Michal Goetz1,2, Antonin Sebela3,4, Marketa Mohaplova4,5, Silvie Ceresnakova3,4, Radek Ptacek6, Tomas Novak3,7. 1. 1 Department of Paediatric Psychiatry, Motol University Hospital , Prague, Czech Republic . 2. 2 Second Faculty of Medicine, Charles University in Prague , Prague, Czech Republic . 3. 3 Clinical Center, National Institute of Mental Health , Klecany, Czech Republic . 4. 4 First Faculty of Medicine, Charles University in Prague , Prague, Czech Republic . 5. 5 Department of Psychology, Motol University Hospital , Prague, Czech Republic . 6. 6 Department of Psychiatry, General Teaching Hospital , Prague, Czech Republic . 7. 7 Third Faculty of Medicine, Charles University in Prague , Prague, Czech Republic .
Abstract
OBJECTIVE: To determine current and lifetime psychopathology and assess quality of life (QoL) in offspring of a parent with bipolar disorder (BD). METHODS: We investigated 43 offspring of bipolar parents (high-risk offspring [HRO]) (mean age 12.5 ± 3.1; range 6.7-17.9 years) and 43 comparison offspring matched for sex, age, and IQ of healthy parents. Lifetime and current presence of Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) diagnoses were assessed using Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). We administered parent and self-report versions of General Behavior Inventory and the Screen for Child Anxiety-Related Emotional Disorders (SCARED). QoL was evaluated using the self-report questionnaire KIDSCREN-52. RESULTS: Thirty-seven HRO (86%) and 18 controls (42%) met DSM-5 criteria for at least one lifetime psychiatric diagnosis (adjusted OR = 7.20; 95% CI 2.27-22.81). Compared to controls, HRO had higher lifetime frequency of any mood disorder (33% vs. 2%, p < 0.001), anxiety disorder (60% vs. 14%, p < 0.001), and attention-deficit/hyperactivity disorder (26% vs. 5%, p = 0.01). After adjustment for confounders, only mood (OR = 13.05; 95% CI 1.41-120.60) and anxiety (OR = 9.69; 95% CI 2.75-34.31) disorders remained significantly more frequent in the HRO group. In comparison with controls, HRO scored lower in the following domains: QoL, social support and relationship with peers (p = 0.003; Cohen's d = 0.91), parent relationships and home life (p = 0.008; d = 0.67), as well as self-perception (p = 0.04; d = 0.55). CONCLUSIONS: In agreement with other studies, we found a higher rate of lifetime anxiety and mood disorders in children and adolescents at confirmed familial risk for BD. Reduction in QoL was already evident across a number of domains. Adult psychiatrists should incorporate into their assessment procedures targeted questions on the presence of psychopathology in offspring of their adult patients with severe mental disorders and child services should bridge with adult services providing accessible services to children of affected parents.
OBJECTIVE: To determine current and lifetime psychopathology and assess quality of life (QoL) in offspring of a parent with bipolar disorder (BD). METHODS: We investigated 43 offspring of bipolar parents (high-risk offspring [HRO]) (mean age 12.5 ± 3.1; range 6.7-17.9 years) and 43 comparison offspring matched for sex, age, and IQ of healthy parents. Lifetime and current presence of Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-5) diagnoses were assessed using Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version (K-SADS-PL). We administered parent and self-report versions of General Behavior Inventory and the Screen for ChildAnxiety-Related Emotional Disorders (SCARED). QoL was evaluated using the self-report questionnaire KIDSCREN-52. RESULTS: Thirty-seven HRO (86%) and 18 controls (42%) met DSM-5 criteria for at least one lifetime psychiatric diagnosis (adjusted OR = 7.20; 95% CI 2.27-22.81). Compared to controls, HRO had higher lifetime frequency of any mood disorder (33% vs. 2%, p < 0.001), anxiety disorder (60% vs. 14%, p < 0.001), and attention-deficit/hyperactivity disorder (26% vs. 5%, p = 0.01). After adjustment for confounders, only mood (OR = 13.05; 95% CI 1.41-120.60) and anxiety (OR = 9.69; 95% CI 2.75-34.31) disorders remained significantly more frequent in the HRO group. In comparison with controls, HRO scored lower in the following domains: QoL, social support and relationship with peers (p = 0.003; Cohen's d = 0.91), parent relationships and home life (p = 0.008; d = 0.67), as well as self-perception (p = 0.04; d = 0.55). CONCLUSIONS: In agreement with other studies, we found a higher rate of lifetime anxiety and mood disorders in children and adolescents at confirmed familial risk for BD. Reduction in QoL was already evident across a number of domains. Adult psychiatrists should incorporate into their assessment procedures targeted questions on the presence of psychopathology in offspring of their adult patients with severe mental disorders and child services should bridge with adult services providing accessible services to children of affected parents.
Entities:
Keywords:
bipolar affective disorder; high-risk offspring; psychiatric disorders in offspring; quality of life
Authors: E De la Serna; D Ilzarbe; G Sugranyes; I Baeza; D Moreno; E Rodríguez-Toscano; A Espliego; M Ayora; S Romero; V Sánchez-Gistau; J Castro-Fornieles Journal: Eur Child Adolesc Psychiatry Date: 2020-03-07 Impact factor: 4.785
Authors: Alina Radicke; Claus Barkmann; Bonnie Adema; Anne Daubmann; Karl Wegscheider; Silke Wiegand-Grefe Journal: Int J Environ Res Public Health Date: 2021-01-06 Impact factor: 3.390
Authors: Rodrigo A Bastos; Lia S Campos; Débora B Faria-Schützer; Maíra E Brito; Diego R da Silva; Amilton Dos Santos-Junior; Egberto R Turato Journal: Braz J Psychiatry Date: 2022 Jan-Feb Impact factor: 2.697