Arnaud Paré1, Pierre Blanchard2, Silvia Rosellini3, Anne Aupérin3, Philippe Gorphe4, Odile Casiraghi5, Stéphane Temam4, François Bidault6, Philippe Page7, Frédéric Kolb4, François Janot4, Antoine Moya Plana8. 1. Department of Head and Neck Surgical Oncology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France; Department of Maxillo Facial and Facial Plastic Surgery, Trousseau Hospital, University of François Rabelais, Tours, France. 2. Department of Radiation Oncology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France. 3. Department of Biostatistics and Epidemiology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France. 4. Department of Head and Neck Surgical Oncology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France. 5. Department of Pathology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France. 6. Department of Radiology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France. 7. Department of Neurosurgery, Sainte Anne Hospital, University of Paris Descartes, Paris, France. 8. Department of Head and Neck Surgical Oncology, Gustave Roussy Cancer Campus, University of Paris Sud, Villejuif, France. Electronic address: antoine.MOYA-PLANA@gustaveroussy.fr.
Abstract
BACKGROUND: Poor prognosis of sinonasal cancers (SNC) is usually due to the non-specific symptoms leading to late diagnosis with locally advanced disease. However, previous prognostic studies were often based on heterogeneous cohorts because of the scarcity of SNC. With squamous cell carcinoma being the main histological subgroup, the study aimed to perform a prognostic analysis on sinonasal squamous cell carcinoma (SNSCC) particularly, and to evaluate the oncological results of a multimodal therapy. METHODS: A retrospective review of 68 cases involving SNSCC treatment between 1998 and 2012 at Gustave Roussy Cancer Campus was performed. Clinical, pathological, and treatment characteristics were evaluated as prognostic markers for oncological outcomes. RESULTS: The 5-year overall survival (OS) and progression-free survival (PFS) rates were 58.1% and 52.6% respectively. Tumor downsizing under neoadjuvant chemotherapy (NACT) was observed in 82.5% of cases. The main pattern of recurrence was local with a 2- and 5-year rate of 37.3%. Decreased OS, PFS and local control were associated with involvement of the orbit, the soft tissue, and the suprastructure (p < 0.005). CONCLUSION: Prognosis of surgically treated SNSCC remains poor. Multimodal treatment combining NACT followed by wide resection requiring complex reconstruction and adjuvant radiation therapy seems to provide promising results.
BACKGROUND: Poor prognosis of sinonasal cancers (SNC) is usually due to the non-specific symptoms leading to late diagnosis with locally advanced disease. However, previous prognostic studies were often based on heterogeneous cohorts because of the scarcity of SNC. With squamous cell carcinoma being the main histological subgroup, the study aimed to perform a prognostic analysis on sinonasal squamous cell carcinoma (SNSCC) particularly, and to evaluate the oncological results of a multimodal therapy. METHODS: A retrospective review of 68 cases involving SNSCC treatment between 1998 and 2012 at Gustave Roussy Cancer Campus was performed. Clinical, pathological, and treatment characteristics were evaluated as prognostic markers for oncological outcomes. RESULTS: The 5-year overall survival (OS) and progression-free survival (PFS) rates were 58.1% and 52.6% respectively. Tumor downsizing under neoadjuvant chemotherapy (NACT) was observed in 82.5% of cases. The main pattern of recurrence was local with a 2- and 5-year rate of 37.3%. Decreased OS, PFS and local control were associated with involvement of the orbit, the soft tissue, and the suprastructure (p < 0.005). CONCLUSION: Prognosis of surgically treated SNSCC remains poor. Multimodal treatment combining NACT followed by wide resection requiring complex reconstruction and adjuvant radiation therapy seems to provide promising results.
Authors: Dauren Adilbay; Cristina Valero; Conall Fitzgerald; Avery Yuan; Ximena Mimica; Piyush Gupta; Richard J Wong; Jatin P Shah; Snehal G Patel; Ian Ganly; Marc A Cohen Journal: Head Neck Date: 2022-01-25 Impact factor: 3.147
Authors: Anuraag S Parikh; Jennifer C Fuller; Ashton E Lehmann; Neerav Goyal; Stacey T Gray; Derrick T Lin Journal: J Neurol Surg B Skull Base Date: 2020-05-19