Literature DB >> 28582496

Vaginal Candida spp. genomes from women with vulvovaginal candidiasis.

L Latéy Bradford1,2, Marcus C Chibucos1,2, Bing Ma1,2, Vincent Bruno1,2, Jacques Ravel1,2.   

Abstract

Candida albicans is the predominant cause of vulvovaginal candidiasis (VVC). Little is known regarding the genetic diversity of Candida spp. in the vagina or the microvariations in strains over time that may contribute to the development of VVC. This study reports the draft genome sequences of four C. albicans and one C. glabrata strains isolated from women with VVC. An SNP-based whole-genome phylogeny indicates that these isolates are closely related; however, phylogenetic distances between them suggest that there may be genetic adaptations driven by unique host environments. These sequences will facilitate further comparative analyses and ultimately improve our understanding of genetic variation in isolates of Candida spp. that are associated with VVC. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  Candida albicans; Candida glabrata; clinical isolates; single nucleotide polymorphisms (SNP); yeast infection

Mesh：

Substances：

Year:  2017        PMID： 28582496      PMCID： PMC5827580          DOI： 10.1093/femspd/ftx061

Source DB:  PubMed          Journal:  Pathog Dis        ISSN： 2049-632X            Impact factor:   3.166


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Review 4.  Pathogenesis and epidemiology of vulvovaginal candidiasis.

Authors:  J D Sobel
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5.  Assessment of genetic relatedness of vaginal isolates of Candida albicans from different geographical origins.

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6.  ALLPATHS: de novo assembly of whole-genome shotgun microreads.

Authors:  Jonathan Butler; Iain MacCallum; Michael Kleber; Ilya A Shlyakhter; Matthew K Belmonte; Eric S Lander; Chad Nusbaum; David B Jaffe
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7.  The secreted aspartyl proteinases Sap1 and Sap2 cause tissue damage in an in vitro model of vaginal candidiasis based on reconstituted human vaginal epithelium.

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Review 8.  Vulvovaginal candidosis.

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9.  Genetic and phenotypic intra-species variation in Candida albicans.

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Review 2.  Microbiota in vaginal health and pathogenesis of recurrent vulvovaginal infections: a critical review.

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Review 3.  Pathogenesis and Clinical Relevance of Candida Biofilms in Vulvovaginal Candidiasis.

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Review 4.  Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health.

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