| Literature DB >> 28585836 |
Ruowen Wang1,2, Cheng Jin1, Xiaoyan Zhu1, Liyi Zhou1, Wenjing Xuan1, Yuan Liu1,2, Qiaoling Liu1, Weihong Tan1,2.
Abstract
In contrast to small molecules, DNA and RNA macromolecules can be accurately formulated with base "elements" abbreviated as A, T, U, C, and G. However, the development of functionally artificial bases can result in the generation of new biomaterials with unique properties and applications. Therefore, we herein report the design and synthesis of a photoresponsive base as a new functional or molecular "element" for constructing DNA nanomolecules. The new base is made by fusion of an azobenzene with a natural T base (zT). zT, a new molecular element, is not only the most size-expanded T analogue but also a photoresponsive base capable of specific self-assembly through hydrogen bonding. Our results showed that stable and selective self-assembly of double-stranded DNAs occurred through zT-A base pairing, but it could still be efficiently dissociated by light irradiation. The photoresponsive DNA bases will provide the versatility required for constructing desired DNA nanomolecules and nanodevices.Entities:
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Year: 2017 PMID： 28585836 PMCID： PMC5877792 DOI： 10.1021/jacs.7b02865
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419