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Literature DB >> 28561053

Mitochondria link metabolism and epigenetics in haematopoiesis.

Abstract

Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

Mesh：

Year: 2017 PMID： 28561053 DOI： 10.1038/ncb3540

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

14 in total

1. TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions.

Authors: Inmaculada Martínez-Reyes; Lauren P Diebold; Hyewon Kong; Michael Schieber; He Huang; Christopher T Hensley; Manan M Mehta; Tianyuan Wang; Janine H Santos; Richard Woychik; Eric Dufour; Johannes N Spelbrink; Samuel E Weinberg; Yingming Zhao; Ralph J DeBerardinis; Navdeep S Chandel
Journal: Mol Cell Date: 2015-12-24 Impact factor: 17.970

2. Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Authors: Andrew R Mullen; Zeping Hu; Xiaolei Shi; Lei Jiang; Lindsey K Boroughs; Zoltan Kovacs; Richard Boriack; Dinesh Rakheja; Lucas B Sullivan; W Marston Linehan; Navdeep S Chandel; Ralph J DeBerardinis
Journal: Cell Rep Date: 2014-05-22 Impact factor: 9.423

Review 3. Metabolic requirements for the maintenance of self-renewing stem cells.

Authors: Keisuke Ito; Toshio Suda
Journal: Nat Rev Mol Cell Biol Date: 2014-04 Impact factor: 94.444

Review 4. Evolution of Mitochondria as Signaling Organelles.

Authors: Navdeep S Chandel
Journal: Cell Metab Date: 2015-06-11 Impact factor: 27.287

5. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.

Authors: Kıvanç Birsoy; Tim Wang; Walter W Chen; Elizaveta Freinkman; Monther Abu-Remaileh; David M Sabatini
Journal: Cell Date: 2015-07-30 Impact factor: 41.582

6. Purification and characterization of mouse hematopoietic stem cells.

Authors: G J Spangrude; S Heimfeld; I L Weissman
Journal: Science Date: 1988-07-01 Impact factor: 47.728

7. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases.

Authors: Wei Xu; Hui Yang; Ying Liu; Ying Yang; Ping Wang; Se-Hee Kim; Shinsuke Ito; Chen Yang; Pu Wang; Meng-Tao Xiao; Li-xia Liu; Wen-qing Jiang; Jing Liu; Jin-ye Zhang; Bin Wang; Stephen Frye; Yi Zhang; Yan-hui Xu; Qun-ying Lei; Kun-Liang Guan; Shi-min Zhao; Yue Xiong
Journal: Cancer Cell Date: 2011-01-18 Impact factor: 38.585

8. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Authors: Maria E Figueroa; Omar Abdel-Wahab; Chao Lu; Patrick S Ward; Jay Patel; Alan Shih; Yushan Li; Neha Bhagwat; Aparna Vasanthakumar; Hugo F Fernandez; Martin S Tallman; Zhuoxin Sun; Kristy Wolniak; Justine K Peeters; Wei Liu; Sung E Choe; Valeria R Fantin; Elisabeth Paietta; Bob Löwenberg; Jonathan D Licht; Lucy A Godley; Ruud Delwel; Peter J M Valk; Craig B Thompson; Ross L Levine; Ari Melnick
Journal: Cancer Cell Date: 2010-12-09 Impact factor: 38.585

9. Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors.

Authors: Mengtao Xiao; Hui Yang; Wei Xu; Shenghong Ma; Huaipeng Lin; Honguang Zhu; Lixia Liu; Ying Liu; Chen Yang; Yanhui Xu; Shimin Zhao; Dan Ye; Yue Xiong; Kun-Liang Guan
Journal: Genes Dev Date: 2012-06-07 Impact factor: 12.890

10. Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation.

Authors: Xin Liu; Yuannyu Zhang; Min Ni; Hui Cao; Robert A J Signer; Dan Li; Mushan Li; Zhimin Gu; Zeping Hu; Kathryn E Dickerson; Samuel E Weinberg; Navdeep S Chandel; Ralph J DeBerardinis; Feng Zhou; Zhen Shao; Jian Xu
Journal: Nat Cell Biol Date: 2017-05-15 Impact factor: 28.824

7 in total

1. Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

Authors: Nai-Jia Huang; Ying-Cing Lin; Chung-Yueh Lin; Novalia Pishesha; Caroline A Lewis; Elizaveta Freinkman; Colin Farquharson; José Luis Millán; Harvey Lodish
Journal: Blood Date: 2018-04-30 Impact factor: 22.113

2. Closing the Mitochondrial Permeability Transition Pore in hiPSC-Derived Endothelial Cells Induces Glycocalyx Formation and Functional Maturation.

Authors: Gesa L Tiemeier; Gangqi Wang; Sébastien J Dumas; Wendy M P J Sol; M Cristina Avramut; Tobias Karakach; Valeria V Orlova; Cathelijne W van den Berg; Christine L Mummery; Peter Carmeliet; Bernard M van den Berg; Ton J Rabelink
Journal: Stem Cell Reports Date: 2019-10-31 Impact factor: 7.765

3. Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics.

Authors: Alvaro M Gonzalez-Ibanez; Lina M Ruiz; Erik Jensen; Cesar A Echeverria; Valentina Romero; Linsey Stiles; Orian S Shirihai; Alvaro A Elorza
Journal: Front Cell Dev Biol Date: 2020-11-23

4. Transmission Electron Microscopy to Follow Ultrastructural Modifications of Erythroblasts Upon ex vivo Human Erythropoiesis.

Authors: Alice Dussouchaud; Julieta Jacob; Charles Secq; Jean-Marc Verbavatz; Martina Moras; Jérôme Larghero; Claudio M Fader; Mariano A Ostuni; Sophie D Lefevre
Journal: Front Physiol Date: 2022-02-09 Impact factor: 4.566