Literature DB >> 23579860

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide.

Sunil Kumar1, Andrew D Miranker.   

Abstract

A small molecule, protein mimetic based approach is shown to specifically inhibit lipid catalysed self-assembly of islet amyloid polypeptide (IAPP). The lipid-bound oligomerization of this peptide is implicated in cellular dysfunction of insulin secreting β-cells in type II diabetes.

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Year:  2013        PMID： 23579860      PMCID： PMC3968531          DOI： 10.1039/c3cc41452c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  23 in total

1.  Inhibition of islet amyloid polypeptide fibril formation: a potential role for heteroaromatic interactions.

Authors:  Yair Porat; Yariv Mazor; Shimon Efrat; Ehud Gazit
Journal:  Biochemistry       Date:  2004-11-16       Impact factor: 3.162

Review 2.  Protein misfolding, functional amyloid, and human disease.

Authors:  Fabrizio Chiti; Christopher M Dobson
Journal:  Annu Rev Biochem       Date:  2006       Impact factor: 23.643

3.  Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol.

Authors:  Rajesh Mishra; Daniel Sellin; Diana Radovan; Andrea Gohlke; Roland Winter
Journal:  Chembiochem       Date:  2009-02-13       Impact factor: 3.164

4.  Small-molecule inhibitors of islet amyloid polypeptide fibril formation.

Authors:  Rajesh Mishra; Bruno Bulic; Daniel Sellin; Suman Jha; Herbert Waldmann; Roland Winter
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

5.  Aromatic delta-peptides.

Authors:  Hua Jiang; Jean-Michel Léger; Ivan Huc
Journal:  J Am Chem Soc       Date:  2003-03-26       Impact factor: 15.419

6.  Phenolsulfonphthalein, but not phenolphthalein, inhibits amyloid fibril formation: implications for the modulation of amyloid self-assembly.

Authors:  Michal Levy; Yair Porat; Eran Bacharach; Deborah E Shalev; Ehud Gazit
Journal:  Biochemistry       Date:  2008-05-06       Impact factor: 3.162

7.  The polyphenol EGCG inhibits amyloid formation less efficiently at phospholipid interfaces than in bulk solution.

Authors:  Maarten F M Engel; Corianne C vandenAkker; Michael Schleeger; Krassimir P Velikov; Gijsje H Koenderink; Mischa Bonn
Journal:  J Am Chem Soc       Date:  2012-08-27       Impact factor: 15.419

8.  Structure of alpha-helical membrane-bound human islet amyloid polypeptide and its implications for membrane-mediated misfolding.

Authors:  Melania Apostolidou; Sajith A Jayasinghe; Ralf Langen
Journal:  J Biol Chem       Date:  2008-04-28       Impact factor: 5.157

9.  Design of a mimic of nonamyloidogenic and bioactive human islet amyloid polypeptide (IAPP) as nanomolar affinity inhibitor of IAPP cytotoxic fibrillogenesis.

Authors:  Li-Mei Yan; Marianna Tatarek-Nossol; Aleksandra Velkova; Athanasios Kazantzis; Aphrodite Kapurniotu
Journal:  Proc Natl Acad Sci U S A       Date:  2006-02-07       Impact factor: 11.205

Review 10.  Adapting proteostasis for disease intervention.

Authors:  William E Balch; Richard I Morimoto; Andrew Dillin; Jeffery W Kelly
Journal:  Science       Date:  2008-02-15       Impact factor: 63.714
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  15 in total

1.  Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β.

Authors:  Kyle J Korshavn; Cristina Satriano; Yuxi Lin; Rongchun Zhang; Mark Dulchavsky; Anirban Bhunia; Magdalena I Ivanova; Young-Ho Lee; Carmelo La Rosa; Mi Hee Lim; Ayyalusamy Ramamoorthy
Journal:  J Biol Chem       Date:  2017-02-01       Impact factor: 5.157

2.  Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity.

Authors:  Abhinav Nath; Diana E Schlamadinger; Elizabeth Rhoades; Andrew D Miranker
Journal:  Biochemistry       Date:  2015-05-22       Impact factor: 3.162

3.  Metastable intermediate during hIAPP aggregation catalyzed by membranes as detected with 2D IR spectroscopy.

Authors:  Sidney S Dicke; Michał Maj; Caitlyn R Fields; Martin T Zanni
Journal:  RSC Chem Biol       Date:  2022-06-13

4.  Folded small molecule manipulation of islet amyloid polypeptide.

Authors:  Sunil Kumar; Mark A Brown; Abhinav Nath; Andrew D Miranker
Journal:  Chem Biol       Date:  2014-06-12

5.  The Rational Discovery of a Tau Aggregation Inhibitor.

Authors:  David W Baggett; Abhinav Nath
Journal:  Biochemistry       Date:  2018-10-05       Impact factor: 3.162

6.  Foldamer scaffolds suggest distinct structures are associated with alternative gains-of-function in a preamyloid toxin.

Authors:  Sunil Kumar; Melissa Birol; Andrew D Miranker
Journal:  Chem Commun (Camb)       Date:  2016-04-15       Impact factor: 6.222

7.  Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.

Authors:  Amit S Pithadia; Anirban Bhunia; Rajendran Sribalan; Vediappen Padmini; Carol A Fierke; Ayyalusamy Ramamoorthy
Journal:  Chem Commun (Camb)       Date:  2016-01-18       Impact factor: 6.222

8.  Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly.

Authors:  Jemil Ahmed; Tessa C Fitch; Courtney M Donnelly; Johnson A Joseph; Tyler D Ball; Mikaela M Bassil; Ahyun Son; Chen Zhang; Aurélie Ledreux; Scott Horowitz; Yan Qin; Daniel Paredes; Sunil Kumar
Journal:  Nat Commun       Date:  2022-04-27       Impact factor: 17.694

9.  Peptide-lipid interactions: experiments and applications.

Authors:  Stefania Galdiero; Annarita Falanga; Marco Cantisani; Mariateresa Vitiello; Giancarlo Morelli; Massimiliano Galdiero
Journal:  Int J Mol Sci       Date:  2013-09-12       Impact factor: 5.923

10.  Ion mobility spectrometry-mass spectrometry defines the oligomeric intermediates in amylin amyloid formation and the mode of action of inhibitors.

Authors:  Lydia M Young; Ping Cao; Daniel P Raleigh; Alison E Ashcroft; Sheena E Radford
Journal:  J Am Chem Soc       Date:  2013-12-30       Impact factor: 15.419
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