Literature DB >> 28584182

FOXM1 in Cancer: Interactions and Vulnerabilities.

Andrei L Gartel1.   

Abstract

FOXM1 is a transcription factor of the Forkhead family that is required for cell proliferation of normal cells. However, FOXM1 is repeatedly overexpressed in a variety of human cancers, and it has been implicated in all major hallmarks of cancer delineated by Hanahan and Weinberg. It has been postulated that the oncogenic potential of FOXM1 is determined by its capacity to transactivate target genes that are implicated in different phases of cancer development. However, FOXM1 may also play an oncogenic role by interacting with other proteins, such as β-catenin or SMAD3 to induce oncogenic WNT and TGFβ signaling pathways, respectively. In this review, I will discuss the protein-protein interactions of FOXM1 that are critical for cancer development and may represent novel targets for anticancer drugs. Cancer Res; 77(12); 3135-9. ©2017 AACR. ©2017 American Association for Cancer Research.

Entities:  

Mesh：

Substances：

Year:  2017        PMID： 28584182      PMCID： PMC5519300          DOI： 10.1158/0008-5472.CAN-16-3566

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  30 in total

1.  Identification and validation of commonly overexpressed genes in solid tumors by comparison of microarray data.

Authors:  Christian Pilarsky; Michael Wenzig; Thomas Specht; Hans Detlev Saeger; Robert Grützmann
Journal:  Neoplasia       Date:  2004 Nov-Dec       Impact factor: 5.715

2.  Cross-species regulatory network analysis identifies a synergistic interaction between FOXM1 and CENPF that drives prostate cancer malignancy.

Authors:  Alvaro Aytes; Antonina Mitrofanova; Celine Lefebvre; Mariano J Alvarez; Mireia Castillo-Martin; Tian Zheng; James A Eastham; Anuradha Gopalan; Kenneth J Pienta; Michael M Shen; Andrea Califano; Cory Abate-Shen
Journal:  Cancer Cell       Date:  2014-05-12       Impact factor: 31.743

3.  Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-β-dependent cancer metastasis.

Authors:  Jianfei Xue; Xia Lin; Wen-Tai Chiu; Yao-Hui Chen; Guanzhen Yu; Mingguang Liu; Xin-Hua Feng; Raymond Sawaya; René H Medema; Mien-Chie Hung; Suyun Huang
Journal:  J Clin Invest       Date:  2014-01-02       Impact factor: 14.808

Review 4.  Maternal embryonic leucine zipper kinase: key kinase for stem cell phenotype in glioma and other cancers.

Authors:  Ranjit Ganguly; Christopher S Hong; Luke G F Smith; Harley I Kornblum; Ichiro Nakano
Journal:  Mol Cancer Ther       Date:  2014-05-02       Impact factor: 6.261

5.  Nucleophosmin interacts with FOXM1 and modulates the level and localization of FOXM1 in human cancer cells.

Authors:  Uppoor G Bhat; Ramasamy Jagadeeswaran; Marianna Halasi; Andrei L Gartel
Journal:  J Biol Chem       Date:  2011-10-06       Impact factor: 5.157

6.  Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin.

Authors:  H Quentmeier; M P Martelli; W G Dirks; N Bolli; A Liso; R A F Macleod; I Nicoletti; R Mannucci; A Pucciarini; B Bigerna; M F Martelli; C Mecucci; H G Drexler; B Falini
Journal:  Leukemia       Date:  2005-10       Impact factor: 11.528

Review 7.  FOX(M1) news--it is cancer.

Authors:  Marianna Halasi; Andrei L Gartel
Journal:  Mol Cancer Ther       Date:  2013-02-26       Impact factor: 6.261

8.  Pro-proliferative FoxM1 is a target of p53-mediated repression.

Authors:  A M Barsotti; C Prives
Journal:  Oncogene       Date:  2009-09-14       Impact factor: 9.867

9.  FoxM1 is a general target for proteasome inhibitors.

Authors:  Uppoor G Bhat; Marianna Halasi; Andrei L Gartel
Journal:  PLoS One       Date:  2009-08-12       Impact factor: 3.240

Review 10.  The role of the orphan nuclear receptor COUP-TFII in tumorigenesis.

Authors:  Mafei Xu; Jun Qin; Sophia Y Tsai; Ming-jer Tsai
Journal:  Acta Pharmacol Sin       Date:  2014-10-06       Impact factor: 6.150
View more
  74 in total

1.  Inhibition of EZH2 and activation of ERRγ synergistically suppresses gastric cancer by inhibiting FOXM1 signaling pathway.

Authors:  Boyan Huang; Peiqiang Mu; Yan Yu; Wenya Zhu; Tianqing Jiang; Rong Deng; Gongkan Feng; Jikai Wen; Xiaofeng Zhu; Yiqun Deng
Journal:  Gastric Cancer       Date:  2020-06-11       Impact factor: 7.370

Review 2.  Targeting forkhead box M1 transcription factor in breast cancer.

Authors:  Ruth M O'Regan; Rita Nahta
Journal:  Biochem Pharmacol       Date:  2018-05-31       Impact factor: 5.858

3.  Paeoniflorin inhibits cell growth and induces cell cycle arrest through inhibition of FoxM1 in colorectal cancer cells.

Authors:  Meng Yue; Shiquan Li; Guoqiang Yan; Chenyao Li; Zhenhua Kang
Journal:  Cell Cycle       Date:  2018-01-05       Impact factor: 4.534

4. 

Authors:  Botao Fa; Chengwen Luo; Zhou Tang; Yuting Yan; Yue Zhang; Zhangsheng Yu
Journal:  EBioMedicine       Date:  2019-05-14       Impact factor: 8.143

5.  Downregulation of FoxM1 inhibits cell growth and migration and invasion in bladder cancer cells.

Authors:  Xinping Yang; Yuanyuan Shi; Jingzhe Yan; Haitao Fan
Journal:  Am J Transl Res       Date:  2018-02-15       Impact factor: 4.060

6.  UCHL3 promotes pancreatic cancer progression and chemo-resistance through FOXM1 stabilization.

Authors:  Zhiwang Song; Junhe Li; Ling Zhang; Jun Deng; Ziling Fang; Xiaojun Xiang; Jianping Xiong
Journal:  Am J Cancer Res       Date:  2019-09-01       Impact factor: 6.166

7.  Activation of AMPK inhibits Galectin-3-induced pulmonary artery smooth muscle cells proliferation by upregulating hippo signaling effector YAP.

Authors:  Qianqian Zhang; Wenge Li; Yanting Zhu; Qingting Wang; Cui Zhai; Wenhua Shi; Wei Feng; Jian Wang; Xin Yan; Limin Chai; Yuqian Chen; Cong Li; Pengtao Liu; Manxiang Li
Journal:  Mol Cell Biochem       Date:  2021-04-02       Impact factor: 3.396

8.  FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells.

Authors:  Zuhal Hamurcu; Nesrin Delibaşı; Ufuk Nalbantoglu; Elif Funda Sener; Nursultan Nurdinov; Bayram Tascı; Serpil Taheri; Yusuf Özkul; Hamiyet Donmez-Altuntas; Halit Canatan; Bulent Ozpolat
Journal:  J Mol Med (Berl)       Date:  2019-02-07       Impact factor: 4.599

9.  Identification of Hub Genes Associated With Melanoma Development by Comprehensive Bioinformatics Analysis.

Authors:  Jie Jiang; Chong Liu; Guoyong Xu; Tuo Liang; Chaojie Yu; Shian Liao; Zide Zhang; Zhaojun Lu; Zequn Wang; Jiarui Chen; Tianyou Chen; Hao Li; Xinli Zhan
Journal:  Front Oncol       Date:  2021-04-12       Impact factor: 6.244

10.  Reciprocal Regulation Between Forkhead Box M1/NF-κB and Methionine Adenosyltransferase 1A Drives Liver Cancer.

Authors:  Yuan Li; Liqing Lu; Jian Tu; Jing Zhang; Ting Xiong; Wei Fan; Jiaohong Wang; Meng Li; Yibu Chen; Justin Steggerda; Hui Peng; Yongheng Chen; Tony W H Li; Zhi-Gang Zhou; José M Mato; Ekihiro Seki; Ting Liu; Heping Yang; Shelly C Lu
Journal:  Hepatology       Date:  2020-10-01       Impact factor: 17.425
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.