Literature DB >> 28558293

Blood-brain barrier peptide shuttles.

Macarena Sánchez-Navarro1, Ernest Giralt2, Meritxell Teixidó3.   

Abstract

Brain delivery is hampered by the presence of the blood-brain barrier (BBB), a natural defence of the brain that protects it and allows the entrance of nutrients by several mechanisms. Taking advantage of these mechanisms is an opportunity to treat brain related diseases. Among the different alternatives, BBB peptide shuttles are gaining attention to increase brain delivery of therapeutics. The most recent advances in the field are analysed here.
Copyright © 2017 Elsevier Ltd. All rights reserved.

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Year:  2017        PMID： 28558293     DOI： 10.1016/j.cbpa.2017.04.019

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


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