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Literature DB >> 28595088

The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.

Emily E Carol¹, Robert L Spencer², Vijay A Mittal³.

Abstract

Recent studies have posited a relationship between cannabis use and the biological stress system, but this critical relationship has not been evaluated during the ultra high-risk (UHR) period immediately preceding the onset of psychotic disorders. Salivary cortisol samples were collected on 46 UHR and 29 control adolescents; these individuals were assessed for current cannabis use with a urine panel and self-report. UHR participants where separated into two groups: Current Cannabis Use (UHR-CU) and No Current Cannabis Use (UHR-NC). Healthy Control participants (HC) were free of cannabis use. Consistent with the literature, results indicate UHR individuals showed elevated cortisol levels when compared to HC participants. Further, we also observed that UHR-CU participants exhibited elevated levels when compared to both the non-using UHR and HC groups. Findings suggest that cannabis use may interact with underlying biological vulnerability associated with the hypothalamic-pituitary-adrenal (HPA) axis system. Published by Elsevier Ltd.

Entities: Chemical Disease Gene Species

Keywords: Cannabis; Cortisol; HPA axis; High-Risk; Prodrome; Schizophrenia

Mesh：

Substances：
Hydrocortisone

Year: 2017 PMID： 28595088 PMCID： PMC5531192 DOI： 10.1016/j.psyneuen.2017.04.017

Source DB: PubMed Journal: Psychoneuroendocrinology ISSN： 0306-4530 Impact factor: 4.905

57 in total

1. Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB.

Authors: M Egertová; M R Elphick
Journal: J Comp Neurol Date: 2000-06-26 Impact factor: 3.215

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Authors: C S Martin; N K Pollock; O G Bukstein; K G Lynch
Journal: Drug Alcohol Depend Date: 2000-05-01 Impact factor: 4.492

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Authors: Betty J Buchan; Michael L Dennis; Frank M Tims; Guy S Diamond
Journal: Addiction Date: 2002-12 Impact factor: 6.526

4. Identifying co-occurring substance use disorders in community mental health centres. Tailored approaches are needed.

Authors: Linda Elise Wüsthoff; Helge Waal; Torleif Ruud; Jo Røislien; Rolf W Gråwe
Journal: Nord J Psychiatry Date: 2010-05-28 Impact factor: 2.202

Review 5. Cannabis use and transition to psychosis in individuals at ultra-high risk: review and meta-analysis.

Authors: T Kraan; E Velthorst; L Koenders; K Zwaart; H K Ising; D van den Berg; L de Haan; M van der Gaag
Journal: Psychol Med Date: 2015-11-16 Impact factor: 7.723

Review 6. Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis.

Authors: M N Hill; J G Tasker
Journal: Neuroscience Date: 2011-12-24 Impact factor: 3.590

7. Prospective study of cannabis use in adolescents at clinical high risk for psychosis: impact on conversion to psychosis and functional outcome.

Authors: A M Auther; D McLaughlin; R E Carrión; P Nagachandran; C U Correll; B A Cornblatt
Journal: Psychol Med Date: 2012-04-30 Impact factor: 7.723

8. Stress biomarkers as predictors of transition to psychosis in at-risk mental states: roles for cortisol, prolactin and albumin.

Authors: Javier Labad; Alexander Stojanovic-Pérez; Itziar Montalvo; Montse Solé; Ángel Cabezas; Laura Ortega; Irene Moreno; Elisabet Vilella; Lourdes Martorell; Rebecca M Reynolds; Alfonso Gutiérrez-Zotes
Journal: J Psychiatr Res Date: 2014-11-11 Impact factor: 4.791

The relationship between cannabis use and cortisol levels in youth at ultra high-risk for psychosis.

1. Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB.

2. Inter-rater reliability of the SCID alcohol and substance use disorders section among adolescents.

3. Cannabis use: consistency and validity of self-report, on-site urine testing and laboratory testing.

4. Identifying co-occurring substance use disorders in community mental health centres. Tailored approaches are needed.

Review 5. Cannabis use and transition to psychosis in individuals at ultra-high risk: review and meta-analysis.

Review 6. Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis.

7. Prospective study of cannabis use in adolescents at clinical high risk for psychosis: impact on conversion to psychosis and functional outcome.

8. Stress biomarkers as predictors of transition to psychosis in at-risk mental states: roles for cortisol, prolactin and albumin.

Review 9. Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review.

Review 10. Abnormalities in neuroendocrine stress response in psychosis: the role of endocannabinoids.

Review 1. A review of the effects of acute and chronic cannabinoid exposure on the stress response.

2. Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.

Review 3. Marijuana Use and Hypothalamic-Pituitary-Adrenal Axis Functioning in Humans.

4. Cannabis vapor self-administration elicits sex- and dose-specific alterations in stress reactivity in rats.

Review 5. Glucocorticoids, Stress and Delta-9 Tetrahydrocannabinol (THC) during Early Embryonic Development.