Literature DB >> 28600340

Ethical considerations in genomic testing for hematologic disorders.

Jonathan M Marron1,2,3,4, Steven Joffe5,6,7.   

Abstract

As our technological capacities improve, genomic testing is increasingly integrating into patient care. The field of clinical hematology is no exception. Genomic testing carries great promise, but several ethical issues must be considered whenever such testing is performed. This review addresses these ethical considerations, including issues surrounding informed consent and the uncertainty of the results of genomic testing; the challenge of incidental findings; and possible inequities in access to and benefit from such testing. Genomic testing is likely to transform the practice of both benign and malignant hematology, but clinicians must carefully consider these core ethical issues in order to make the most of this exciting and evolving technology.
© 2017 by The American Society of Hematology.

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Year:  2017        PMID: 28600340      PMCID: PMC5533200          DOI: 10.1182/blood-2017-01-734558

Source DB:  PubMed          Journal:  Blood        ISSN: 0006-4971            Impact factor:   22.113


  77 in total

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Journal:  Blood       Date:  2011-12-09       Impact factor: 22.113

2.  The coming explosion in genetic testing--is there a duty to recontact?

Authors:  Reed E Pyeritz
Journal:  N Engl J Med       Date:  2011-10-13       Impact factor: 91.245

3.  JAK2(V617F): Prevalence in a large Chinese hospital population.

Authors:  Xuesong Xu; Qi Zhang; Jian Luo; Shu Xing; Qingshan Li; Sanford B Krantz; Xueqi Fu; Zhizhuang Joe Zhao
Journal:  Blood       Date:  2006-08-31       Impact factor: 22.113

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Authors:  Christian Säfken; Andreas Frewer
Journal:  HEC Forum       Date:  2007-12

5.  Misinterpretation of TPMT by a DTC genetic testing company.

Authors:  C A Brownstein; D M Margulies; S F Manzi
Journal:  Clin Pharmacol Ther       Date:  2014-03-12       Impact factor: 6.875

6.  The JAK2 V617F somatic mutation, mortality and cancer risk in the general population.

Authors:  Camilla Nielsen; Henrik S Birgens; Børge G Nordestgaard; Lasse Kjaer; Stig E Bojesen
Journal:  Haematologica       Date:  2010-12-15       Impact factor: 9.941

7.  Point-counterpoint. Ethics and genomic incidental findings.

Authors:  Amy L McGuire; Steven Joffe; Barbara A Koenig; Barbara B Biesecker; Laurence B McCullough; Jennifer S Blumenthal-Barby; Timothy Caulfield; Sharon F Terry; Robert C Green
Journal:  Science       Date:  2013-05-16       Impact factor: 47.728

8.  Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience.

Authors:  Jonathan M Marron; Steven G DuBois; Julia Glade Bender; AeRang Kim; Brian D Crompton; Stephanie C Meyer; Katherine A Janeway; Jennifer W Mack
Journal:  Pediatr Blood Cancer       Date:  2016-07-18       Impact factor: 3.167

9.  Return of results to the families of children in genomic sequencing: tallying risks and benefits.

Authors:  James P Evans
Journal:  Genet Med       Date:  2013-06       Impact factor: 8.822

10.  Technical report: Ethical and policy issues in genetic testing and screening of children.

Authors:  Lainie Friedman Ross; Laine Friedman Ross; Howard M Saal; Karen L David; Rebecca R Anderson
Journal:  Genet Med       Date:  2013-02-21       Impact factor: 8.822

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  6 in total

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Authors:  Seth J Rotz; Eric Kodish
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2018-11-30

Review 2.  Hematological Malignancies in Adults With a Family Predisposition.

Authors:  Tilmann Bochtler; Georg-Martin Haag; Sarah Schott; Matthias Kloor; Alwin Krämer; Carsten Müller-Tidow
Journal:  Dtsch Arztebl Int       Date:  2018-12-14       Impact factor: 5.594

3.  Ethics Consultation in Oncology: The Search for Quality in Quantity.

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Journal:  JCO Oncol Pract       Date:  2022-08-10

Review 4.  Approach Toward Germline Predisposition Syndromes in Patients with Hematologic Malignancies.

Authors:  Himachandana Atluri; Yoheved S Gerstein; Courtney D DiNardo
Journal:  Curr Hematol Malig Rep       Date:  2022-10-24       Impact factor: 4.213

5.  Structural Racism in the COVID-19 Pandemic: Don't Forget about the Children!

Authors:  Jonathan M Marron
Journal:  Am J Bioeth       Date:  2021-03       Impact factor: 14.676

6.  Development of a Precision Medicine Workflow in Hematological Cancers, Aalborg University Hospital, Denmark.

Authors:  Julie S Bødker; Mads Sønderkær; Charles Vesteghem; Alexander Schmitz; Rasmus F Brøndum; Mia Sommer; Anne S Rytter; Marlene M Nielsen; Jakob Madsen; Paw Jensen; Inge S Pedersen; Lykke Grubach; Marianne T Severinsen; Anne S Roug; Tarec C El-Galaly; Karen Dybkær; Martin Bøgsted
Journal:  Cancers (Basel)       Date:  2020-01-29       Impact factor: 6.639

  6 in total

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