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Literature DB >> 2898810

Purification and characterization of mouse hematopoietic stem cells.

G J Spangrude¹, S Heimfeld, I L Weissman.

Abstract

Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.

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Year: 1988 PMID： 2898810 DOI： 10.1126/science.2898810

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

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Cited

683 in total

1. Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.

Authors: S K Cho; T D Webber; J R Carlyle; T Nakano; S M Lewis; J C Zúñiga-Pflücker
Journal: Proc Natl Acad Sci U S A Date: 1999-08-17 Impact factor: 11.205

2. The power of stem cells reconsidered?

Authors: I Lemischka
Journal: Proc Natl Acad Sci U S A Date: 1999-12-07 Impact factor: 11.205

3. Direct isolation of human central nervous system stem cells.

Authors: N Uchida; D W Buck; D He; M J Reitsma; M Masek; T V Phan; A S Tsukamoto; F H Gage; I L Weissman
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

4. Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates.

Authors: D S Stoner; B Rinkevich; I L Weissman
Journal: Proc Natl Acad Sci U S A Date: 1999-08-03 Impact factor: 11.205

5. Characterization and distribution of a new cell surface marker of neuronal precursors.

Authors: W Schubert; V Coskun; M Tahmina; M S Rao; M B Luskin; Z Kaprielian
Journal: Dev Neurosci Date: 2000 Impact factor: 2.984

6. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection.

Authors: J A Shizuru; I L Weissman; R Kernoff; M Masek; Y C Scheffold
Journal: Proc Natl Acad Sci U S A Date: 2000-08-15 Impact factor: 11.205

Purification and characterization of mouse hematopoietic stem cells.

1. Functional characterization of B lymphocytes generated in vitro from embryonic stem cells.

2. The power of stem cells reconsidered?

3. Direct isolation of human central nervous system stem cells.

4. Heritable germ and somatic cell lineage competitions in chimeric colonial protochordates.

5. Characterization and distribution of a new cell surface marker of neuronal precursors.

6. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection.

7. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs.

8. Clonable progenitors committed to the T lymphocyte lineage in the mouse bone marrow; use of an extrathymic pathway.

9. Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease?

10. Localization of CD44 and CD90 positive cells to the invasive front of breast tumors.