| Literature DB >> 2857792 |
N P Peet, L E Baugh, S Sunder, J E Lewis.
Abstract
A group of 1,4-dihydro-4-oxoquinoline-2- and -3-carboxylic acid esters with nitrogen functionality at the 8-position was synthesized, and 6-oxo-6H-imidazo[4,5,1-ij]quinoline-4- and -5-carboxylic acid esters were elaborated from these. Several of the compounds displayed activity in the rat passive cutaneous anaphylaxis (PCA) test for antiallergic activity. However, PCA activity in this series was accompanied by rat toxicity, as measured by a decrease in percent of normal weight gain over a 2-week period, following a single oral dose.Entities:
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Year: 1985 PMID： 2857792 DOI： 10.1021/jm00381a007
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446