BACKGROUND: Sinonasal malignancies are a complex and diverse group of tumors. Over the past five decades, treatment advances have changed the management paradigms for these tumors. Our aim was to analyze the outcomes of patients from a comprehensive cancer center. MATERIALS AND METHODS: We retrospectively assessed 400 patients with sinonasal malignancies treated with surgery at our center between 1973 and 2015. Multiple variables were reviewed to assess the influence on 5-year outcomes. RESULTS: The median age was 56 years (IQR 46.8-68). Two hundred and fifty-nine (65%) were males and 141 (35%) were females. Overall survival (OS) and disease-specific survival (DSS) improved in the last analyzed decade. Orbital invasion, advanced pT-classification and pN-classification, and melanoma histology were associated with poorer outcomes. CONCLUSION: Treatment outcomes for patients with sinonasal malignancy have improved over time. This is likely multifactorial with advances in surgical technique, adjuvant treatment, and patient selection. pT-classification, pN-classification, orbital invasion, and histology are predictive of survival.
BACKGROUND: Sinonasal malignancies are a complex and diverse group of tumors. Over the past five decades, treatment advances have changed the management paradigms for these tumors. Our aim was to analyze the outcomes of patients from a comprehensive cancer center. MATERIALS AND METHODS: We retrospectively assessed 400 patients with sinonasal malignancies treated with surgery at our center between 1973 and 2015. Multiple variables were reviewed to assess the influence on 5-year outcomes. RESULTS: The median age was 56 years (IQR 46.8-68). Two hundred and fifty-nine (65%) were males and 141 (35%) were females. Overall survival (OS) and disease-specific survival (DSS) improved in the last analyzed decade. Orbital invasion, advanced pT-classification and pN-classification, and melanoma histology were associated with poorer outcomes. CONCLUSION: Treatment outcomes for patients with sinonasal malignancy have improved over time. This is likely multifactorial with advances in surgical technique, adjuvant treatment, and patient selection. pT-classification, pN-classification, orbital invasion, and histology are predictive of survival.
Authors: Ian Ganly; Snehal G Patel; Bhuvanesh Singh; Dennis H Kraus; Patrick G Bridger; Giulo Cantu; Anthony Cheesman; Geraldo De Sa; Paul Donald; Dan M Fliss; Patrick Gullane; Ivo Janecka; Shin-Etsu Kamata; Luiz P Kowalski; Paul A Levine; Luiz R Medina dos Santos; Sultan Pradhan; Victor Schramm; Carl Snyderman; William I Wei; Jatin P Shah Journal: Arch Otolaryngol Head Neck Surg Date: 2006-01
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Authors: Ian Ganly; Snehal G Patel; Bhuvanesh Singh; Dennis H Kraus; Patrick G Bridger; Giulo Cantu; Anthony Cheesman; Geraldo De Sa; Paul Donald; Dan Fliss; Patrick Gullane; Ivo Janecka; Shin-etsu Kamata; Luiz P Kowalski; Paul Levine; Luiz R Medina; Sultan Pradhan; Victor Schramm; Carl Snyderman; William I Wei; Jatin P Shah Journal: Head Neck Date: 2005-06 Impact factor: 3.147
Authors: Ian Ganly; Snehal G Patel; Bhuvanesh Singh; Dennis H Kraus; Patrick G Bridger; Giulo Cantu; Anthony Cheesman; Geraldo De Sa; Paul Donald; Dan M Fliss; Patrick Gullane; Ivo Janecka; Shin-Etsu Kamata; Luiz P Kowalski; Paul A Levine; Luiz R Medina Dos Santos; Sultan Pradhan; Victor Schramm; Carl Snyderman; William I Wei; Jatin P Shah Journal: Head Neck Date: 2005-07 Impact factor: 3.147
Authors: Mauricio A Moreno; Dianna B Roberts; Michael E Kupferman; Franco DeMonte; Adel K El-Naggar; Michelle Williams; David S Rosenthal; Ehab Y Hanna Journal: Cancer Date: 2010-05-01 Impact factor: 6.860
Authors: Bradford S Hoppe; Lauren D Stegman; Michael J Zelefsky; Kenneth E Rosenzweig; Suzanne L Wolden; Snehal G Patel; Jatin P Shah; Dennis H Kraus; Nancy Y Lee Journal: Int J Radiat Oncol Biol Phys Date: 2006-12-08 Impact factor: 7.038
Authors: Ming Fan; Jung Julie Kang; Anna Lee; Dan Fan; Huili Wang; Sarin Kitpanit; Pamela Fox; Kevin Sine; Dennis Mah; Sean M McBride; Chiaojung Jillian Tsai; Nadeem Riaz; Lara A Dunn; Eric J Sherman; Loren Michel; Bhuvanesh Singh; Ian Ganly; Richard J Wong; Jay O Boyle; Marc A Cohen; Nancy Y Lee Journal: Cancer Date: 2020-02-25 Impact factor: 6.860
Authors: Joseph Califano; Peter G Cordeiro; Joseph J Disa; David A Hidalgo; Wilson DuMornay; Mark H Bilsky; Philip H Gutin; Jatin P Shah; Dennis H Kraus Journal: Head Neck Date: 2003-02 Impact factor: 3.147