Yuan-Hui Chen1,2, Qian Wang1,2, Ya-Nan Zhang1,2, Xiao Han1,2, Dong-Han Li1,2, Cui-Lian Zhang3,4. 1. Reproductive Medical Center, Henan Provincial People's Hospital, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. 2. Reproductive Medical Center, People's Hospital of Zhengzhou University, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. 3. Reproductive Medical Center, Henan Provincial People's Hospital, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. luckyzcl@qq.com. 4. Reproductive Medical Center, People's Hospital of Zhengzhou University, Weiwu Road, Zhengzhou, 450003, Henan Province, People's Republic of China. luckyzcl@qq.com.
Abstract
PURPOSE: This study aimed to evaluate the cumulative live birth rate (CLBR) and surplus embryo rate of polycystic ovarian syndrome (PCOS) patients during in vitro fertilization and embryo transfer (IVF-ET) treatment. METHODS: In this retrospective cohort study, we analyzed 1142 PCOS patients who underwent first IVF in our institution between January 2011 and December 2014. All patients were categorized into five groups according to the number of oocytes retrieved. Main outcomes include CLBR and surplus embryo rate. RESULTS: A strong correlation was observed between number of oocytes retrieved and CLBR as well as surplus embryo rate in PCOS patients. CLBR was elevated with the increasing number of oocytes and plateaued when oocyte number was up to ten, whereas the surplus embryo rate steadily increased in line with the increase of oocyte number. Patients transferred with frozen embryos showed higher CLBR and LBR during first ET than patients transferred with fresh embryos. CONCLUSIONS: For PCOS patients, retrieving more than ten oocytes leads to no significant benefit to CLBR but generates surplus embryos. Thus, moderate ovarian stimulation should be reconsidered during IVF treatment.
PURPOSE: This study aimed to evaluate the cumulative live birth rate (CLBR) and surplus embryo rate of polycystic ovarian syndrome (PCOS) patients during in vitro fertilization and embryo transfer (IVF-ET) treatment. METHODS: In this retrospective cohort study, we analyzed 1142 PCOSpatients who underwent first IVF in our institution between January 2011 and December 2014. All patients were categorized into five groups according to the number of oocytes retrieved. Main outcomes include CLBR and surplus embryo rate. RESULTS: A strong correlation was observed between number of oocytes retrieved and CLBR as well as surplus embryo rate in PCOSpatients. CLBR was elevated with the increasing number of oocytes and plateaued when oocyte number was up to ten, whereas the surplus embryo rate steadily increased in line with the increase of oocyte number. Patients transferred with frozen embryos showed higher CLBR and LBR during first ET than patients transferred with fresh embryos. CONCLUSIONS: For PCOSpatients, retrieving more than ten oocytes leads to no significant benefit to CLBR but generates surplus embryos. Thus, moderate ovarian stimulation should be reconsidered during IVF treatment.
Authors: Esther Mew Heijnen; Marinus Jc Eijkemans; Cora De Klerk; Suzanne Polinder; Nicole Gm Beckers; Ellen R Klinkert; Frank J Broekmans; Jan Passchier; Egbert R Te Velde; Nick S Macklon; Bart Cjm Fauser Journal: Lancet Date: 2007-03-03 Impact factor: 79.321
Authors: Esther B Baart; Elena Martini; Marinus J Eijkemans; Diane Van Opstal; Nicole G M Beckers; Arie Verhoeff; Nicolas S Macklon; Bart C J M Fauser Journal: Hum Reprod Date: 2007-01-04 Impact factor: 6.918
Authors: Jennifer Blum; Tara Shochet; Kelsey Lynd; E Steve Lichtenberg; Dick Fischer; Michelle Arnesen; Beverly Winikoff; Paul D Blumenthal Journal: Contraception Date: 2012-08-13 Impact factor: 3.375