Dennis Anheyer1, Jane Frawley2, Anna Katharina Koch3,4, Romy Lauche3,2, Jost Langhorst3,4, Gustav Dobos3, Holger Cramer3,2. 1. Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, and d.anheyer@kliniken-essen-mitte.de. 2. Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), University of Technology Sydney, Sydney, Australia. 3. Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, and. 4. Department of Integrative Gastroenterology, University of Duisburg-Essen, Essen, Germany; and.
Abstract
CONTEXT: Gastrointestinal disorders are common childhood complaints. Particular types of complementary and alternative medicine, such as herbal medicine, are commonly used among children. Research information on efficacy, safety, or dosage forms is still lacking. OBJECTIVES: To systematically summarize effectiveness and safety of different herbal treatment options for gastrointestinal disorders in children. DATA SOURCES: Medline/PubMed, Scopus, and the Cochrane Library were searched through July 15, 2016. STUDY SELECTION: Randomized controlled trials comparing herbal therapy with no treatment, placebo, or any pharmaceutical medication in children and adolescents (aged 0-18 years) with gastrointestinal disorders were eligible. DATA EXTRACTION: Two authors extracted data on study design, patients, interventions, control interventions, results, adverse events, and risk of bias. RESULTS: Fourteen trials with 1927 participants suffering from different acute and functional gastrointestinal disorders were included in this review. Promising evidence for effectiveness was found for Potentilla erecta, carob bean juice, and an herbal compound preparation including Matricaria chamomilla in treating diarrhea. Moreover, evidence was found for peppermint oil in decreasing duration, frequency, and severity of pain in children suffering from undifferentiated functional abdominal pain. Furthermore, evidence for effectiveness was found for different fennel preparations (eg, oil, tea, herbal compound) in treating children with infantile colic. No serious adverse events were reported. LIMITATIONS: Few studies on specific indications, single herbs, or herbal preparations could be identified. CONCLUSIONS: Because of the limited number of studies, results have to be interpreted carefully. To underpin evidence outlined in this review, more rigorous clinical trials are needed.
CONTEXT: Gastrointestinal disorders are common childhood complaints. Particular types of complementary and alternative medicine, such as herbal medicine, are commonly used among children. Research information on efficacy, safety, or dosage forms is still lacking. OBJECTIVES: To systematically summarize effectiveness and safety of different herbal treatment options for gastrointestinal disorders in children. DATA SOURCES: Medline/PubMed, Scopus, and the Cochrane Library were searched through July 15, 2016. STUDY SELECTION: Randomized controlled trials comparing herbal therapy with no treatment, placebo, or any pharmaceutical medication in children and adolescents (aged 0-18 years) with gastrointestinal disorders were eligible. DATA EXTRACTION: Two authors extracted data on study design, patients, interventions, control interventions, results, adverse events, and risk of bias. RESULTS: Fourteen trials with 1927 participants suffering from different acute and functional gastrointestinal disorders were included in this review. Promising evidence for effectiveness was found for Potentilla erecta, carob bean juice, and an herbal compound preparation including Matricaria chamomilla in treating diarrhea. Moreover, evidence was found for peppermintoil in decreasing duration, frequency, and severity of pain in children suffering from undifferentiated functional abdominal pain. Furthermore, evidence for effectiveness was found for different fennel preparations (eg, oil, tea, herbal compound) in treating children with infantile colic. No serious adverse events were reported. LIMITATIONS: Few studies on specific indications, single herbs, or herbal preparations could be identified. CONCLUSIONS: Because of the limited number of studies, results have to be interpreted carefully. To underpin evidence outlined in this review, more rigorous clinical trials are needed.
Authors: Tu Mai; Nicole Y Fatheree; Wallace Gleason; Yuying Liu; Jon Marc Rhoads Journal: Gastroenterol Clin North Am Date: 2018-09-28 Impact factor: 3.806
Authors: Abdur Rauf; Muhammad Akram; Prabhakar Semwal; Adil A H Mujawah; Naveed Muhammad; Zerfishan Riaz; Naveed Munir; Dmitry Piotrovsky; Irina Vdovina; Abdelhakim Bouyahya; Charles Oluwaseun Adetunji; Mohammad Ali Shariati; Zainab M Almarhoon; Yahia N Mabkhot; Haroon Khan Journal: Oxid Med Cell Longev Date: 2021-11-11 Impact factor: 6.543