Saad Elzanaty1, Babak Rezanezhad2, Gert Dohle3. 1. Department of Translational Medicine, Division of Urological Research, Skåne University Hospital, Lund University, Malmö, Skåne University Hospital, Lund, Sweden. 2. Department of Internal Medicine, Skåne University Hospital, Lund, Sweden. 3. Department of Urology, Erasmus University Medical Centre, Rotterdam, Skåne University Hospital, Lund, Sweden.
Abstract
INTRODUCTION: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. MATERIALS AND METHODS: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone > 12 nmol/l). RESULTS: The mean age of the subjects was 55 years (range 46-60 years). No significant correlation between serum testosterone and PSA levels was found (p = 0.60). PSA levels were similar when compared between hypogonadal and eugonadal men (1.4 µg/l vs. 1.4 µg/l, p = 0.90). When using a multivariate analysis model adjusted for the age of the subjects, BMI, waist-to-hip ratio, smoking, and alcohol consumption, a positive significant association between testosterone and PSA levels was found (β = 0.03, 95 % CI = 0.003-0.062, p = 0.03). CONCLUSION: Only after adjusted multivariate analysis, our results indicated that testosterone was associated with PSA levels in middle-aged healthy men.
INTRODUCTION: The aim of the present study was to evaluate the association between serum testosterone and PSA levels in middle-aged healthy men from the general population. MATERIALS AND METHODS: Based on 119 healthy men from the general population, total testosterone and PSA levels were measured. Demographic data regarding BMI, waist-to-hip ratio, smoking, and alcohol consumption were also collected. Men were classified into two groups according to testosterone levels; hypogonadal (testosterone ≤ 12 nmol/l), and eugonadal (testosterone > 12 nmol/l). RESULTS: The mean age of the subjects was 55 years (range 46-60 years). No significant correlation between serum testosterone and PSA levels was found (p = 0.60). PSA levels were similar when compared between hypogonadal and eugonadalmen (1.4 µg/l vs. 1.4 µg/l, p = 0.90). When using a multivariate analysis model adjusted for the age of the subjects, BMI, waist-to-hip ratio, smoking, and alcohol consumption, a positive significant association between testosterone and PSA levels was found (β = 0.03, 95 % CI = 0.003-0.062, p = 0.03). CONCLUSION: Only after adjusted multivariate analysis, our results indicated that testosterone was associated with PSA levels in middle-aged healthy men.
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