Literature DB >> 28560066

GalNAc-T6 in the relationship with invasion ability of endometrial carcinomas and prognostic significance.

Thuy Thi Nguyen1, Tomoko Kurita1, Chiho Koi1, Midori Murakami1, Seiji Kagami1, Toru Hachisuga1, Hisaoka Masanori2, Yasuo Morimoto3, Hiroto Izumi3.   

Abstract

O-glycosylation in the field of carcinogenesis has been a critical topic of concern for several decades. The abnormal function of enzymes catalyzing the first step of this process, named polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts) has been determined to play an important role in cancer development and metastasis. Accordingly, we investigated the expression of GalNAc-T6 in endometrial carcinoma and evaluated the relationship between invasion characteristics and the cellular level of GalNAc-T6. The results suggested that positive GalNAc-T6 expression is significantly associated with histological grade of tumors and myometrial invasion characteristic. In vitro experiments showed that the over expression of GalNAc-T6 had strong association with the decrease of endometrial cell invasiveness. Taken together, our data support the use of GalNAc-T6 as a potential indicator of good prognosis and noninvasive tumor in patients with endometrial carcinoma.

Entities:  

Keywords:  O-glycosylation; cell invasion; cell migration; endometrial carcinoma; polypeptide N-acetylgalactosaminyltransferase 6

Year:  2017        PMID： 28560066      PMCID： PMC5446483     

Source DB:  PubMed          Journal:  Am J Cancer Res        ISSN： 2156-6976            Impact factor:   6.166


  24 in total

Review 1.  The biology of cell locomotion within three-dimensional extracellular matrix.

Authors:  P Friedl; E B Bröcker
Journal:  Cell Mol Life Sci       Date:  2000-01-20       Impact factor: 9.261

2.  A family of UDP-GalNAc: polypeptide N-acetylgalactosaminyl-transferases control the initiation of mucin-type O-linked glycosylation.

Authors:  H Clausen; E P Bennett
Journal:  Glycobiology       Date:  1996-09       Impact factor: 4.313

3.  Substrate specificities of three members of the human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3.

Authors:  H H Wandall; H Hassan; E Mirgorodskaya; A K Kristensen; P Roepstorff; E P Bennett; P A Nielsen; M A Hollingsworth; J Burchell; J Taylor-Papadimitriou; H Clausen
Journal:  J Biol Chem       Date:  1997-09-19       Impact factor: 5.157

4.  UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker.

Authors:  Nora Berois; Daniel Mazal; Luis Ubillos; Felipe Trajtenberg; André Nicolas; Xavier Sastre-Garau; Henri Magdelenat; Eduardo Osinaga
Journal:  J Histochem Cytochem       Date:  2005-10-31       Impact factor: 2.479

5.  Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy.

Authors:  E P Bennett; H Hassan; U Mandel; M A Hollingsworth; N Akisawa; Y Ikematsu; G Merkx; A G van Kessel; S Olofsson; H Clausen
Journal:  J Biol Chem       Date:  1999-09-03       Impact factor: 5.157

Review 6.  The sweet and sour of cancer: glycans as novel therapeutic targets.

Authors:  Mark M Fuster; Jeffrey D Esko
Journal:  Nat Rev Cancer       Date:  2005-07       Impact factor: 60.716

Review 7.  Tumour-cell invasion and migration: diversity and escape mechanisms.

Authors:  Peter Friedl; Katarina Wolf
Journal:  Nat Rev Cancer       Date:  2003-05       Impact factor: 60.716

Review 8.  Cell migration.

Authors:  Xavier Trepat; Zaozao Chen; Ken Jacobson
Journal:  Compr Physiol       Date:  2012-10       Impact factor: 9.090

9.  Polypeptide N-acetylgalactosaminyl transferase 3 independently predicts high-grade tumours and poor prognosis in patients with renal cell carcinomas.

Authors:  S Kitada; S Yamada; A Kuma; S Ouchi; T Tasaki; A Nabeshima; H Noguchi; K-Y Wang; S Shimajiri; R Nakano; H Izumi; K Kohno; T Matsumoto; Y Sasaguri
Journal:  Br J Cancer       Date:  2013-06-25       Impact factor: 7.640

10.  Strong expression of polypeptide N-acetylgalactosaminyltransferase 3 independently predicts shortened disease-free survival in patients with early stage oral squamous cell carcinoma.

Authors:  Yoshikazu Harada; Hiroto Izumi; Hirotsugu Noguchi; Akihiro Kuma; Yuichiro Kawatsu; Tomoko Kimura; Shohei Kitada; Hidetaka Uramoto; Ke-Yong Wang; Yasuyuki Sasaguri; Hiroshi Hijioka; Akihiko Miyawaki; Ryoichi Oya; Toshiyuki Nakayama; Kimitoshi Kohno; Sohsuke Yamada
Journal:  Tumour Biol       Date:  2015-08-22
View more
  6 in total

1.  The vaginal microbiome is associated with endometrial cancer grade and histology.

Authors:  Hesamedin Hakimjavadi; Sophia H George; Michael Taub; Leah V Dodds; Alex P Sanchez-Covarrubias; Marilyn Huang; J Matt Pearson; Brian M Slomovitz; Erin N Kobetz; Raad Gharaibeh; Ramlogan Sowamber; Andre Pinto; Srikar Chamala; Matthew P Schlumbrecht
Journal:  Cancer Res Commun       Date:  2022-06-16

2.  Bisimidazolium Salt Glycosyltransferase Inhibitors Suppress Hepatocellular Carcinoma Progression In Vitro and In Vivo.

Authors:  Xue Luan; Ming Sun; Xue Zhao; Jingyi Wang; Ye Han; Yin Gao
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-05

3.  Early-Stage Loss of GALNT6 Predicts Poor Clinical Outcome in Colorectal Cancer.

Authors:  Makiko Ogawa; Atsushi Tanaka; Kei Namba; Jinru Shia; Julia Y Wang; Michael H Roehrl
Journal:  Front Oncol       Date:  2022-05-27       Impact factor: 5.738

4.  The polypeptide GALNT6 Displays Redundant Functions upon Suppression of its Closest Homolog GALNT3 in Mediating Aberrant O-Glycosylation, Associated with Ovarian Cancer Progression.

Authors:  Razan Sheta; Magdalena Bachvarova; Elizabeth Macdonald; Stephane Gobeil; Barbara Vanderhyden; Dimcho Bachvarov
Journal:  Int J Mol Sci       Date:  2019-05-08       Impact factor: 5.923

5.  A Novel Glycosyltransferase-Related Gene Signature for Overall Survival Prediction in Patients with Ovarian Cancer.

Authors:  Liang Wang
Journal:  Int J Gen Med       Date:  2021-12-25

Review 6.  Glycosylation and its research progress in endometrial cancer.

Authors:  Congli Pu; Kai Xu; Yingchao Zhao
Journal:  Clin Transl Oncol       Date:  2022-06-25       Impact factor: 3.340
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.