Literature DB >> 28599188

Mast cell leukemia (MCL): Clinico-pathologic and molecular features and survival outcome.

Preetesh Jain1, Sa Wang2, Keyur P Patel2, Nawid Sarwari1, Jorge Cortes1, Hagop Kantarjian1, Srdan Verstovsek3.   

Abstract

Mast cell leukemia (MCL) is a very rare subtype of systemic mastocytosis (SM). We have identified 13 such patients (5.9%) among 218 patients with SM seen at our institution between 1994 and 2016. Patients with MCL had poor survival (median 31.6 months); response to various therapies was rare and not durable. Clinical course may be affected by concurrent associated hematologic neoplasm and different genetic profiles. More research is required to decipher this rare and enigmatic SM subtype.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Mast cell leukemia; Systemic mastocytosis

Mesh:

Year:  2017        PMID: 28599188      PMCID: PMC5573652          DOI: 10.1016/j.leukres.2017.05.018

Source DB:  PubMed          Journal:  Leuk Res        ISSN: 0145-2126            Impact factor:   3.156


  10 in total

1.  ASXL1 and CBL mutations are independently predictive of inferior survival in advanced systemic mastocytosis.

Authors:  Animesh D Pardanani; Terra L Lasho; Christy Finke; Darci L Zblewski; Ramy A Abdelrahman; Emnet A Wassie; Naseema Gangat; Curtis A Hanson; Rhett P Ketterling; Ayalew Tefferi
Journal:  Br J Haematol       Date:  2015-12-02       Impact factor: 6.998

2.  Hematopoietic stem-cell transplantation for advanced systemic mastocytosis.

Authors:  Celalettin Ustun; Andreas Reiter; Bart L Scott; Ryotaro Nakamura; Gandhi Damaj; Sebastian Kreil; Ryan Shanley; William J Hogan; Miguel-Angel Perales; Tsiporah Shore; Herrad Baurmann; Robert Stuart; Bernd Gruhn; Michael Doubek; Jack W Hsu; Eleni Tholouli; Tanja Gromke; Lucy A Godley; Livio Pagano; Andrew Gilman; Eva Maria Wagner; Tor Shwayder; Martin Bornhäuser; Esperanza B Papadopoulos; Alexandra Böhm; Gregory Vercellotti; Maria Teresa Van Lint; Christoph Schmid; Werner Rabitsch; Vinod Pullarkat; Faezeh Legrand; Ibrahim Yakoub-Agha; Wael Saber; John Barrett; Olivier Hermine; Hans Hagglund; Wolfgang R Sperr; Uday Popat; Edwin P Alyea; Steven Devine; H Joachim Deeg; Daniel Weisdorf; Cem Akin; Peter Valent
Journal:  J Clin Oncol       Date:  2014-08-25       Impact factor: 44.544

3.  Mast cell leukemia: a report of ten cases.

Authors:  Caterina Giovanna Valentini; Michela Rondoni; Enrico Maria Pogliani; Maria Teresa Van Lint; Chiara Cattaneo; Laura Marbello; Alessandro Pulsoni; Fiorina Giona; Giovanni Martinelli; Giuseppe Leone; Livio Pagano
Journal:  Ann Hematol       Date:  2008-01-03       Impact factor: 3.673

4.  Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors.

Authors:  Ken-Hong Lim; Ayalew Tefferi; Terra L Lasho; Christy Finke; Mrinal Patnaik; Joseph H Butterfield; Rebecca F McClure; Chin-Yang Li; Animesh Pardanani
Journal:  Blood       Date:  2009-04-10       Impact factor: 22.113

5.  Comprehensive mutational profiling in advanced systemic mastocytosis.

Authors:  Juliana Schwaab; Susanne Schnittger; Karl Sotlar; Christoph Walz; Alice Fabarius; Markus Pfirrmann; Alexander Kohlmann; Vera Grossmann; Manja Meggendorfer; Hans-Peter Horny; Peter Valent; Mohamad Jawhar; Martina Teichmann; Georgia Metzgeroth; Philipp Erben; Thomas Ernst; Andreas Hochhaus; Torsten Haferlach; Wolf-Karsten Hofmann; Nicholas C P Cross; Andreas Reiter
Journal:  Blood       Date:  2013-08-19       Impact factor: 22.113

6.  Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis.

Authors:  Jason Gotlib; Hanneke C Kluin-Nelemans; Tracy I George; Cem Akin; Karl Sotlar; Olivier Hermine; Farrukh T Awan; Elizabeth Hexner; Michael J Mauro; David W Sternberg; Matthieu Villeneuve; Alice Huntsman Labed; Eric J Stanek; Karin Hartmann; Hans-Peter Horny; Peter Valent; Andreas Reiter
Journal:  N Engl J Med       Date:  2016-06-30       Impact factor: 91.245

7.  Splenomegaly, elevated alkaline phosphatase and mutations in the SRSF2/ASXL1/RUNX1 gene panel are strong adverse prognostic markers in patients with systemic mastocytosis.

Authors:  M Jawhar; J Schwaab; D Hausmann; J Clemens; N Naumann; T Henzler; H-P Horny; K Sotlar; S O Schoenberg; N C P Cross; A Fabarius; W-K Hofmann; P Valent; G Metzgeroth; A Reiter
Journal:  Leukemia       Date:  2016-07-15       Impact factor: 11.528

Review 8.  Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

Authors:  Peter Valent; Cem Akin; Karin Hartmann; Gunnar Nilsson; Andreas Reiter; Olivier Hermine; Karl Sotlar; Wolfgang R Sperr; Luis Escribano; Tracy I George; Hanneke C Kluin-Nelemans; Celalettin Ustun; Massimo Triggiani; Knut Brockow; Jason Gotlib; Alberto Orfao; Lawrence B Schwartz; Sigurd Broesby-Olsen; Carsten Bindslev-Jensen; Petri T Kovanen; Stephen J Galli; K Frank Austen; Daniel A Arber; Hans-Peter Horny; Michel Arock; Dean D Metcalfe
Journal:  Cancer Res       Date:  2017-03-02       Impact factor: 12.701

Review 9.  Mast cell leukemia.

Authors:  Sophie Georgin-Lavialle; Ludovic Lhermitte; Patrice Dubreuil; Marie-Olivia Chandesris; Olivier Hermine; Gandhi Damaj
Journal:  Blood       Date:  2012-12-14       Impact factor: 22.113

10.  The clinical and molecular diversity of mast cell leukemia with or without associated hematologic neoplasm.

Authors:  Mohamad Jawhar; Juliana Schwaab; Manja Meggendorfer; Nicole Naumann; Hans-Peter Horny; Karl Sotlar; Torsten Haferlach; Karla Schmitt; Alice Fabarius; Peter Valent; Wolf-Karsten Hofmann; Nicholas C P Cross; Georgia Metzgeroth; Andreas Reiter
Journal:  Haematologica       Date:  2017-03-02       Impact factor: 9.941

  10 in total
  4 in total

Review 1.  The international consensus classification of mastocytosis and related entities.

Authors:  Roos J Leguit; Sa A Wang; Tracy I George; Alexandar Tzankov; Attilio Orazi
Journal:  Virchows Arch       Date:  2022-10-10       Impact factor: 4.535

2.  Acute Mast Cell Leukemia Preceded by Malignant Mediastinal Germ Cell Tumor: A Case Report and Literature Review.

Authors:  Huafang Wang; Yuan Chen; Huijun Lin; Wanmao Ni; Qiaolei Zhang; Jianping Lan; Lai Jin
Journal:  Cancer Manag Res       Date:  2022-05-23       Impact factor: 3.602

3.  Evolution of myelodisplasic syndrome with ring sideroblasts (MDS-RS) to systemic mastocytosis and aleukemic mast cell leukemia.

Authors:  Larissa da Costa; Ana Paula de Azambuja; Erica Sabrine Ângelo Lisboa; Silvia Natalia Bueno; Elenaide Nunes Coutinho; Bruno Francisco Buzinetti Spinelli; Larissa Alessandra Medeiros; Vaneuza de Araujo Moreira Funke; Mariester Malvezzi
Journal:  Hematol Transfus Cell Ther       Date:  2019-10-10

4.  Acute aleukemic mast cell leukemia: Report of a case and review of the literature.

Authors:  Gian M Galura; Sundar V Cherukuri; Nawar Hakim; Sumit Gaur; Attilio Orazi
Journal:  Leuk Res Rep       Date:  2020-11-26
  4 in total

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