Klaus Christian Mende1, Jakob Matschke2, Till Burkhardt1, Wolfgang Saeger2, Rolf Buslei3, Michael Buchfelder4, Rudolf Fahlbusch5, Manfred Westphal1, Jörg Flitsch1. 1. Department of Neurosurgery, Hamburg University Medical Center, Hamburg, Germany. 2. Institute of Neuropathology, Hamburg University Medical Center, Hamburg, Germany. 3. Department of Neuropathology, University of Erlangen, Erlangen, Germany. 4. Department of Neurosurgery, University of Erlangen, Erlangen, Germany. 5. International Neuroscience Institute Hannover GmbH, Hannover, Germany.
Abstract
INTRODUCTION: Pituicytoma is a rare neoplasm of the sella region. Tumor resection is the primary treatment option, but remains subtotal due to excessive bleeding in many cases. The search for alternative or additional treatment regimens is necessary. AIMS: We aimed to determine the receptor expression of pituicytoma to find alternatives or supplements to surgical therapy in the use of targeted therapies. METHODS: Pituicytoma samples were collected from three institutions between 2006 and 2015 and were stained for vascular endothelial growth factors (VEGF), thyroid transcription factor (TTF1), and somatostatin receptors (SSTR 2/3/5). The stains were classified from 0=no staining to +++=strong staining. A complementary retrospective analysis of the patient charts regarding sex, age, and primary symptoms, pituitary function, and perioperative complications was performed. RESULTS: Ten samples were analyzed; mean patient age was 57.8 years SD 16.3 years. Seven samples were acquired from male patients (one relapse) and three from female. All tumors stained strongly positive (+++) for VEGF-R. Six samples stained positive for TTF1. As for somatostatin receptors, three samples were slightly positive for SSTR 2; seven were negative. SSTR 3 was + in one, three were ++, three were +++, and three were 0. SSTR 5 stained +++ in 1, ++ in 5, + in 1, and 0 in three patients. CONCLUSIONS: Pituicytomas were generally positive for VEGFR and showed regular expression of SSTR 3 and 5 indicating a possible treatment option through targeted therapies in cases where resection remains insufficient. Further research is necessary as to whether tumor growth can be inhibited using these pathways.
INTRODUCTION: Pituicytoma is a rare neoplasm of the sella region. Tumor resection is the primary treatment option, but remains subtotal due to excessive bleeding in many cases. The search for alternative or additional treatment regimens is necessary. AIMS: We aimed to determine the receptor expression of pituicytoma to find alternatives or supplements to surgical therapy in the use of targeted therapies. METHODS: Pituicytoma samples were collected from three institutions between 2006 and 2015 and were stained for vascular endothelial growth factors (VEGF), thyroid transcription factor (TTF1), and somatostatin receptors (SSTR 2/3/5). The stains were classified from 0=no staining to +++=strong staining. A complementary retrospective analysis of the patient charts regarding sex, age, and primary symptoms, pituitary function, and perioperative complications was performed. RESULTS: Ten samples were analyzed; mean patient age was 57.8 years SD 16.3 years. Seven samples were acquired from male patients (one relapse) and three from female. All tumors stained strongly positive (+++) for VEGF-R. Six samples stained positive for TTF1. As for somatostatin receptors, three samples were slightly positive for SSTR 2; seven were negative. SSTR 3 was + in one, three were ++, three were +++, and three were 0. SSTR 5 stained +++ in 1, ++ in 5, + in 1, and 0 in three patients. CONCLUSIONS: Pituicytomas were generally positive for VEGFR and showed regular expression of SSTR 3 and 5 indicating a possible treatment option through targeted therapies in cases where resection remains insufficient. Further research is necessary as to whether tumor growth can be inhibited using these pathways.
Authors: A Merlo; O Hausmann; M Wasner; P Steiner; A Otte; E Jermann; P Freitag; J C Reubi; J Müller-Brand; O Gratzl; H R Mäcke Journal: Clin Cancer Res Date: 1999-05 Impact factor: 12.531
Authors: Klaus Christian Mende; Jakob Matschke; Till Burkhardt; Wolfgang Saeger; Rolf Buslei; Michael Buchfelder; Rudolf Fahlbusch; Manfred Westphal; Jörg Flitsch Journal: CNS Neurosci Ther Date: 2017-05-28 Impact factor: 5.243
Authors: Jian-Hua Cheng; Ding Nie; Bin Li; Song-Bai Gui; Chu-Zhong Li; Ya-Zhuo Zhang; Luigi Maria Cavallo; Peng Zhao Journal: Mil Med Res Date: 2021-07-02