Qing Zhang1, Shaozheng Liu1, Yanxing Guan1, Qingjie Chen1, Qing Zhang1, Xiang Min2. 1. Department of Nuclear Medicine, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. 2. Department of Otolaryngology & Head and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Abstract
OBJECTIVES: This study was designed to unveil the association of GPR174 rs3827440, PTPN22 rs3789604, and RNASET2 rs9355610 with the onset of liver damage (LD) among the Graves' disease (GD) patients. METHODS: A total of 120 GD patients were divided into the none-LD and LD groups. Several indicators were detected for assessing liver functions, and genotypes of single nucleotide polymorphisms (SNPs) were identified. Logistic regression was introduced for investigating the relationship between risk SNPs and LD-associated hyperthyroidism in GD patients. RESULTS: Significant differences were identified between LD and none-LD groups regarding genotype distributions of rs3827440, rs3789604, and rs9355610. Results from logistic regression indicted that among the GD patients, C carriers of PTPN22 rs3789604 were associated with a higher risk of LD-associated hyperthyroidism, while C carriers of rs3827440 (GPR174) and G carriers of rs9355610 (RNASET2) were associated with a reduced risk of LD-associated hyperthyroidism. CONCLUSIONS: The C allele of rs3789604 (PTPN22) was a significant risk factor for LD-associated hyperthyroidism in GD patients, whereas C allele of GPR174 rs3827440 and G allele of RNASET2 rs9355610 appeared to be a protective factor for this disease.
OBJECTIVES: This study was designed to unveil the association of GPR174rs3827440, PTPN22rs3789604, and RNASET2rs9355610 with the onset of liver damage (LD) among the Graves' disease (GD) patients. METHODS: A total of 120 GDpatients were divided into the none-LD and LD groups. Several indicators were detected for assessing liver functions, and genotypes of single nucleotide polymorphisms (SNPs) were identified. Logistic regression was introduced for investigating the relationship between risk SNPs and LD-associated hyperthyroidism in GDpatients. RESULTS: Significant differences were identified between LD and none-LD groups regarding genotype distributions of rs3827440, rs3789604, and rs9355610. Results from logistic regression indicted that among the GDpatients, C carriers of PTPN22rs3789604 were associated with a higher risk of LD-associated hyperthyroidism, while C carriers of rs3827440 (GPR174) and G carriers of rs9355610 (RNASET2) were associated with a reduced risk of LD-associated hyperthyroidism. CONCLUSIONS: The C allele of rs3789604 (PTPN22) was a significant risk factor for LD-associated hyperthyroidism in GDpatients, whereas C allele of GPR174rs3827440 and G allele of RNASET2rs9355610 appeared to be a protective factor for this disease.
Authors: Ashok Sharma; Xiang Liu; David Hadley; William Hagopian; Wei-Min Chen; Suna Onengut-Gumuscu; Carina Törn; Andrea K Steck; Brigitte I Frohnert; Marian Rewers; Anette-G Ziegler; Åke Lernmark; Jorma Toppari; Jeffrey P Krischer; Beena Akolkar; Stephen S Rich; Jin-Xiong She Journal: J Autoimmun Date: 2018-01-05 Impact factor: 14.511