 15.6 (SD = 2.9; range: 8-23) years. Fasting blood samples were used to detect serum triglyceride and low-density lipoprotein (LDL) levels along with ApoE4 status. DTI was used to determine whole brain fractional anisotropy (FA). Composite executive and memory scores were derived from item response theory. Clinical Dementia Rating (CDR) scores provided informant-based measures of daily functioning. RESULTS: Triglyceride levels were inversely correlated with executive function, but there was no relationship with memory. Controlling for age, gender, and education did not affect this correlation. This relationship persisted after controlling for vascular risk factors like LDL, total cholesterol, CDR and ApoE4 status. Lastly, adding whole-brain FA to the model did not affect the correlation between triglycerides and executive function. CONCLUSION: Triglyceride levels are inversely correlated with executive function in nondemented elderly adults after controlling for age, education, gender, total cholesterol, LDL, ApoE4 status, CDR, and white-matter microstructure. The fact that the effect of triglycerides on cognition was not clearly mediated by vascular risks or cerebrovascular injury raises questions about widely held assumptions of how triglycerides might impact cognition function. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
OBJECTIVE: Vascular risk factors like hyperlipidemia may adversely affect brain function. We hypothesized that increased serum triglycerides are associated with decreased executive function and memory in nondemented elderly subjects. We also researched possible vascular mediators and white matter microstructure as assessed with diffusion tensor imaging (DTI). DESIGN/ METHOD:Participants were 251 nondemented elderly adults (54% male) with a mean age of 78 (SD = 6.4; range: 62-94) years and a mean education of 15.6 (SD = 2.9; range: 8-23) years. Fasting blood samples were used to detect serum triglyceride and low-density lipoprotein (LDL) levels along with ApoE4 status. DTI was used to determine whole brain fractional anisotropy (FA). Composite executive and memory scores were derived from item response theory. Clinical Dementia Rating (CDR) scores provided informant-based measures of daily functioning. RESULTS:Triglyceride levels were inversely correlated with executive function, but there was no relationship with memory. Controlling for age, gender, and education did not affect this correlation. This relationship persisted after controlling for vascular risk factors like LDL, total cholesterol, CDR and ApoE4 status. Lastly, adding whole-brain FA to the model did not affect the correlation between triglycerides and executive function. CONCLUSION:Triglyceride levels are inversely correlated with executive function in nondemented elderly adults after controlling for age, education, gender, total cholesterol, LDL, ApoE4 status, CDR, and white-matter microstructure. The fact that the effect of triglycerides on cognition was not clearly mediated by vascular risks or cerebrovascular injury raises questions about widely held assumptions of how triglycerides might impact cognition function. (PsycINFO Database Record (c) 2017 APA, all rights reserved).
Authors: Darvis T Frazier; Brianne M Bettcher; Shubir Dutt; Nihar Patel; Dan Mungas; Joshua Miller; Ralph Green; Joel H Kramer Journal: J Int Neuropsychol Soc Date: 2015-08-14 Impact factor: 2.892
Authors: Riccardo E Marioni; Marlene C Stewart; Gordon D Murray; Ian J Deary; F Gerry R Fowkes; Gordon D O Lowe; Ann Rumley; Jackie F Price Journal: Psychosom Med Date: 2009-08-06 Impact factor: 4.312
Authors: Julian N Trollor; Evelyn Smith; Emmeline Agars; Stacey A Kuan; Bernhard T Baune; Lesley Campbell; Katherine Samaras; John Crawford; Ora Lux; Nicole A Kochan; Henry Brodaty; Perminder Sachdev Journal: Age (Dordr) Date: 2011-08-19
Authors: Anna L Marsland; Karen L Petersen; Rama Sathanoori; Matthew F Muldoon; Serina A Neumann; Christopher Ryan; Janine D Flory; Stephen B Manuck Journal: Psychosom Med Date: 2006 Nov-Dec Impact factor: 4.312
Authors: C DeCarli; D G Murphy; M Tranh; C L Grady; J V Haxby; J A Gillette; J A Salerno; A Gonzales-Aviles; B Horwitz; S I Rapoport Journal: Neurology Date: 1995-11 Impact factor: 9.910
Authors: Iván Rentería; Patricia Concepción García-Suárez; José Moncada-Jiménez; Juan Pablo Machado-Parra; Barbara Moura Antunes; Fabio Santos Lira; Alberto Jiménez-Maldonado Journal: Front Nutr Date: 2022-04-28
Authors: Melissa Lamar; Ramon A Durazo-Arvizu; Carlos J Rodriguez; Robert C Kaplan; Marisa J Perera; Jianwen Cai; Rebeca A Espinoza Giacinto; Hector M González; Martha L Daviglus Journal: J Int Neuropsychol Soc Date: 2019-09-23 Impact factor: 2.892
Authors: Faria Sanjana; Peyton L Delgorio; Lucy V Hiscox; Theodore M DeConne; Joshua C Hobson; Matthew L Cohen; Curtis L Johnson; Christopher R Martens Journal: J Cereb Blood Flow Metab Date: 2020-10-26 Impact factor: 6.200
Authors: Ágnes Péterfalvi; Nándor Németh; Róbert Herczeg; Tamás Tényi; Attila Miseta; Boldizsár Czéh; Maria Simon Journal: Front Psychol Date: 2019-08-06
Authors: Karel M Lopez-Vilaret; Jose L Cantero; Marina Fernandez-Alvarez; Miguel Calero; Olga Calero; Mónica Lindín; Montserrat Zurrón; Fernando Díaz; Mercedes Atienza Journal: Aging (Albany NY) Date: 2021-11-03 Impact factor: 5.682