Taskin Duman1, Derya Uluduz2, Ipek Midi3, Hesna Bektas4, Yuksel Kablan5, Basak K Goksel6, Aysel Milanlioglu7, Dilek Necioglu Orken8, Ufuk Aluclu9. 1. Department of Neurology, School of Medicine, Mustafa Kemal University, Hatay, Turkey. 2. Department of Neurology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: deryauluduz2015@gmail.com. 3. Department of Neurology, School of Medicine, Marmara University, Istanbul, Turkey. 4. Clinic of Neurology, Ataturk Research and Training Hospital, Ankara, Turkey. 5. Department of Neurology, School of Medicine, Inonu University, Malatya, Turkey. 6. Department of Neurology, School of Medicine, Baskent University, Adana, Turkey. 7. Department of Neurology, School of Medicine, Yüzüncü Yıl University, Van, Turkey. 8. Clinic of Neurology, Sisli Hamidiye Etfal Research and Training Hospital, Istanbul, Turkey. 9. Department of Neurology, School of Medicine, Dicle University, Diyarbakır, Turkey.
Abstract
BACKGROUND: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. METHODS: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. RESULTS: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epileptic seizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epileptic seizures had no effect on prognosis. CONCLUSIONS: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome.
BACKGROUND: Based on a number of small observational studies, cerebral venous sinus thrombosis has diverse clinical and imaging features, risk factors, and variable outcome. In a large, multicenter cerebral venous thrombosis (VENOST) study, we sought to more precisely characterize the clinical characteristics of Caucasian patients. METHODS: All data for the VENOST study were collected between the years 2000 and 2015 from the clinical follow-up files. Clinical and radiological characteristics, risk factors, and outcomes were compared in terms of age and sex distribution. RESULTS: Among 1144 patients 68% were women, and in older age group (>50 years) male patients were more prevalent (16.6% versus 27.8%). The most frequent symptoms were headache (89.4%) and visual field defects (28.9%) in men, and headache (86.1%) and epilepticseizures (26.8%) in women. Gynecological factors comprised the largest group in women, in particular puerperium (18.3%). Prothrombotic conditions (26.4%), mainly methylenetetrahydrofolate reductase mutation (6.3%) and Factor V Leiden mutation (5.1%), were the most common etiologies in both genders. 8.1% of patients had infection-associated and 5.2% had malignancy-related etiology that was significantly higher in men and older age group. Parenchymal involvement constitutively hemorrhagic infarcts, malignancy, and older age was associated with higher Rankin score. Epilepticseizures had no effect on prognosis. CONCLUSIONS: Clinical and radiological findings were consistent with previous larger studies but predisposing factors were different with a higher incidence of puerperium. Oral contraceptive use was not a prevalent risk factor in our cohort. Malignancy, older age, and hemorrhagic infarcts had worse outcome.
Authors: John H Zhang; Andre Obenaus; David S Liebeskind; Jiping Tang; Richard Hartman; William J Pearce Journal: J Cereb Blood Flow Metab Date: 2017-09-19 Impact factor: 6.200
Authors: Julia Devianne; Nicolas Legris; Isabelle Crassard; Celine Bellesme; Yannick Bejot; Celine Guidoux; Fernando Pico; David Germanaud; Michael Obadia; Diana Rodriguez; Philippe Tuppin; Manoelle Kossorotoff; Christian Denier Journal: Neurology Date: 2021-09-20 Impact factor: 9.910