Literature DB >> 28599458

Epithelial-mesenchymal transition in cancer: Role of the IL-8/IL-8R axis.

Zhiwei Zhao1, Shichao Wang1,2, Yingbo Lin3, Yali Miao4, Ye Zeng1, Yongmei Nie2, Peng Guo1, Guangyao Jiang5, Jiang Wu1,2.   

Abstract

Epithelial-mesenchymal transition (EMT) is a biological process that is associated with cancer metastasis and invasion. In cancer, EMT promotes cell motility, invasion and distant metastasis. Interleukin (IL)-8 is highly expressed in tumors and may induce EMT. The IL-8/IL-8R axis has a vital role in EMT in carcinoma, which is regulated by several signaling pathways, including the transforming growth factor β-spleen associated tyrosine kinase/Src-AKT/extracellular signal-regulated kinase, p38/Jun N-terminal kinase-activating transcription factor-2, phosphoinositide 3-kinase/AKT, nuclear factor-κB and Wnt signaling pathways. Blocking the IL-8/IL-8R signaling pathway may be a novel strategy to reduce metastasis and improve patient survival rates. This review will cover IL-8-IL-8R signaling pathway in tumor epithelial-mesenchymal transition.

Entities:  

Keywords:  C-X-C motif chemokine receptor 1; C-X-C motif chemokine receptor 2; epithelial-mesenchymal transition; interleukin-8; metastasis; prognosis

Year:  2017        PMID： 28599458      PMCID： PMC5453110          DOI： 10.3892/ol.2017.6034

Source DB:  PubMed          Journal:  Oncol Lett        ISSN： 1792-1074            Impact factor:   2.967


  112 in total

1.  Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation.

Authors:  Luika A Timmerman; Joaquín Grego-Bessa; Angel Raya; Esther Bertrán; José María Pérez-Pomares; Juan Díez; Sergi Aranda; Sergio Palomo; Frank McCormick; Juan Carlos Izpisúa-Belmonte; José Luis de la Pompa
Journal:  Genes Dev       Date:  2003-12-30       Impact factor: 11.361

Review 2.  The ins and outs of the epithelial to mesenchymal transition in health and disease.

Authors:  M Angela Nieto
Journal:  Annu Rev Cell Dev Biol       Date:  2011-07-08       Impact factor: 13.827

3.  The Epstein-Barr virus causes epithelial-mesenchymal transition in human corneal epithelial cells via Syk/src and Akt/Erk signaling pathways.

Authors:  Ga Bin Park; Daejin Kim; Yeong Seok Kim; Seonghan Kim; Hyun-Kyung Lee; Jae Wook Yang; Dae Young Hur
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-03-20       Impact factor: 4.799

4.  IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells.

Authors:  Romaine I Fernando; Marianne D Castillo; Mary Litzinger; Duane H Hamilton; Claudia Palena
Journal:  Cancer Res       Date:  2011-06-08       Impact factor: 12.701

5.  Nonapical and cytoplasmic expression of interleukin-8, CXCR1, and CXCR2 correlates with cell proliferation and microvessel density in prostate cancer.

Authors:  Catherine Murphy; Maryalice McGurk; Johanna Pettigrew; Alfredo Santinelli; Roberta Mazzucchelli; Patrick G Johnston; Rodolfo Montironi; David J J Waugh
Journal:  Clin Cancer Res       Date:  2005-06-01       Impact factor: 12.531

6.  Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts.

Authors:  E K Rofstad; E F Halsør
Journal:  Cancer Res       Date:  2000-09-01       Impact factor: 12.701

7.  Interleukin-8 promotes human ovarian cancer cell migration by epithelial-mesenchymal transition induction in vitro.

Authors:  J Yin; F Zeng; N Wu; K Kang; Z Yang; H Yang
Journal:  Clin Transl Oncol       Date:  2014-11-06       Impact factor: 3.405

8.  CCL20 and CXCL8 synergize to promote progression and poor survival outcome in patients with colorectal cancer by collaborative induction of the epithelial-mesenchymal transition.

Authors:  Xian-Shuo Cheng; Yun-Feng Li; Jing Tan; Bin Sun; You-Chuan Xiao; Xing-Bao Fang; Xiao-Feng Zhang; Qiang Li; Jian-Hua Dong; Ming Li; Hai-hua Qian; Zheng-Feng Yin; Zhi-Bin Yang
Journal:  Cancer Lett       Date:  2014-03-18       Impact factor: 8.679

9.  Interleukin-8 as a macrophage-derived mediator of angiogenesis.

Authors:  A E Koch; P J Polverini; S L Kunkel; L A Harlow; L A DiPietro; V M Elner; S G Elner; R M Strieter
Journal:  Science       Date:  1992-12-11       Impact factor: 47.728

10.  Slug is a direct Notch target required for initiation of cardiac cushion cellularization.

Authors:  Kyle Niessen; YangXin Fu; Linda Chang; Pamela A Hoodless; Deborah McFadden; Aly Karsan
Journal:  J Cell Biol       Date:  2008-07-28       Impact factor: 10.539
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  13 in total

1.  RNAi-mediated human Nestin silence inhibits proliferation and migration of malignant melanoma cells by G1/S arrest via Akt-GSK3β-Rb pathway.

Authors:  Xu-Hui Yang; Tian Xia; Jie Zhang; Shao-Fen Yang; Hui-Xia Tang; Ting Tang; Zhi-Cheng Huang; Yue-Si Zhong; Feng He; Andy Peng Xiang
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2017-12-21

2.  Identification of the interleukin-8 (CXCL-8) pathway in feline oral squamous cell carcinoma - A pilot study.

Authors:  Leah H Ackerman; Carlos H de Mello Souza; Galaxia Cortés-Hinojosa; Marc E Salute; Alexa A Stephen; Elizabeth Anthony; Keijiro Shiomitsu; Rowan J Milner
Journal:  Can J Vet Res       Date:  2022-01       Impact factor: 0.897

3.  Interleukin-8 Dedifferentiates Primary Human Luminal Cells to Multipotent Stem Cells.

Authors:  Huda H Al-Khalaf; Hazem Ghebeh; Salma M Wakil; Falah Al-Mohanna; Abdelilah Aboussekhra
Journal:  Mol Cell Biol       Date:  2020-04-13       Impact factor: 4.272

Review 4.  Chemokines orchestrate tumor cells and the microenvironment to achieve metastatic heterogeneity.

Authors:  Sugandha Saxena; Rakesh K Singh
Journal:  Cancer Metastasis Rev       Date:  2021-05-06       Impact factor: 9.264

5.  A Wnt-mediated phenotype switch along the epithelial-mesenchymal axis defines resistance and invasion downstream of ionising radiation in oral squamous cell carcinoma.

Authors:  Fatemeh Zolghadr; Nigel Tse; Dikasya Loka; George Joun; Sreelakshmi Meppat; Victor Wan; Hans Zoellner; Munira Xaymardan; Camile S Farah; J Guy Lyons; Eric Hau; Ellis Patrick; Naisana Seyedasli
Journal:  Br J Cancer       Date:  2021-03-30       Impact factor: 9.075

6.  Tumour-derived transforming growth factor-β signalling contributes to fibrosis in patients with cancer cachexia.

Authors:  Joanna D C C Lima; Estefania Simoes; Gabriela de Castro; Mychel Raony P T Morais; Emidio M de Matos-Neto; Michele J Alves; Nelson I Pinto; Raquel G Figueredo; Telma M T Zorn; Aloísio S Felipe-Silva; Flavio Tokeshi; José P Otoch; Paulo Alcantara; Fernanda J Cabral; Emer S Ferro; Alessandro Laviano; Marilia Seelaender
Journal:  J Cachexia Sarcopenia Muscle       Date:  2019-07-04       Impact factor: 12.910

7.  Role of MCP-1 and IL-8 in viral anterior uveitis, and contractility and fibrogenic activity of trabecular meshwork cells.

Authors:  Jiyoung Lee; Jin A Choi; Hyun-Hee Ju; Ju-Eun Kim; Soon-Young Paik; Ponugoti Vasantha Rao
Journal:  Sci Rep       Date:  2021-07-22       Impact factor: 4.379

Review 8.  Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy.

Authors:  Tareq Saleh; Liliya Tyutynuk-Massey; Emmanuel K Cudjoe; Michael O Idowu; Joseph W Landry; David A Gewirtz
Journal:  Front Oncol       Date:  2018-05-18       Impact factor: 6.244

9.  BCG-induced cytokine release in bladder cancer cells is regulated by Ca2+ signaling.

Authors:  Cristián Ibarra; Marie Karlsson; Simone Codeluppi; Manuel Varas-Godoy; Songbai Zhang; Lauri Louhivuori; Sara Mangsbo; Arad Hosseini; Navid Soltani; Rahim Kaba; T Kalle Lundgren; Abolfazl Hosseini; Nobuyuki Tanaka; Mototsugu Oya; Peter Wiklund; Ayako Miyakawa; Per Uhlén
Journal:  Mol Oncol       Date:  2018-12-13       Impact factor: 6.603

Review 10.  Immunomodulating Activity and Therapeutic Effects of Short Chain Fatty Acids and Tryptophan Post-biotics in Inflammatory Bowel Disease.

Authors:  Edda Russo; Francesco Giudici; Camilla Fiorindi; Ferdinando Ficari; Stefano Scaringi; Amedeo Amedei
Journal:  Front Immunol       Date:  2019-11-22       Impact factor: 7.561
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