I L Gade1, S K Braekkan2,3, I A Naess4, J-B Hansen2,3, S C Cannegieter5, K Overvad6,7, H Jensvoll2,3, J Hammerstrøm8, K Blix2,3, A Tjønneland9, S R Kristensen1,10, M T Severinsen1,11. 1. Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. 2. Department of Clinical Medicine, K. G. Jebsen Thrombosis Research and Expertise Center (TREC), UiT The Arctic University of Norway, Tromsø, Norway. 3. Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway. 4. Department of Hematology, Trondheim University Hospital, Trondheim, Norway. 5. Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. 6. Department of Public Health, Section for Epidemiology, Aarhus University, Aarhus, Denmark. 7. Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. 8. Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway. 9. Diet, Genes and Environment, Danish Cancer Society Research Center, Copenhagen, Denmark. 10. Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark. 11. Department of Hematology, Aalborg University Hospital, Aalborg, Denmark.
Abstract
Essentials Impact of cancer stage on venous thromboembolism (VTE) risk is not well-known in all cancers. The Scandinavian Thrombosis and Cancer Cohort provides person-time data and validated VTEs. Impact of cancer stage on VTE incidence tended to vary with cancer type. Cancer stage may not per se be a risk factor for VTE in all cancer types. SUMMARY: Background Absolute measures of the impact of cancer stage on the incidence of venous thromboembolism (VTE) in patients with distinct cancer types have not been investigated in a large population-based cohort study. Objectives To investigate differences in the incidence rates of objectively confirmed VTE according to the development of cancer in a large population-based cohort study. Cancer type and stage at the time of diagnosis were taken into account. Patients and Methods The Scandinavian Thrombosis and Cancer Cohort includes data regarding cancer types, stages and objectively confirmed VTE diagnoses among 144 952 participants followed from 1993 to 2012. We studied stage-specific incidence rates of VTE, and calculated incidence rate differences (IRDs) for VTE according to stages in patients with 10 types of solid cancer. Results During the entire follow-up, 335 VTEs occurred, of which 293 occurred within 5 years. The IRD of VTE in patients with distant metastasis as compared with those with localized disease indicated large variation depending on cancer type. The highest IRD was observed for pancreatic cancer (IRD of 187.0 × 10-3 person-years [p-y]; 95% confidence interval [CI] - 6.7 to 380.8), and the lowest IRD was observed for prostate cancer (IRD of 3.7 × 10-3 p-y; 95% CI - 7 to 15.2). Regional spread as compared with localized disease also indicated large variation depending on cancer type; the highest IRD was observed for uterine cancer (IRD of 37.6 × 10-3 p-y; 95% CI - 23.7 to 99), and the IRDs for breast and prostate cancer were close to zero. Conclusion More advanced cancer at the time of diagnosis was associated with a higher risk of VTE, but the strength of the associations differed substantially between cancer types.
Essentials Impact of cancer stage on venous thromboembolism (VTE) risk is not well-known in all cancers. The Scandinavian Thrombosis and Cancer Cohort provides person-time data and validated VTEs. Impact of cancer stage on VTE incidence tended to vary with cancer type. Cancer stage may not per se be a risk factor for VTE in all cancer types. SUMMARY: Background Absolute measures of the impact of cancer stage on the incidence of venous thromboembolism (VTE) in patients with distinct cancer types have not been investigated in a large population-based cohort study. Objectives To investigate differences in the incidence rates of objectively confirmed VTE according to the development of cancer in a large population-based cohort study. Cancer type and stage at the time of diagnosis were taken into account. Patients and Methods The Scandinavian Thrombosis and Cancer Cohort includes data regarding cancer types, stages and objectively confirmed VTE diagnoses among 144 952 participants followed from 1993 to 2012. We studied stage-specific incidence rates of VTE, and calculated incidence rate differences (IRDs) for VTE according to stages in patients with 10 types of solid cancer. Results During the entire follow-up, 335 VTEs occurred, of which 293 occurred within 5 years. The IRD of VTE in patients with distant metastasis as compared with those with localized disease indicated large variation depending on cancer type. The highest IRD was observed for pancreatic cancer (IRD of 187.0 × 10-3 person-years [p-y]; 95% confidence interval [CI] - 6.7 to 380.8), and the lowest IRD was observed for prostate cancer (IRD of 3.7 × 10-3 p-y; 95% CI - 7 to 15.2). Regional spread as compared with localized disease also indicated large variation depending on cancer type; the highest IRD was observed for uterine cancer (IRD of 37.6 × 10-3 p-y; 95% CI - 23.7 to 99), and the IRDs for breast and prostate cancer were close to zero. Conclusion More advanced cancer at the time of diagnosis was associated with a higher risk of VTE, but the strength of the associations differed substantially between cancer types.
Authors: Hunter B Moore; Alessandro Paniccia; Peter J Lawson; Robert J Torphy; Trevor L Nydam; Ernest E Moore; Martin D McCarter; Richard D Schulick; Barish H Edil Journal: J Am Coll Surg Date: 2018-03-30 Impact factor: 6.113
Authors: Spyridon Xynogalos; David Simeonidis; George Papageorgiou; Abraham Pouliakis; Nikolaos Charalambakis; Evangelos Lianos; Evridiki Mazlimoglou; Alexandros-Nikolaos Liatsos; Christos Kosmas; Nicolaos Ziras Journal: Support Care Cancer Date: 2022-05-12 Impact factor: 3.359